A5001984079- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- DNA and Nucleic Acid Chemistry
- Immune Cell Function and Interaction
- Alkaloids: synthesis and pharmacology
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Thyroid Disorders and Treatments
- Psychedelics and Drug Studies
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- COVID-19 epidemiological studies
- Employee Performance and Motivation
- Management and Optimization Techniques
- Livestock and Poultry Management
- Neurotransmitter Receptor Influence on Behavior
- Nanoparticle-Based Drug Delivery
- Impact of Technology on Adolescents
- Cancer Cells and Metastasis
- Phytochemicals and Medicinal Plants
University of Alberta
2020-2025
Pharmaceutical Biotechnology (Czechia)
2025
King Abdulaziz University
2017-2020
Southeast University
2015-2017
• As the coronavirus outbreak quickly surges worldwide, many countries are adopting non-therapeutic preventive measures, which include travel bans, remote office activities, country lockdown, and, most importantly, social distancing However, these measures face challenges in Bangladesh, a lower-middle-income economy with one of world's densest populations Social is difficult areas country, and minimal resources has, it would be extremely challenging to implement mitigation Mobile...
Worldwide Internet addiction is a newly emerging mental health and social issue among the youths causing neurological complications, psychological disturbances problems. addicts make urgency more vital than family, friends work. Several studies exposed that anxiety, backache, blurred vision, dry eyes, headache, sleep disturbance, depression, poor academic performance etc. are results of addiction. Therefore, objective this study was to determine as well its distress depression university...
Neurochemistry refers to the chemical processes that occur in brain and nervous system. This section of study determines how neurochemicals influence network neural operation. The transfers numerous information via neurons communicate. main role neurochemistry activities takes place brain, which allows it perform actions. Foundation is a little bit different from man several things can play levels various neurotransmitters brain. It supposed differences chemistry may accountable for variety...
Small interfering RNA (siRNA) therapy in acute myeloid leukemia (AML) is a promising strategy as the siRNA molecule can specifically target proteins involved abnormal cell proliferation. The development of clinically applicable method for delivering molecules imperative due to challenges effectively into cells. We investigated delivery AML MOLM-13 cells with use two lipid-substituted polyethyleneimines (PEIs), commercially available reagent (Prime-Fect) and recently reported improved lipid...
A previous study has demonstrated the benefit of modification polyethylenimine (PEI1.2k) by lipids through a p-hydroxyphenylacetic acid (PHPA) linker and polyanion (PA), which is now extended in this report to several primary cells. The formulated binary (lipopolymer/NAs) ternary (lipopolymer/NAs/PA) complexes displayed no significant toxicity (MTT/hemolysis assay). pDNA/mRNA with PEI1.2k-PHPA-Lin9 PEI1.2k-PHPA-Lau5-Ole5 lipopolymers showed gene expression levels higher than those other...
Small interfering RNAs (siRNAs) have emerged as a powerful tool to manipulate gene expression in vitro. However, their potential therapeutic application encounters significant challenges, such degradation vivo, limited cellular uptake, and restricted biodistribution, among others. This study evaluates the siRNA delivery efficiency of three different lipid-substituted polyethylenimine (PEI)-based carriers, named Leu-Fect A–C, organs including xenograft tumors, when injected into bloodstream...
Amphetamines are central nervous system (CNS) stimulants and belong to psychoactive drugs that affect chemicals in the brain, nerves exert a constant contribution hyperactivity impulse control. The communal group of amphetamines comprises amphetamine, dextroamphetamine methamphetamine. show its action on mesolimbic dopaminergic reward by inducing release dopamine some extent norepinephrine, synaptic clefts nucleus accumbens other terminal areas. They offer not only sense euphoric state, but...
Overexpression and persistent activation of STAT5 play an important role in the development progression acute lymphoblastic leukemia (ALL), most common pediatric cancer. Small interfering RNA (siRNA)-mediated downregulation represents a promising therapeutic approach for ALL to overcome limitations current treatment modalities such as high relapse rates poor prognosis. However, effectively transport siRNA molecules target cells, potent carriers is utmost importance surpass hurdles delivery....
The therapeutic potential of small interfering RNAs (siRNAs) in gene-targeted treatments is substantial, but their suboptimal delivery impedes widespread clinical applications. Critical among these the inability siRNAs to traverse cell membranes due anionic nature and high molecular weight. This limitation particularly pronounced lymphocytes, which pose additional barriers smaller size scant cytoplasm. Addressing this, we introduce an innovative lipid-conjugated polyethylenimine lipopolymer...
This study was aimed to economic evaluate of broiler farms in Egypt by using data Envelopment analysis (DEA).A total number 50 farm records were collected from different within provinces (Sharkia, Dakhlia and Gharbia).The a cross-section survey farmers random sample face-to-face questionnaire.Farms having up 5000 birds classified as small, those with 5000-10000birds medium over 10000 large.Different efficiencies analyzed (DEA) also parameters SPSS.Results showed that, for the small farms,...
Alangium salvifolium wang is a medicinal plant of the Alanginaceae family which was used as traditional medicine to cure or prevent variety ailments. The aim study investigate and compare phytochemical profiles, antioxidant anticholinesterase effects ethanol (EASR), dichloromethane (DASR), chloroform (CASR) aqueous (AASR) extracts A. root. Phytochemical screening done by using qualitative methods whereas total phenol content (TPC), flavonoid (TFC) flavonol (TFlC) were determined...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Among all cancer types, colorectal is the third most common in men and second women globally. Generally, risk of increases with age, modulated by various genetic alterations. Alterations immune response serve a significant role development cancer. In primary cells express variety inhibitory molecules that dampen against tumor cells. Additionally, few reports have demonstrated classical chemotherapy promotes immunosuppressive microenvironment both tissues This study assessed expression levels...
Recently, vitamins have been shown to act as epigenetic modifier. Cancer cells exhibit transcriptional downregulation of NK group 2D ligands (NKG2DLs) through repressive methylation and are largely resistant cell-mediated eradication. We herein investigated the potential recently reported epigenome modifying A, C, E in inducing expression epigenetically silenced NKG2DLs cancer cells. Based on cell viability assay three concentrations, i.e., 25, 50, 100 µg/ml all were selected for treatment....
Abstract In contrast to exploiting proteins as targets like most conventional drugs and tyrosine kinase inhibitors (TKI), that are rendered futile in the face of emerging drug resistance, RNA Interference (RNAi) exerts its therapeutic action towards disease-driving aberrant genes. To realize potential RNAi, major challenge is efficiently deliver mediator small interfering (siRNA) molecules. this study, we explored feasibility using aliphatic lipid-grafted polymers (lipopolymers) for delivery...
Background: Colorectal cancer (CRC) is the third most diagnosed among men and second women globally. Generally, with age, risk of this grows happened by various genetic alterations. The immune system plays an important role against CRC that provides a new means to therapy. Our research focused on relative expression level ten different genes namely IFNγ, CD 273, CD274, PD-1, β2M, CD3e, CD28, HLA-A, ICAM 1, CTLA 4 which are known play in regulation during cancers. We hypothesize...