A5103009981- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- NF-κB Signaling Pathways
- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Prostate Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Perfectionism, Procrastination, Anxiety Studies
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
Shanghai Sixth People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Harbin Medical University
2024
North China University of Science and Technology
2023
Shanxi Academy of Medical Sciences
2021-2022
Sun Yat-sen University
2019-2021
Sun Yat-sen University Cancer Center
2019-2021
State Key Laboratory of Oncology in South China
2021
Peking University First Hospital
2020
Peking University
2020
Background Tumor-infiltrating lymphocytes have been reported as prognostic markers in tumors. We aimed to assess the value of total T cell (CD3 + ) density, cytotoxic (CD8 density and memory (CD45RO patients with nasopharyngeal carcinoma (NPC). Methods The expression CD3, CD8 CD45RO was detected by immunohistochemistry training (n=221) validation cohorts (n=115). densities these three were quantified digital pathology both tumor stroma. Then, we developed immune score based on further...
Abstract Background The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence a leading clinical bottleneck in NPC. Revealing the mechanism of NPC will help improve therapeutic effect. Methods In this study, role TRIM21 (tripartite motif–containing 21) receiving ionizing radiation was firstly examined both vivo and vitro. Mass spectrometry analysis performed to identify downstream targets TRIM21. cells with or SERPINB5 (serpin...
Medical students face a heavy burden as they are tasked with acquiring vast amount of medical knowledge within limited time frame. Self-directed learning (SDL) has become crucial for efficient and ongoing among students. However, effective ways to foster SDL ability Chinese lacking, studies have identified factors that impact the This makes it challenging educators develop targeted strategies improve students' ability. study aims assess examine effects career calling teaching competencies on...
Background and objective: The prognostic value of circulating lymphocyte subsets in cervical cancer patients receiving postoperative radiotherapy remains unclear. This study aimed to explore the significance these this patient population. Methods: Peripheral blood samples were collected from 101 prior radiotherapy. Flow cytometry was utilized determine proportions absolute counts subsets, including total T cells, CD4+ CD8+ natural killer (NK) B cells. Kaplan-Meier method Cox regression...
This study aimed to evaluate the correlation between pre-treatment peripheral platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI) with efficacy prognosis of radiotherapy for cervical cancer. A total 110 patients cancer who received at our hospital from November 2017 2020 were retrospectively analysed. The cut-off values PLR PNI obtained using receive operating characteristic curve (ROC) Youden index. divided into high low groups. We compared clinical characteristics,...
Rationale: Currently, for locoregionally advanced nasopharyngeal carcinoma (LA-NPC), there is no effective blood-based method to predict distant metastasis. We aimed detect plasma protein profiles identify biomarkers that could distinguish patients with NPC who are at high risk of posttreatment Methods: A high-throughput antibody array was initially applied 1000 proteins in pretreatment from 16 matched LA-NPC or without metastasis after radical treatment. Differentially expressed were...
Eps15 homology domain-containing 2 (EHD2) is a tumor suppressor gene, overexpressed in several solid tumors, including ovarian cancer and esophageal squamous cell carcinoma. The current study examined the expression role of EHD2 human breast cancer. was determined by Western blot immunohistochemistry (IHC) 80 paired noncancerous tissues. Correlations between clinicopathologic variables, overall survival, were analyzed. We investigated migration invasion wound healing assay trans-well assays....
The chaperonin-containing T‑complex protein 1 (CCT) has eight subunits, CCT 1-8, which are dysregulated in several types of cancer. To determine how subunit 8 (CCT8) influences the development esophageal squamous cell carcinoma (ESCC), immunohistochemistry and western blot analysis were performed on 128 ESCC samples present study to measure expression CCT8. prognostic value CCT8 was analyzed using univariate multivariate survival analyses. knockdown cells subsequently, migration invasion...
To analyze the pattern of local failure in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT) and find a more reasonable delineation clinical target volume (CTV).A total 212 non-metastatic NPC who underwent IMRT were analyzed. Radiation therapy was run at dose 66-74 Gy (2.0-2.2 fractions). The follow-up recurrence recurrence-related features analyzed for original treatment situation. failures delimited as "in-field failure" if Vrecur within 95% isodose...
Abstract Objective The objective of this research was to analyze the prognostic significance minimum count lymphocytes (LY) and corresponding ratio neutrophil‐to‐lymphocyte (NLR) in cervical cancer (CC) patients receiving radiotherapy. Methods We retrospectively collected data from 202 CC who received concurrent chemoradiotherapy or radiotherapy alone at our hospital. Statistical methods including Kaplan–Meier method, log‐rank test Cox proportional hazards model were included examine...
We evaluated the non-inferiority of nedaplatin-based and cisplatin-based concurrent chemoradiotherapy in cervical cancer patients.Patients aged 28-82 years with pathologically diagnosed (stage IB-IVA) were randomly chosen for study. Patients both cisplatin nedaplatin groups received radiotherapy weekly intravenous 30 mg/m2 or 40 concurrently.One hundred sixty patients who treatment between 10 May 2018 31 August 2020 included. The 3-year overall survival group (median 30.5 months) was not...
The human EGFR2 (HER2) signaling pathway is one of the most actively studied targets in cancer transformation research. Ttriplex-forming oligonucleotides (TFOs) activate DNA damage and induce apoptosis. We aim to encapsulate TFO-HER2 with nano-particle ZW-128 suppress breast cell growth vitro vivo.We designed a set TFO fragments targeting HER2 verified their effectiveness. encapsulated form nano-drug TFO@ZW-128. Cell counting kit 8, flow cytometry, western blotting were used evaluate effect...
Receptor tyrosine kinases (RTKs) expression and the growth factor such as platelet-derived (PDGF) their receptors have been considered relevant in process of angiogenesis dissemination esophageal squamous cell carcinoma (ESCC). Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) downstream RTK signaling was a critical regulator PDGF (PDGFR) stability. The aim present study to examine SGTA elucidate its clinicopathologic significance ESCC. Immunohistochemistry...
Background . Keloids are hard nodules or plaques formed by excessive proliferation of connective tissue. Radiotherapy, widely used in various benign and malignant skin diseases, is an effective treatment for keloids. This work evaluates Intrabeam photon radiotherapy the management Methods. Fourteen patients who have undergone a total 15 sites keloids were followed up. Twelve cases first onset other two had recurrent diseases. Thirteen underwent surgical resection before radiotherapy. One...