The present work describes the development of poly(lactic co-glycolic acid) (PLGA) nanoparticles (NPs) rutin (RT) for treatment hepatocellular carcinoma in rats.RT-loaded PLGA NPs (RT-PLGA-NPs) were prepared by double emulsion evaporation method. Further these are optimized Box-Behnken design. evaluated size, polydispersity index, drug-loading capacity, entrapment, gastric stability, vitro drug release, vivo preclinical studies and biochemical studies.Preclinical evaluation RT-PLGA-NPs...

Astaxanthin nanoformulation was found appropriate in all measures with strong antioxidant activity against H₂O₂induced oxidative stress PC12 cells. Biodistribution and brain delivery also to be superior conventional dosage form.

The present study describes the synthesis of novel bigels as delivery matrices for controlled applications. were prepared by mixing agar hydrogel and stearyl alcohol oleogel in different proportions. microscopic analysis suggested formation biphasic at lower proportions bicontinuous bigel higher Stress relaxation was used to analyze mechanical properties. viscoelastic property estimated modeling profile using Weichert model viscoelasticity. electrical showed an increase impedance values...

Direct, reliable, controlled, and sustained drug delivery to female reproductive tract (FRT) remains elusive, with conventional dosage forms falling way short of the mark, leading premature leakage, erratic delivery, loss compliance. Historically, intravaginal route underserved by pharmaceutical sector. To comprehensively address this, we turned our focus phase-transforming sol-gels, using poloxamers, a thermosensitive polymer and, doxycycline (as hyclate salt, DOXH) as model agent given its...

Due to their affordability and environmental friendliness, green technology approaches are increasingly exploited synthesize AgNPs. The manufacture of AgNP using biological methods, such as plants, fungi, bacteria catalysts, is covered in several research studies. Using AgNPs the most appealing, straightforward, environmentally friendly, economical source. As a result, more reports being produced various bacterial genera species (both Gram-positive negative). variety Gram-negative) that can...

Intranasal delivery is the most preferred route of drug administration for treatment a range nasal conditions including chronic rhinosinusitis (CRS), caused by an infection and inflammation mucosa. However, localised lipophilic drugs persistent challenge especially with traditional topical sprays. In this study, composite thermoresponsive hydrogel developed tuned to obtain desired rheological physiochemical properties suitable intranasal drugs. The comprised drug-loaded porous silicon (pSi)...

Abstract A range of liquid emollient ester‐loaded body emulsions were evaluated on the basis sensory profile, consumer perception, physicochemical, biometrological, and rheological performances. This was complemented by skin hydration transepidermal water loss (TEWL) studies performed using a Corneometer® Tewameter®, respectively. The showed similar behavior creams variation shear stress, frequency, temperature. However, performances found varied when compared between base cream...

Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia. However, it causes many adverse drug reactions (ADRs), which lead to poor treatment outcomes. Nose-to-brain (N2B) delivery offers a promising approach reduce peripheral ADRs by minimizing systemic exposure. The aim of present study was develop and characterize clozapine-loaded nanoemulsion sol–gel (CLZ-NESG) intranasal administration using high energy sonication method. A range oils, surfactants,...

(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive sol-gels for N2B delivery. (2) Methods: Poloxamer 407 and hydroxypropyl methylcellulose were mixed hydrated water. Glycerin carbopol solutions added mixture stirred overnight at 2-8 °C. 0.1% w/w was polysorbate 20 (PS20) or 80 (PS80) RT (25 °C)...

Prunus amygdalus Batsch (almond) is a classical nutritive traditional Indian medicine. Along with anti-oxidant properties, it is, clinically, used in the treatment of various diseases underlying mechanism. This study an effort to scrutinise renal protective effect P. or green almond (GA) seed coat extract and its mechanism animal model Ferric nitrilotriacetate (Fe-NTA) induced cell carcinoma (RCC). RCC was Swiss Albino Wistar rats by intraperitoneal injection Fe-NTA. The were then treated...

The current study discusses the synthesis of novel gelatin–chitosan lactate cohydrogels. Mechanical studies indicated viscoelastic nature cohydrogels were predominantly elastic in nature. Inherent mechanical stability was better than pristine gelatin hydrogel. Incorporation chitosan improved vitro swelling and drug release properties showed good antimicrobial delivery capacity. developed demonstrated that they could be used as vehicles for drugs. Cell proliferation suggested supported human...

To demonstrate safety of a developed intranasal dexamethasone-infused in situ gelling formulation, quantification validated clinical biomarker indicative cytotoxic potential using human sinonasal explant model was first confirmed. Systematic cytotoxicity studies the lactate dehydrogenase (LDH) detection assay revealed no elevation from baseline, LDH levels, with tissue integrity explanted nasal mucosa also maintained; this further corroborated histopathological examination. Next, confirmed...

The present study reports the in-depth analysis of gelatin–carboxymethyl chitosan hydrogels. composite system formed phase-separated hydrogels, which is confirmed by scanning electron microscopy. swelling carboxymethyl chitosan-containing hydrogels was lower than gelatin hydrogel. Macroscale deformation using a static mechanical tester indicated viscoelastic nature A decrease in impedance observed with an increase content. drug release from predominantly Fickian diffusion mediated and...

Etodolac, a nonsteroidal antiinflammatory drug, widely used in arthritis is associated with gastric ulceration and irritation due to presence of free carboxylic group. The current investigation reports synthesis mutual amide prodrug etodolac by masking group glucosamine, nutritional supplement for treatment arthritis. Confirmation characterization the structure synthesized done elemental spectroscopy analysis, melting point, determination migration parameters (Rf, RM, Rt) using thin layer...

Agar–gelatin-based co-hydrogels were prepared with different compositions of the agar and gelatin fractions. The intermolecular hydrogen bonding was higher in as compared to hydrogel. Swelling studies indicated diffusion-mediated swelling. electrical stability Though firmness higher, Weichert model viscoelasticity that inherent mechanical hydrogel superior. release ciprofloxacin hydrochloride predominately Fickian diffusion-mediated. In gist, can be tried polymeric constructs for controlled...

<h3>Background and aims</h3> Rheumatoid arthritis (RA) is an autoimmune disease, which induces systematic typical inflammation affects 1% younger population Worldwide. Natural products are being preferred over the available treatment regimes for arthritis. <i>Moringa oleifera</i> has been very popular ethanomedicine of inflammatory disorders in North-eastern part India. With this background, current investigation was carried out to scrutinise anti-arthritic potential complete fruend's...