A5062027562- Date Palm Research Studies
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Genetic and Environmental Crop Studies
- Bacterial biofilms and quorum sensing
- Enzyme-mediated dye degradation
- Advanced biosensing and bioanalysis techniques
- Biochemical and Structural Characterization
- Phytochemicals and Antioxidant Activities
- Electrochemical sensors and biosensors
- Epigenetics and DNA Methylation
- Microbial Metabolism and Applications
- Antimicrobial Peptides and Activities
- Inflammatory mediators and NSAID effects
- Catalysis and Hydrodesulfurization Studies
- Electrochemical Analysis and Applications
- Drug-Induced Hepatotoxicity and Protection
- Clostridium difficile and Clostridium perfringens research
- Computational Drug Discovery Methods
- Biofuel production and bioconversion
- Diet and metabolism studies
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Protein Hydrolysis and Bioactive Peptides
- Pharmaceutical and Antibiotic Environmental Impacts
King Abdulaziz University
2017-2024
University of Jeddah
2017-2023
King University
2023
King Abdul Aziz University Hospital
2016
University of Sheffield
2013
Abstract The aim of the present study was to investigate alterations in gut microbiota associated with hypercholesterolemia and treatment atorvastatin, a commonly prescribed cholesterol-lowering drug. In this study, seven experimental groups rats were developed based on diets [high-fat diet (HFD) normal chow (NCD)] various doses atorvastatin HFD NCD groups. 16S rRNA amplicon sequencing used analyze microbiota. Atorvastatin significantly reduced cholesterol level treated rats. Bacterial...
The present work describes the development of poly(lactic co-glycolic acid) (PLGA) nanoparticles (NPs) rutin (RT) for treatment hepatocellular carcinoma in rats.RT-loaded PLGA NPs (RT-PLGA-NPs) were prepared by double emulsion evaporation method. Further these are optimized Box-Behnken design. evaluated size, polydispersity index, drug-loading capacity, entrapment, gastric stability, vitro drug release, vivo preclinical studies and biochemical studies.Preclinical evaluation RT-PLGA-NPs...
Hypercholesterolemia is one of the most important risk factors for development cardiovascular diseases. The composition gut microbiota (total microbes residing in gut) impacts on cholesterol and lipid metabolism. On contrary, alterations response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing evaluate bacterial community 15 untreated hypercholesterolemic patients (HP) 27...
An assortment of environmental matrices includes arsenic (As) in its different oxidation states, which is often linked to concerns that pose a threat public health worldwide. The current difficulty lies addressing toxicological and achieving sustained detoxification As. Multiple conventional degradation methods are accessible; however, they indeed labor-intensive, expensive, reliant on prolonged laboratory evaluations. Molecular interaction atomic level mechanisms for enzyme-As exploration...
Hypervirulent K. pneumoniae (hvKP) strains possess distinct characteristics such as hypermucoviscosity, unique serotypes, and virulence factors associated with high pathogenicity. To better understand the genomic profile of isolated hvKP strain, data were compared to genomes hypervirulent typical strains. The strain was from a patient recurrent urinary tract infection, then string test used for detection hypermucoviscosity phenotype. Whole-genome sequencing conducted using Illumina,...
Abstract The purpose of this study is to evaluate the likely defensive impact Ajwa date aqueous extract (AJDAE) in alleviating nephrotoxicity generated by doxorubicin (DOX) injection rats. Sixty male Wister albino rats were randomly and equally separated into six groups ( n = 10), they treated as follows: untreated control group, administered with 0.75 1.5 mg kg bw AJDAE, toxicant group DOX, prophylactic mg/kg AJDAE 15 DOX. Biochemical parameters, antioxidant enzymes, renal functions, DNA...
The epigenetic silencing of tumor suppressor genes (TSGs) is a common finding in several solid and hematological tumors involving various readers writers leading to enhanced cell proliferation defective apoptosis. Thymoquinone (TQ), the major biologically active compound black seed oil, has demonstrated anticancer activities by targeting pathways. However, its effects on code cancer cells are largely unknown. In present study, we performed RNA sequencing investigate mechanisms TQ-treated...
The presence of antimicrobial-resistance genes (ARGs) in mobile genetic elements (MGEs) facilitates the rapid development and dissemination multidrug-resistant bacteria, which represents a serious problem for human health. This is One Health study aims to investigate co-occurrence antimicrobial resistance determinants among clinical environmental isolates K. pneumoniae E. coli. Various bioinformatics tools were used elucidate bacterial strains’ ID, resistome, virulome, MGEs, phylogeny 42...
Abstract Drug repurposing is an emerging field in drug development that has provided many successful drugs. In the current study, paracetamol, a known antipyretic and analgesic agent, was chemically modified to generate paracetamol derivatives as anticancer anticyclooxygenase‐2 (COX‐2) agents. Compound 11 bearing fluoro group best cytotoxic candidate with half‐maximal inhibitory concentration (IC 50 ) values ranging from 1.51 6.31 μM anti‐COX‐2 activity IC = 0.29 μM, compared standard drugs,...
Background and aims: Cancer continues to be a significant source of both illness death on global scale, traditional medicinal plants continue serve as fundamental resource natural bioactive compounds an alternative remedies. Although there have been numerous studies the therapeutic role Phoenix dactylifera , study peptides has not thoroughly investigated. This aimed investigate anticancer activity lectin from P. using in silico vivo analysis. Methods: Different computational tools were used...
The objective of the study was to compare effect irrigation by municipal water (MW) and sewage (SW) on antioxidant detoxifying capacities some commercial Saudi date cultivars, Agwa, Anbr Safawi (<italic>Phoenix dactylifera</italic>L.).
The current study aimed to evaluate the probable protective effect of Lepidium sativum seeds (LSS) against CCl4 induced hepatic injury in New-Zealand rabbits. Rabbits were randomly divided into two main groups; group-A (noninjured group, n=15) was subgroups A1 (untreated control) and A2 A3 which received 200 & 400 mg/kg bw LSS, respectively, their diet daily. Group-B (injured n=30) subcutaneously injected with (0.5 ml/kg bw) starting from day one experiment equally 3 subgroups: B1 normal...
Background: Hypercholesterolemia is a major risk factor for development of atherosclerosis. The present study was conducted to evaluate the potential effect ginger oil alone or combined with rosemary as hypocholesterolemic agent in rats fed high fat diet. 
 Materials and methods: Healthy female albino (n=80) weighting about (150-180 g) were included this divided into two equal groups; Group (I): on basal (I) 4 subgroups each 10: (Ia): negative control. (Ib): Rats received i.p 2.5 g/Kg...
A drug repurposing strategy is an approach for identifying new therapeutic uses approved or investigational drugs. Thanks to the moderate cost of a compared bringing chemical entity market, rapidly gaining ground. The aim this work study anti-obesity effect disulfiram (DSF), irreversible aldehyde dehydrogenase inhibitor by Food and Drug Administration (FDA) treat chronic alcoholism since 1951.Thirty male Albino rats were randomly assigned six groups. G1, control group, was given standard...
Zika flavivirus is suspected to cause Guillain-Barre syndrome in adults and microcephaly, along with other congenital abnormalities infants. Presently, no vaccines or therapeutics are available. Here, we report novel compounds identified by high-throughput virtual screening of Maybridge chemical database molecular docking studies. We selected viral enzyme NS2B/NS3 serine protease as the therapeutic target because its important role replication. seven potential antiviral drug candidates their...