A5011675369- Hemoglobinopathies and Related Disorders
- Computational Drug Discovery Methods
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Curcumin's Biomedical Applications
- Long-Term Effects of COVID-19
- Hemoglobin structure and function
- Insect Resistance and Genetics
- Ion Transport and Channel Regulation
- Cancer therapeutics and mechanisms
- Erythrocyte Function and Pathophysiology
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Malaria Research and Control
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Cancer Immunotherapy and Biomarkers
- Blood groups and transfusion
- Natural Antidiabetic Agents Studies
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Iron Metabolism and Disorders
University of Jeddah
2018-2025
King Abdulaziz University
2017-2020
Daher (France)
2020
King Fahd Armed Forces Hospital
2018
King Fahad Hospital Jeddah
2017
Al-Farabi College
2014-2017
University of Leicester
2012-2014
Honey is a complex foodstuff found in nature which used without any processing. has been use medicine as well raw food since ancient times. Essentially, it blend of sugars especially fructose and glucose. The objectives the study were to determine major sugar composition pesticides contamination honey samples. Further, Hydroxy-methyl-furfuraldehyde (HMF) level was also determined ascertain freshness A total 14 samples collected from local market tested for fructose, glucose, sucrose, HMF...
At the molecular level, several developmental signaling pathways, such as Wnt/β-catenin, have been associated with initiation and subsequent progression of prostate carcinomas. The present report elucidated anti-cancerous attributes an anthraquinone, aloe-emodin (AE), against androgen-independent human cancer DU145 cells. cytotoxicity profiling AE showed that it exerted significant cytotoxic effects increased lactose dehydrogenase levels in cells (
Conflict reports exist on the impact of pyrethroid insecticides immune function and probable underlying mechanisms. This study evaluated effect an extensively used insecticide, fenpropathrin (FTN) (15 mg/kg b.wt), innate humoral components, blood cells, splenic oxidative status, mRNA expression CD3, CD20, CD56, CD8, CD4, IL-6, TNF-α, Caspase3 in a 60-day trial rats. Besides, possible defensive curcumin-loaded chitosan nanoparticle (CML-CNP) (50 b.wt) was evaluated. FTN exposure resulted...
Outdoor air pollution is a significant environmental health concern, linked to chronic respiratory diseases, heart conditions, and immunosuppression. One common indoor pollutant Bakhour, fragrant incense burned in many homes. Despite its widespread use, little research has explored the potential risks associated with Bakhour smoke exposure. This study investigated toxic effects of on immune system. Three popular types (Oud, Mabthoth, Mastic) were for four hours daily two weeks, exposing 20...
Platelet‐rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties. It is considered a source of growth factors that may induce tissue repairing and improve fibrosis. This product proven efficacy multiple studies, but effect on cisplatin‐induced nephrotoxicity not yet been elucidated. The present investigation was performed to estimate the protective impact platelet‐rich against cisplatin‐ (CP‐) evoked male rats....
Statins, including simvastatin (SMV), are commonly used for the control of hyperlipidaemia and have also proven therapeutic preventative effects in cardiovascular diseases. Besides that, there is an emerging interest their use as antineoplastic drugs demonstrated by different studies showing cytotoxic activity against cancer cells. In this study, SMV-loaded emulsomes (SMV-EMLs) were formulated evaluated MCF-7 breast The prepared using a modified thin-film hydration technique. A Box-Behnken...
Bleomycin is an effective antibiotic with a significant anticancer properties, but its use limited due to potential induce dose-dependent pulmonary fibrosis. Therefore, this study aimed assess the therapeutic of Capsaicin as additional treatment enhance patient tolerance compared antifibrotic drug Pirfenidone. Pulmonary fibrosis was induced in rats through by single intratracheal administration day zero, followed either or Pirfenidone for 7 days. After animals were sacrificed, their lungs...
Ovarian cancer is a leading cause of death due to the fact that most patients are diagnosed at an advanced stage(s) disease progression because it cannot be detected early stage. An immunogenic tumor and immunotherapy strongly pursued through targeting immune checkpoints. In previous study, signaling pathways their components have been shown as key factor for initiation, progression, finally scope diagnosis. Thus, in ovarian immune-based prognostic signature remains potential can explored...
Glioblastoma multiforme (GBM) is regarded as the most aggressive form of brain tumor delineated by high cellular heterogeneity; it resistant to conventional therapeutic regimens. In this study, anti-cancer potential garcinol, a naturally derived benzophenone, was assessed against GBM. During analysis, we observed reduction in viability rat glioblastoma C6 cells at concentration 30 µM extract (p < 0.001). Exposure garcinol also induced nuclear fragmentation and condensation, evidenced...
Coronavirus is an enclosed positive-sense RNA virus with club-like spikes extending from its surface. It most typically associated acute respiratory infections in humans, but capacity to infect many host species and cause multiple illnesses makes it a complicated pathogen. The frequent encounters between wild animals humans are typical of infection. zoonotic SARS-CoV MERS-CoV among the common causes serious humans.The main goal this research was look at gene expression profiles human samples...
Zika flavivirus is suspected to cause Guillain-Barre syndrome in adults and microcephaly, along with other congenital abnormalities infants. Presently, no vaccines or therapeutics are available. Here, we report novel compounds identified by high-throughput virtual screening of Maybridge chemical database molecular docking studies. We selected viral enzyme NS2B/NS3 serine protease as the therapeutic target because its important role replication. seven potential antiviral drug candidates their...
Background: Blood-related hereditary diseases are widespread in Eastern and SouthWestern regions of Saudi Arabia until recently. In this study, we used Na+, K+ATPase as an enzymatic indicator for the diagnosis diseases.Materials methods: Individuals with different blood (iron deficiency (n=13), anemia (n=14), thalassemia (n=16) sickle cell (n=12) were studied K+-ATPase activity plasma membrane red compared those healthy ones (n=20) same age gender living Jeddah, Arabia.Results: There was a...
Background: Studies have shown that Na+-K+ ATPase activity was altered in disrupted red blood cell membranes and this enzyme is believed to be the site of active transport Na+ K+ intact cells. The often referred as Na+- pump because it pumps out into against gradients with concomitant hydrolysis intracellular ATP.Objective: aim study find possibility using Na+-K+-ATPase a biomarker for diagnosis individuals different physiological conditions.Materials methods: determined samples collected...
Hypoxia most often occurs in cancer and the occurrence of hypoxia helps cells adapting different responses than normal such as activation those signaling pathways which regulate proliferation, angiogenesis, cell death. There are large number genes known to be associated with diverse biological processes their control coordination cancers, hypoxia-response differs. In this study our goal is understand impact alteration expression immune systems related its survival breast analyzed hallmarks...
Background: Colorectal cancer is the third most common type of and leading cause death worldwide. Major risk factors involved in development colorectal are increased dietary sources, genetics increasing age. Purpose study was to find role different variables progression cancer. Methodology: 50 blood samples from patients 20 control were collected. Serum separated by centrifugation. This serum assessed for several anti-oxidants like superoxide dismutase, glutathione, glutathione peroxidase,...
Introduction: Polycystic Ovarian Syndrome (PCOS), commonly found in 5% of all women reproductive age is a heterogeneous endocrine disorder which woman’s levels estrogen and progesterone are imbalance leading to the growth benign masses ovaries (ovarian cysts). Rotterdam criteria used diagnose PCOS include two three clinical features: 1) oligo- or anovulation, 2) hyperandroginism e.g., hirsutism, acne etc. 3) sonographic morphologic evidence polycystic ovaries. Aim: To investigate...
Abstract CD47 is a self-marker expressed on the surface of RBCs and work to prevent process phagocytosis. SIRPα ligand that phagocytic cells, such as macrophages, control removal dead/diseased cells. This study aimed examine expression PBMC cells in SCD patients apoptosis RBCs. We also measured levels pro-inflammatory cytokines correlated it with cell marker determine whether and/or played role promoting phenotype SCD. Whole blood samples were drawn from patients, healthy isolated stained...