A5091324918- Mosquito-borne diseases and control
- Malaria Research and Control
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Enzyme Production and Characterization
- Viral Infections and Vectors
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Psidium guajava Extracts and Applications
- Bioinformatics and Genomic Networks
- Piperaceae Chemical and Biological Studies
- Phytoplasmas and Hemiptera pathogens
- Plant tissue culture and regeneration
- Influenza Virus Research Studies
- Silymarin and Mushroom Poisoning
- Plant Gene Expression Analysis
- Transgenic Plants and Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Dengue and Mosquito Control Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Research on Leishmaniasis Studies
- Laser-Ablation Synthesis of Nanoparticles
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
University of Jeddah
2018-2024
The Pirbright Institute
2019
Mohammad Ali Jauhar University
2016
Jamia Millia Islamia
2011
Lung cancer presents one of the most challenging carcinomas with meager 5-year survival rates (less than 20%), high metastasis and recurrence due to chemo- radio- resistance. An alternative or complementation existing prognosis modalities is use phytochemicals such as silibinin, which targets essential cytokines, angiogenic factors transcription for a profound anti-tumor effect. However, problems low solubility in an aqueous physiological environment, poor penetration, metabolism rapid...
Abstract The BLM helicase protein plays a vital role in DNA replication and the maintenance of genomic integrity. Variation gene resulted defects repair mechanism was reported to be associated with Bloom syndrome (BS) cancer. Despite extensive investigation proteins humans, no attempt has previously been made comprehensively analyse single nucleotide polymorphism (SNPs) gene. In this study, comprehensive analysis SNPs on performed identify, characterize validate pathogenic using...
Our work was devoted to studying the effect of different concentrations Mentha spicata aqueous extract on green synthesis silver nanoparticles (AgNPs) in order obtain most effective these for bacteria inhibitory activity. Different M. (0.25, 0.50, 0.75, and 1.00 mM) were used as biological solvent synthesize AgNPs by means reduction method. The crystal structure morphology NPs characterized UV–vis spectra, X-ray diffraction (XRD), scanning electron microscopy (SEM). inhibition Escherichia...
Enzyme immobilization is one of the most important techniques for industrial applications. It makes immobilized enzyme more stable and advantageous than free form in different aspects. α-Amylase was on 4% cyanuric chloride-activated amidoximated acrylic fabric at pH 7.0 with (79%) maximum efficiency. A field emission scanning electron microscope Fourier transform infrared were used to confirm process. Even after being recycled 10 times, lost just 28% its initial activity. Owing...
Ovarian cancer is a leading cause of death due to the fact that most patients are diagnosed at an advanced stage(s) disease progression because it cannot be detected early stage. An immunogenic tumor and immunotherapy strongly pursued through targeting immune checkpoints. In previous study, signaling pathways their components have been shown as key factor for initiation, progression, finally scope diagnosis. Thus, in ovarian immune-based prognostic signature remains potential can explored...
The emergence of a new coronavirus (CoV), severe acute respiratory syndrome 2 (SARS-CoV-2), responsible for disease in humans termed 2019 (COVID-19), became global threat health and the economy. SARS-CoV-2 genome is about 29,800-nucleotide-long plus-strand RNA that can form functionally important secondary higher-order structures called cis -acting elements. These elements interact with viral proteins, host or other RNAs be involved regulating translation replication processes encapsidation...
Extracellular vesicles are small single lipid membrane entity secreted by eukaryotic and prokaryotic cells play an important role in intercellular signaling nutrient transport. The last few decades have witnessed a plethora of research on these owing to their ability answer many hidden facts at the supramolecular level. These extracellular attracted researchers because they act as shuttle agents transfer biomolecules/drugs between cells. Recently, studies shown application exosomes tumor...
Zika flavivirus is suspected to cause Guillain-Barre syndrome in adults and microcephaly, along with other congenital abnormalities infants. Presently, no vaccines or therapeutics are available. Here, we report novel compounds identified by high-throughput virtual screening of Maybridge chemical database molecular docking studies. We selected viral enzyme NS2B/NS3 serine protease as the therapeutic target because its important role replication. seven potential antiviral drug candidates their...
Dengue virus is a potential source of propagating dengue hemorrhagic fever. This leads to fever/dengue shock syndrome, benign and severe syndrome due its infection, there occurs alterations at multiple levels such as gene expression pathway levels. So, it critical understand the pathogenesis infection in terms associated functions.For this purpose, here, we have analyzed temporal profiling for fever dataset 12, 24, 48 hours.The outcome appears that evolves differently different time periods...
Hypoxia most often occurs in cancer and the occurrence of hypoxia helps cells adapting different responses than normal such as activation those signaling pathways which regulate proliferation, angiogenesis, cell death. There are large number genes known to be associated with diverse biological processes their control coordination cancers, hypoxia-response differs. In this study our goal is understand impact alteration expression immune systems related its survival breast analyzed hallmarks...
Plants infected by a wide range of viruses often cause important agronomic and economic losses worldwide. Detection plant is becoming more challenging as globalisation trade, particularly the ornamental plants, potential effects climate change facilitate movement their vectors, thereby transforming diagnostic landscape. Under such circumstances, detection at premature stages infection use rapid, sensitive accurate methods seems crucial to ensure safe sustainable agriculture reduces losses....
This study was aimed to evaluate the relationship between growth hormone (GH) gene polymorphism and milk production in Najdi sheep. Two hundred ewes were used determine daily yield (DMY). The complete CDS of sheep GH is1950 length, GenBank acc. no. KU310891.1. protein consists 217 amino acids ALT22407.1 with conversion acid arginine number 121 lysine (R121K). A novel five SNPs detected (G871A, A1259C, G1383A, A1486G A1509G). significant association genotypes found this study. regression...
The Dengue virus (DENV) has been increasingly recognized as a prevalent viral pathogen responsible for global transmission of infection. It established that DENV's NS5 methyltransferase (MTase) controls replication. As result, MTase is considered potentially useful drug target DENV. In this study, the two phases virtual screening were conducted using ML-based QSAR model and molecular docking to identify potential compounds against Four medicinal plants [Aloe vera, Cannabis sativa (Hemp),...
The Japanese encephalitis virus, (JEV), is a flavivirus mostly transmitted by Culex mosquitoes present in Southeast Asia and the Western Pacific region. Ardeid-wading birds are natural reservoir of JEV; nonetheless, pigs frequently key amplifying host during epidemics human populations. Although more domestic animals wildlife JEV hosts, it unclear how these fit into ecology epidemiology virus. Even though there no specific therapy, vaccines available to prevent this infection. However,...
(JE) is a single-stranded, mosquito-borne, positive-sense RNA flavivirus that causes one of the most severe encephalitides. There are treatments available for those who contact this illness; however, there no known cures. This disease has 30% fatality rate, and people survive, 30-50% develops neurologic psychiatric sequelae. The JE virus genome size 10.98 kb contains two coding DNA sequences (CDS), genes, 15 mature peptides; CDS polyprotein 10.3 kb. In study, we used 29 genomics reported...