A5007642052- Pharmacovigilance and Adverse Drug Reactions
- Myofascial pain diagnosis and treatment
- Computational Drug Discovery Methods
- Data Visualization and Analytics
- Inflammatory mediators and NSAID effects
- Acupuncture Treatment Research Studies
- Alzheimer's disease research and treatments
- Interactive and Immersive Displays
- Cholinesterase and Neurodegenerative Diseases
- Pharmaceutical Economics and Policy
- Cellular Mechanics and Interactions
- Laser Applications in Dentistry and Medicine
- Geographic Information Systems Studies
- Additive Manufacturing and 3D Printing Technologies
- Hemodynamic Monitoring and Therapy
- Chronic Lymphocytic Leukemia Research
- Silk-based biomaterials and applications
- Biopolymer Synthesis and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neuroscience, Education and Cognitive Function
- Shoulder Injury and Treatment
- Infrastructure Resilience and Vulnerability Analysis
- Acute Kidney Injury Research
- Peripheral Nerve Disorders
- Proteoglycans and glycosaminoglycans research
Third Affiliated Hospital of Southern Medical University
2023-2025
Southern Medical University
2015-2025
Dongguan People’s Hospital
2018-2025
Center for Translational Molecular Medicine
2025
Chinese Academy of Sciences
2003-2022
Xinjiang Institute of Ecology and Geography
2022
Czech Academy of Sciences, Institute of Psychology
2021
Shanxi Academy of Medical Sciences
2020-2021
Computer Network Information Center
2017
Institute of Software
2013
Background Metformin has the potential for treating numerous diseases, but there are still many unrecognized and unreported adverse events (AEs).
Male infertility, age-related changes, and tumors have been increasingly studied in the field of male reproductive health due to emergence environmental stressors, declining fertility rates, aging populations. Numerous studies demonstrated that ERK1/2 signaling pathway plays a significant role reproduction. The is associated with several pathways has complex interplay influences spermatogenic microenvironment, sperm viability, gonadal axis regulation, as well resistance testicular tumors....
Background Despite its widespread use, the adverse effects (AEs) of memantine have not been well documented, and there is a need to find new ways analyze AEs memantine.
The recent adverse reactions associated with semaglutide have led the Food and Drug Administration (FDA) to issue a "black box warning", it is necessary analyze all reports of improve safety its clinical use.
Inflammation and cartilage degeneration are critical challenges in osteoarthritis (OA) treatment. Achieving sustained drug efficacy while mitigating the adverse effects of inflammation reactive oxygen species remains a significant challenge. This study synthesizes gallic acid-magnesium (GA-Mg) metal–organic framework (MOF) as carrier for puerarin (PA). The PA-loaded GA-Mg MOF (pGM) is encapsulated within chondroitin sulfate methacrylate, forming monodisperse hybrid microspheres (CM@pGM)...
Background Celecoxib is now clinically recognized as a candidate for treating various neurological disorders and cancers. The recent emergence of some serious adverse reactions concerning.
Abstract As the cornerstone of medicine, development anatomy is related to many disciplines and fields has received extensive attention from researchers. How integrate grasp cutting‐edge information in this field quickly a challenge for researchers, so aim study analyze research using CiteSpace VOSviewer order identify hotspots future directions. To offer fresh viewpoint assessing academic influences nations, or institutions on anatomy, examine anatomical forecast trends. A total 4637...
Based on the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database, we analyzed signals of potential adverse events (AEs) orlistat in real world to provide a reference for its safe clinical use.
Ibuprofen is commonly used as an over-the-counter (OTC) antipyretic and analgesic. As the frequency of its use has increased, there been a corresponding increase in reports associated adverse events (AEs). However, these have not systematically reported literature. Meanwhile, importance effective pharmacovigilance evaluating benefits risks drugs being recognized. The data was obtained indirectly from FAERS using OpenVigil 2 database, lexically mapped software such MySQL, Microsoft Excel, R...
Abstract Many governments have established public‐private partnerships to manage critical infrastructure protection, one element of which is telecommunications. However, in New Zealand these collaborative efforts had limited success and the rapid increase use Internet support both society commerce has led need for a more specific focus this area. While regulation an effective means forcing action by industry, it can lead significant unintended consequences undesirable behaviours. This...
Alzheimer's disease (AD) is the most common neurodegenerative disease, severely reducing cognitive level and life quality of patients. Byu dMar 25 (BM25) has been proved to have a therapeutic effect on AD. However, pharmacological mechanism still unclear. Therefore, this study aims reveal potential BM25 affecting AD from perspective network pharmacology experimental validation.The active ingredients were obtained TCMSP database literature. Possible targets predicted using...
Background: Banxia Xiexin decoration (BXD), a complex prescription in Traditional Chinese Medicine (TCM), clinically acts as treatment for gastritis and diabetes while its mechanism of remains unknown. Objection: This study aimed to explore the common BXD treating based on network pharmacology molecular docking technology. Methods: The seven herbal components drug targets were collected from Systems Pharmacology Database Analysis Platform (TCMSP) using GeneCards, DisGeNET, Comparative...
In recent years, β-blockers such as metoprolol have been upgraded to first-line antihypertensive drugs. However, demonstrates poor prognosis effects on diseases stroke. Further clinical application may expand the possibility of its related adverse reactions. Currently, there is a lack comprehensive research overall safety metoprolol.
Background: Fascial pathological pain is the main type of chronic in older adults today, and studying relationship between fascia can help clinical search for effective treatments. However, face vast amount research findings, there no systematic assessment a bibliometric analysis. Therefore, purpose this study to analyze studies on using CiteSpace VOSviewer identify hotspots future directions. Materials Methods: A total 744 papers related from 2013 2022 were collected core collection...
Objective. To explore the related mechanism of acupuncture affecting obesity by regulating inflammation using bioinformatics methods. Methods. The genes to obesity, inflammation, and were mined GenCLiP 3, intersecting extracted Venn diagram. DAVID database was employed for pathway enrichment analysis functional annotation coexpressed genes. Then, protein-protein interaction (PPI) network constructed with STRING visualized Cytoscape software screened out important hub Finally, Boxplot...
Sketching user interface and virtual reality (VR) techniques to education application has become popular, promising make the teaching learning experience more natural efficient for users. The adaptive support can improve intelligence during interaction process between systems emphasize individual needs. In this paper, we present sketching geometry VR class integrated with corresponding adaptation support, which meet requirements application. Furthermore, analyze sketch context mechanism in...
Abstract Docking simulation of 18 agonists with the ligand binding pocket (LBP) PPARγ has been performed. The conformations and affinities these were obtained by use flexible docking protocol FlexX. Test compound calculations indicated that FlexX can reproduce conformation crystal structure (root mean square deviation = 1.43 Å); moreover, predicted correlate well activities agonists. interaction model pharmacophore derived difference in biologic be explained. must have both polar head...
Information on anatomy of the Cun position at wrist is lacking; whether blood vessel taking pulse in radial artery or superficial palmar branch also clinically controversial. The objective was to investigate boundaries and contents, vascular distribution their points Cun. Thirty-two upper extremities 16 human cadavers were investigated for dissection observation. boundaries, observed; location identified; length (L1), pulp width index finger (L2), angle between measured. results showed that...
BACKGROUND:We sought to create a model that incorporated ultrasound examinations predict the risk of acute kidney injury (AKI) after percutaneous coronary intervention (PCI) or cardiopulmonary bypass (CPB) surgery. MATERIAL AND METHODS:A total 292 patients with AKI PCI CPB surgery were enrolled for study. Afterwards, treatment-related information, including data pertaining examination, was collected. A random forest and multivariate logistic regression analysis then used establish predictive...
Biofabrication, broadly described as “a process that results in a defined product with biological function,” has undergone revolution recent years. This led to an explosion of literature containing valuable data and insights on bioactive materials machine learning-aided design. However, the accessibility comprehension this rich source remain challenge, necessitating creation comprehensive database. Herein, we present manufacturing multi-organs database (MMDB), real-time...
Background: Danxiong Huoxue tablets have been used clinically to prevent and treat Heterotopic Ossification (HO) after total hip arthroplasty, but its therapeutic mechanism is not clear. background: Tablets has heterotopic ossification Objectives: This study investigated the potential of action against HO using network pharmacology molecular docking methods. Methods: The TCMID SymMap databases existing literature were screen active ingredients targets tablets, obtained from Gene Cards,...