A5000132814- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Ferroelectric and Piezoelectric Materials
- Magnesium Alloys: Properties and Applications
- Nanoparticle-Based Drug Delivery
- Electronic and Structural Properties of Oxides
- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Semiconductor materials and devices
- Additive Manufacturing and 3D Printing Technologies
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Dental materials and restorations
- Biosensors and Analytical Detection
- Electrospun Nanofibers in Biomedical Applications
- Electrochemical sensors and biosensors
- Metal and Thin Film Mechanics
- Microwave Dielectric Ceramics Synthesis
- Welding Techniques and Residual Stresses
- Advanced Proteomics Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Glycosylation and Glycoproteins Research
- Dental Erosion and Treatment
- SARS-CoV-2 detection and testing
- Orthopaedic implants and arthroplasty
The University of Queensland
2015-2024
Jilin University
2007-2024
The University of Sydney
2024
Zhengzhou University
2017-2022
Central South University
2021-2022
North University of China
2022
Brisbane School of Theology
2015-2020
Zhengzhou University of Industrial Technology
2019
Wuhan University
2012-2017
National University of Singapore
2011-2016
A new type of monodispersed mesoporous silica nanoparticles with a core–cone structure (MSN‐CC) has been synthesized. The large cone‐shaped pores are formed by lamellae closely packed encircling spherical core, showing similar to the flower dahlia . MSN‐CC pore size 45 nm and high volume 2.59 cm 3 g −1 demonstrates loading capacity proteins successfully delivers active β‐galactosidase into cells, their potential as efficient nanocarriers for cellular delivery molecular weights.
Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death activating cells. A simple physical mixture of chemodrugs in combination with blockades show synergistically concurrently enhanced chemo-immunotherapy efficacy, inhibiting growth both treated...
Abstract Hypoxia‐activated prodrugs have brought new opportunities for safe and effective tumor ablation, but their therapeutic efficacy is limited by insufficient activation in microenvironments. Herein, a novel cascade delivery system with tandem functions integrating hypoxia‐activated prodrug (AQ4N) glucose oxidase (GOx) designed to improve its efficacy. Innovative yolk–shell organosilica nanoparticles tetrasulfide bridged composition, small‐pore yolk, large‐pore shell featuring...
Abstract The direct depletion of lactate accumulated in the tumor microenvironment holds promise for cancer therapy but remains challenging. Herein, we report a one‐pot synthesis openwork@ dendritic mesoporous silica nanoparticles (ODMSNs) to address this problem. ODMSNs self‐assembled through time‐resolved lamellar growth mechanism feature an openworked core and shell, both constructed by nanosheets ≈3 nm. With large pore size, high surface area volume, exhibited loading capacity (>0.7 g...
Osteoarthritis (OA) is a common joint degenerative disease that causes pain, damage, and dysfunction. External hyaluronic acid (HA) supplement method for the management of osteoarthritis which requires multi-injections. It demonstrated biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from temporomandibular (TMJ) generate endogenous HA with high molecular weights. In rat TMJ inflammation model, this strategy...
Deoxyribonuclease I (DNase I) was loaded and delivered by silver-doped mesoporous silica nanoparticles (MSN-Ag) for biofilm treatments.
Bioactive membranes with growth factors that mimic the physiological microenvironment of periodontal tissues have shown great potential for guided tissue regeneration (GTR). However, loss bioactivity and uncontrolled drug release in conventional limit their efficacy. In addition, local infection control ability would provide additional benefits to regeneration. this work, nanoengineered factor antibiotic delivery capabilities were developed achieve dual functions efficient GTR. Mesoporous...
Lateral flow immunoassays (LFIAs) have drawn much attention in point-of-care diagnostic applications, and the development of high-performance label materials is key. In this study, impact surface chemistry dendritic mesoporous silica nanoparticles (DMSNs) on their enrichment performance toward quantum dots (QDs) signal amplification resultant DMSNs-QDs as been investigated. A series DMSNs with controllable amino/thiol group densities synthesized. It demonstrated that amino groups are...
Abstract Using dendritic mesoporous silica nanoparticles (DMSNs) for quantum dots (QDs) enrichment and signal amplification is an emerging strategy improving the detection sensitivity of lateral flow immunoassay (LFIA). In this study, a new convenient approach developed to prepare water‐dispersible DMSNs‐QDs. A series DMSNs with various diameters (138, 251, 368, 471 nm) are studied loading QDs LFIA applications. The resultant DMSNs‐QDs exhibit high fluorescence retention 81.8%. increase in...
Thiolated dendritic mesoporous silica nanoparticles (T-DMSNs) with ultrahigh density of thiol groups (284.6 ± 9 μmol g-1) are synthesized and used to load gold tunable sizes (1.2-2.7 nm) high content (34.0 wt %). It is demonstrated that the size has a significant impact on their peroxidase-mimicking activity. At an optimized 1.9 nm, T-DMSNs@Au exhibits highest Our contribution provides new insights into rational design nanozymes for future applications.
Abstract Recently, dendritic mesoporous silica nanoparticles with widespread applications have attracted great interest. Despite many publications (>800), the terminology “dendritic” is ambiguous. Understanding what possible “dendritic structures” are, their formation mechanisms and underlying structure–property relationship fundamentally important. With advance of characterization techniques such as electron tomography, two types tree‐branch‐like flower‐like structures can be...
Insulin administration mimicking physiological insulin secretion behavior remains a challenge for the treatment of patients with type I diabetes. Herein, we report novel glucose-responsive insulin-release nanosystem through an enzyme–polymer layer-by-layer coating strategy on silica vesicles loaded insulin. With choice polyethylenimine prioritized proton binding capability and glucose specific enzymes in layer, threshold can be adjusted desired concentration range 5–20 mM first time. In...
Magnesium has been suggested as a potential biodegradable metal for the usage orthopaedic implants. However, high degradation rate in physiological environment remains biggest challenge, impeding wide clinical application of magnesium‐based biomaterials. In order to reduce its and improve biocompatibility, micro‐arc oxidation coating doped with HA particles (MAO‐HA) was applied inner coating, polydopamine (PDA) film synthesized by dopamine self‐polymerization outer coating. The...
Magnesium (Mg), a potential biodegradable material, has drawn wide attention in the bone reconstruction field. However, Mg alloys, served as graft substitution, remain clinical challenge, antibacterial activity of which is required to be enhanced. Here, we prepared magnesium Mg-Zn-Y-Nd-Ag and then had it been further densified by extruding. The microstructure evolution as-cast as-extruded Mg- Zn-Y-Nd-Ag was characterized using optical microscope X-ray diffraction analyses (XRD). results...
The poor corrosion resistance of biodegradable magnesium alloys is the dominant factor that limits their clinical application. In this study, to deal with challenge, fluoride coating was prepared on Mg-Zn-Ca alloy as inner and then hydroxyapatite (HA) outer deposited by pulse reverse current electrodeposition (PRC-HA/MgF2). As a comparative microstructure properties composite fabricated traditional constant (TED-HA/MgF2) were also investigated. Scanning electron microscopy (SEM) images...
An ultrasensitive enzyme-linked immunosorbent assay (ELISA+) has been developed by using dendritic mesoporous silica nanoparticles (DMSNs) with high horseradish peroxidase (HRP) loading and easily accessible pore channels for signal amplification. A 2000 times enhancement of detection sensitivity compared to a commercial ELISA kit insulin in serum is achieved.