A5074731186- Heavy Metal Exposure and Toxicity
- Drug Transport and Resistance Mechanisms
- Vitamin D Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Trace Elements in Health
- Hydrogen's biological and therapeutic effects
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Birth, Development, and Health
- Cancer therapeutics and mechanisms
- Circular RNAs in diseases
- Vitamin C and Antioxidants Research
- Coffee research and impacts
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Glycation End Products research
- Pharmacological Effects and Toxicity Studies
- Freezing and Crystallization Processes
- Tea Polyphenols and Effects
- Bone health and osteoporosis research
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
King Abdulaziz University
2016-2025
Dar Al-Hekma University
2020-2022
The King's College
2019
Institute of Biomedical Science
2019
Bridge University
2019
University of Surrey
2017
Queen's Medical Centre
2016
University of Nottingham
2012-2016
The heavy metals (HMs) lead and cadmium are persistent environmental pollutants capable of inducing ill-health in exposed individuals. One the primary sites accumulation potential damage from HMs is bone, we therefore examined acute effects on human bone osteoblasts vitro over a concentration range 0.1 μM to 1mM, for 3, 6, 12, 24, 48 hour exposures. Incubation with either or reduced cell viability concentrations exposure durations dependent manner, as measured using MTT LDH assays....
Background: Resveratrol (RES) is a phytochemical bioactive compound with suggested therapeutic benefits. Objective: The current work aimed to evaluate the anti-inflammatory effect of RES against palmitate (PA) induced lipotoxicity in raw 264.7 macrophages cell line. Methods: cells viability was assessed by lactate dehydrogenase assay. Then effects and PA on nitric oxide (NO), triglyceride (TG) content, cytokines release were studied. treated bioenergetics redox status evaluated via different...
Mercury (Hg) is known to be a hazardous toxin with significant negative impact on female reproduction through mechanisms that remain unclear. The carotenoid fucoxanthin (FX) an antioxidant several positive effects human health. This study aimed examine the potential protective role of FX in reducing Hg-induced bioenergetic disturbances ovarian granulosa cell line model. (methods briefly) Hg was found reduce viability cells concentration-dependent manner, estimated 72-hour EC50 10µM. In...
Abstract This study investigates the neuroprotective effects of fucoxanthinol (FXL) against toxic activities two compounds known to induce neurotoxic in humans and animals. MPTP (1-methyl- 4-phenyl- 1,2,3,6-tetrahydropyridine) induces Parkinson’s disease (PD)-like phenotypes by inhibiting mitochondrial complex I dopaminergic neurons. Chlorpyrifos (CPF), another agent, is associated with acute long-term neurotoxicity primarily through acetylcholinesterase (AChE) inhibition. FXL demonstrated...
Background . Many epidemiological studies have shown that vitamin D deficiency is associated with various types of human cancers. The biological action and its metabolites mediated by the transcription factor receptor (VDR). VDR gene highly expressed in colon involved many functions. aim current study was to assess relationship between serum metabolite calcium levels polymorphisms normal colorectal cancer (CRC) patients. Methods Fifty Saudi CRC patients fifty controls were enrolled study....
Acute or chronic exposures to pesticides have been linked neurotoxicity and the potential development of neurodegenerative diseases (NDDs). This study aimed consider three widely utilized pesticides: malathion, chlorpyrifos, paraquat within hippocampus (HC), corpus striatum (CS), cerebellum (CER), cerebral cortex (CC). Neurotoxicity was evaluated at relatively low, medium, high pesticide dosages. All inhibited acetylcholinesterase (AChE) neuropathy target esterase (NTE) in each brain...
Background: Long noncoding RNAs (lncRNAs) have recently been recognized as a new layer of biological regulation. They participate in mRNA regulation and may be useful prognostic factors drug targets. Colorectal cancer (CRC) is common tumor that characterized by its high mortality rate. Despite improvements screening CRC, the prognosis still poor. Therefore, there an urgent need to develop effective biomarkers for detection CRC. This study was designed measure expression several oncogenic...
The diabetogenic effects of metals including lead (Pb), mercury (Hg), cadmium (Cd), and molybdenum (Mo) have been reported with poorly identified underlying mechanisms. current study assessed the effect on roles oxidative stress, apoptosis, inflammation in beta pancreatic cells isolated from CD-1 mice, via different biochemical assays. Data showed that tested were cytotoxic to impaired glucose stimulated insulin secretion (GSIS). This was associated increased reactive oxygen species (ROS)...
Paraquat (PQ), rotenone (RO), and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) are neurotoxicants that can damage human health. Exposure to these has been linked neurodegeneration, particularly Parkinson's disease. However, their mechanisms of action have not fully elucidated, nor the relative vulnerability neuronal subtypes exposures. To address this, current study investigated cytotoxic effects PQ, RO, MPTP on cellular bioenergetics oxidative stress undifferentiated neuroblastoma...
Diabetes mellitus risk is increased by prolonged usage of antidepressants (ADs). Although various mechanisms are suggested for their diabetogenic potential, whether a direct effect ADs on pancreatic β-cells involved unclear. We examined this idea 3 ADs: paroxetine, clomipramine and, with particular emphasis, fluoxetine, insulin secretion, mitochondrial function, cellular bioenergetics, KATP channel activity, and caspase activity in murine human cell-line models β-cells. Metabolic assays...
Colorectal cancer (CRC) is one of the leading causes mortality and morbidity worldwide, there has been a significant increase in incidence CRC recent decades. Therefore, an urgent need to identify blood biomarkers that can be used for early diagnosis. It not yet clear whether level vitamin D its receptor, receptor (VDR), are helpful factors diagnosis CRC. study focuses on determining VDR serum level's contribution other chemical parameters risk A total 189 Saudi participants (66 patients 123...
Zamzam water is naturally alkaline and rich in a variety of minerals which may represent powerful tool for cancer therapy. In this research, the cytotoxic effects were investigated human lung (A549) cell line compared with skin fibroblasts (HSF).Two different preparations used: Z1, pH adjusted to 7.2 Z2, no adjustment. The both treatments on morphology A549 HSF lines investigated. viability cells was identified by MTT assay trypan blue exclusion. Detection apoptotic cycle analyses determined...
Tramadol (TR), a commonly prescribed pain reliever for moderate to severe pain, has been associated with kidney damage. This study investigates TR-induced nephrotoxicity mechanisms, focusing on its effects renal proximal tubular cells (PTCs). The findings demonstrate that TR disrupts PTC bioenergetic processes, leading oxidative stress and inflammation. Significant toxicity PTCs was observed estimated effective concentration 50 values of 9.8 11.5 µM based...