A5068392011- Natural Antidiabetic Agents Studies
- Protein Hydrolysis and Bioactive Peptides
- Advanced Glycation End Products research
- Essential Oils and Antimicrobial Activity
- Pomegranate: compositions and health benefits
- Renal and related cancers
- Biochemical effects in animals
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
- Synthesis and biological activity
- Plant Parasitism and Resistance
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Biofuel production and bioconversion
- Clostridium difficile and Clostridium perfringens research
- Date Palm Research Studies
- Paraoxonase enzyme and polymorphisms
- Drug-Induced Hepatotoxicity and Protection
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Medicinal Plants
- Phytase and its Applications
- Botanical Research and Applications
- Microscopic Colitis
- Renal cell carcinoma treatment
- Phytochemistry and Biological Activities
King Abdulaziz University
2016-2024
King Abdul Aziz University Hospital
2017
Hypercholesterolemia is one of the most important risk factors for development cardiovascular diseases. The composition gut microbiota (total microbes residing in gut) impacts on cholesterol and lipid metabolism. On contrary, alterations response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing evaluate bacterial community 15 untreated hypercholesterolemic patients (HP) 27...
Breast cancer (BC) is one of the most common cancers in women and a major cause female cancer-related deaths. BC multifactorial disease caused by dysregulation many genes, raising need to find novel drugs that function targeting several signaling pathways. The antitumoral drug thymoquinone (TQ), found black seed oil, has multitargeting properties against This study evaluated inhibitory effects TQ on MCF7 T47D human breast cell lines its antitumor activity induced single oral dose (65 mg/kg)...
Urolithins are gut microbiota-derived polyphenol metabolites, produced following the consumption of pomegranate, berries, and nuts. Recent studies have shown potentials these metabolites on reducing triglycerides accumulation in cultured hepatocytes adipocytes. In this study, we investigated ability both urolithin A (Uro-A) B (Uro-B) to attenuate obesity associated symptoms a high-fat diet-induced model rats.Twenty-four male Wistar rats were randomly assigned four groups. Group 1 was fed...
Bioactive peptides produced from natural sources are considered as strategic target for drug discovery. Hyperglycemia caused protein glycation alters the structure of many tissues that impairs their functions and lead complications diseases in human body. This study investigated bioactive red brown Lens culinaris might inhibit to prevent diabetic complications. In this study, hydrolysates were prepared by tryptic digestion, using an enzyme/substrate ratio 1:20 (g/g), at 37°C, 12 hr then...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
In this study, we investigated the inhibitory effects of m-coumaric acid on glycosylation proteins in retinas diabetic rats. Male rats were divided into two main groups, Group I (normal control) and II (diabetic); was further four subgroups: IIa (diabetic control), IIb given orally [150 mg/kg, body weight (bw)/day]), IIc HCA [300 mg/kg bw/day]), IId insulin [10 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, data obtained suggested that reduced glucose glycated...
Chemotherapy shows some promising results in the inhibition of cancer, but resistance to chemotherapy and its severe side effects may occur due course, resulting only restricted narrow benefits. Therefore, there is a pressing need find alternative chemotherapeutic drugs for combating cancers. Plants have been used since ages medicine, by dawn 19th century, various potent anti-cancer products derived from plants. Strigolactones (SLs) are novel class phytohormones involved regulating branching...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Wilms tumor 1 (WT1) gene has recently shown a role in gliomagenesis, making it potential immunotherapy target glioblastomas. We aimed to investigate the most sensitive method detect WT1 expression glioblastoma and explore relationship between expression, IDH1 mutation recurrence interval.Clinical data were collected from 44 patients with glioblastomas, treated adjuvant therapies. was assessed all cases using immunohistochemistry (IHC), while its 13 clustered samples polymerase chain reaction...
Nigella sativa L. seed commonly known as black seed, extensively used a folk medicine in Middle East and Asian subcontinent. Traditionally it is an adjunct therapy along with modern to counter the adverse effects. Pure thymoquinone or isolated compounds are not free from The present study was undertaken evaluate N. seeds powder impact on fluconazole (FLZ) induced toxicities liver kidneys. Male Wistar rats were acclimatized, divided into four groups each group six animals. Experimental...
Abstract Background The Wilms tumor 1 ( WT1 ) gene has recently been shown to play a role in gliomagenesis, making it potential immunotherapy target glioblastomas. We aimed investigate the most sensitive method detect expression glioblastoma and explore relationship between isocitrate dehydrogenase-1 IDH1 mutation. Methods Clinical biological data were collected from 44 patients with totally resected glioblastomas, treated adjuvant therapies, period 2015 2019. protein was assessed all cases...