A5101711966- Fungal and yeast genetics research
- Cancer-related molecular mechanisms research
- Microbial Metabolic Engineering and Bioproduction
- MicroRNA in disease regulation
- Biofuel production and bioconversion
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Genomics and Chromatin Dynamics
- Gut microbiota and health
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Aquaculture disease management and microbiota
- Cardiac Ischemia and Reperfusion
- Yersinia bacterium, plague, ectoparasites research
- Cancer Mechanisms and Therapy
- Plant Gene Expression Analysis
- Myofascial pain diagnosis and treatment
- Pain Management and Placebo Effect
- Bacillus and Francisella bacterial research
- Liver Disease Diagnosis and Treatment
Shanghai Jiao Tong University
2021-2025
Academy of Military Medical Sciences
2023-2024
First People's Hospital of Yunnan Province
2017-2023
Dongguan People’s Hospital
2023
Guangdong Medical College
2023
Kunming University of Science and Technology
2020-2023
State Key Laboratory of Microbial Metabolism
2021
Wuhan Sixth Hospital
2019
Shandong Provincial Hospital
2016
Shandong University
2016
Lung cancer is the first leading cause of cancer-related deaths both worldwide and in China threatens human health quality life. New drugs therapeutic methods are urgently needed. Our study evaluated roles dihydroartemisinin (DHA) lung further explored its underlying mechanisms.CCK-8, colony formation trypan blue exclusion assays were used to detect cell viability, ability death. qRT-PCR Western blotting applied analyze expressions key molecules.DHA inhibited proliferation abilities enhanced...
Enhanced environmental stress tolerance is important for microbial production of biofuels and biobased chemicals. However, the roles chromatin regulation in bioproduction remain unclear. Here, we explore effects Ino80, core subunit INO80 remodeling complex, on yeast adaptation. We found that deletion led to increased sensitivity budding Saccharomyces cerevisiae acetic acid, which a common inhibitor lignocellulosic biomass also serves as food preservative. Integrated ATAC-seq RNA-seq analyses...
Seagull as a migratory wild bird has become most popular species in southwest China since 1980s. Previously, we analyzed the gut microbiota and intestinal pathogenic bacteria configuration for this by using 16S rRNA sequencing culture methods. To continue in-depth research on microbiome of seagulls, metagenomics, DNA virome RNA were both investigated their microbial communities abundance diversity study.The metagenomics results showed 99.72% total was bacteria, followed viruses, fungi,...
The Greatwall-family protein kinase Rim15 is associated with the nutrient starvation response, whereas its role in oxidative stress responses remains unclear. Here, acetic acid and peroxide were used as two elicitors. antioxidant indicator assay under revealed impaired growth rim15Δ related to regulation of systems. Comparative transcriptome analysis that differentially expressed genes (DEGs) are predicted be mostly regulated by stress-responsive transcriptional factor Yap1. Among DEGs,...
Intestinal ischemia and reperfusion (II/R) injury often triggers severe in remote organs, with the lungs being considered main target. Excessive elevation of proinflammatory cytokines is a major contributor occurrence development II/R‑induced acute lung (ALI). Therefore, present study aimed to investigate whether blocking tumor necrosis factor‑α (TNF‑α) expression could protect from following II/R, explore possible underlying mechanism involving interleukin‑10 (IL‑10). Briefly, II/R was...
Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (II/R) and contributes to the associated high mortality rate. However, underlying mechanism poorly understood treatments are limited. RNA interference (RNAi) has been demonstrated provide promising disease treatment strategy both in vitro vivo. Therefore, present study aimed test whether blocking proinflammatory cytokine IL‑6 by RNAi may protect lungs from remote organ II/R, investigate potential...
Recently, several miRNAs have been revealed to play critical roles in oncogenesis and tumor progression of many cancers. Thioredoxin-1 (Trx-1) binding protein-2 (TBP-2) is an internal inhibitor Trx-1, which plays the role regulating oxidative stress, inhibiting cell growth, promoting apoptosis. The expression TBP-2 usually decreased cancer tissues. However, whether regulate lung still unclear. In this study, we examined levels TBP-2, miR-93, miR-373, miR-17-5p tissues their adjacent normal...
Background: Fascial pathological pain is the main type of chronic in older adults today, and studying relationship between fascia can help clinical search for effective treatments. However, face vast amount research findings, there no systematic assessment a bibliometric analysis. Therefore, purpose this study to analyze studies on using CiteSpace VOSviewer identify hotspots future directions. Materials Methods: A total 744 papers related from 2013 2022 were collected core collection...
Cerebral ischemia (CI) is a severe brain injury resulting in variety of motor impairments combined with secondary remote organs, especially the lung. This condition occurs due to insufficient blood supply during infancy. However, it has molecular linkage that needs be thoroughly covered. Here, we report on role vascular endothelial growth factor C (VEGFC) lung induced by CI. The middle cerebral artery occlusion (MCAO) was depended establish animal model Rats were used and confirmed through...
To explore the formation of pre-metastatic niche in mouse lung and to study underlying molecular mechanisms whereby primary breast carcinoma-derived factors mediate recruitment bone marrow-derived cells (BMDCs) affect environment before arrival tumor cells.Mammary carcinoma 4T1 were inoculated into mammary gland construct model cancer. Confocal microscopy was used detect BMDCs lungs. The expression sera cell culture media assayed using RayBio Custom cytokine antibody array kit. mice injected...
We aimed to develop an efficient detection platform that can identify a larger number of suspicious samples in single test, saving time, manpower, and material costs, providing vital support the public health system coping with current challenging dynamic bioterrorism threat landscape, particularly regions turmoil conflict. have successfully developed high-throughput, multitarget fluorescent array by effectively combining integrating multiprobe amplification (MPA) melting curve analysis....
Background Shotgun metagenomic and 16S rDNA sequencing are commonly used methods to identify the taxonomic composition of microbial communities. Previously, we analysed gut microbiota intestinal pathogenic bacteria configuration migratory seagulls by using culture methods. Methods To continue in-depth research on microbiome reveal applicability two methods, compared metagenome amplicon results further demonstrate features this animal. Results The number bacterial species detected...
Acetic acid is a common inhibitor present in lignocellulosic hydrolysate. Development of acetic tolerant strains may improve the production biofuels and bio-based chemicals using biomass as raw materials. Current studies on stress tolerance yeast Saccharomyces cerevisiae have mainly focused transcription control, but role transfer RNA (tRNA) was rarely investigated. We found that some tRNA genes showed elevated levels strain. In this study, we further investigated effects overexpressing an...