A5100663015- Gut microbiota and health
- Reproductive Biology and Fertility
- Clostridium difficile and Clostridium perfringens research
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Reproductive Physiology in Livestock
- Virus-based gene therapy research
- Groundwater and Isotope Geochemistry
- RNA Interference and Gene Delivery
- Microbial Community Ecology and Physiology
- Oral microbiology and periodontitis research
- Genomics and Phylogenetic Studies
- Nanoparticles: synthesis and applications
- Dental Health and Care Utilization
- Fungal Biology and Applications
- Tuberculosis Research and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal motility and disorders
- Reproductive System and Pregnancy
- Pharmaceutical and Antibiotic Environmental Impacts
- Ovarian function and disorders
- Sperm and Testicular Function
- Ecology and Vegetation Dynamics Studies
- Pharmacological Effects of Natural Compounds
Abdul Wali Khan University Mardan
2022-2025
Macau University of Science and Technology
2017-2024
Jinnah Sindh Medical University
2023-2024
Aligarh Muslim University
2012-2024
National Institute of Biotechnology
2024
University of Engineering & Management
2024
Dalian Medical University
2022-2024
Minzu University of China
2024
Lanzhou University
2024
Gansu Provincial Hospital
2024
Objective Programmed death 1 and its ligand (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved. Gut microbiota plays a crucial role in sensitisation Panax ginseng has been shown possess immunomodulatory potential. In this study, we aimed investigate whether combination treatment of polysaccharides (GPs) αPD-1 monoclonal antibody (mAb) could sensitise by modulating gut microbiota. Design Syngeneic mouse models were...
Abstract The aim of the present study was to investigate alterations in gut microbiota associated with hypercholesterolemia and treatment atorvastatin, a commonly prescribed cholesterol-lowering drug. In this study, seven experimental groups rats were developed based on diets [high-fat diet (HFD) normal chow (NCD)] various doses atorvastatin HFD NCD groups. 16S rRNA amplicon sequencing used analyze microbiota. Atorvastatin significantly reduced cholesterol level treated rats. Bacterial...
Abstract Studies showed that manipulation of gut microbiota (GM) composition through the treatment prebiotics could be a novel preventive measure against colorectal cancer (CRC) development. In this study, for first time, we assessed non-toxic doses triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd) – as effectively reinstated dysbiotic-gut microbial intestinal microenvironment in an Apc Min/+ mice model. Rb3 Rd reduced size number polyps accompanied with downregulation oncogenic...
Hypercholesterolemia is one of the most important risk factors for development cardiovascular diseases. The composition gut microbiota (total microbes residing in gut) impacts on cholesterol and lipid metabolism. On contrary, alterations response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing evaluate bacterial community 15 untreated hypercholesterolemic patients (HP) 27...
Food and Drug Administration (FDA, USA)-approved category B antibiotics are commonly prescribed to treat infections during pregnancy. The aim of this study was investigate antibiotic-induced changes in gut microbiota (GM) that occur 16S rRNA amplicon deep-sequencing method used analyse the effect (azithromycin, amoxicillin cefaclor) on GM pregnancy using a rat model. composition substantially modulated by administration. Firmicutes, Bacteroidetes, Proteobacteria, Chlamydiae, Actinobacteria...
Abstract MicroRNAs regulate post-transcriptional gene expression and play important roles in multiple cellular processes. In this study, we found that miR-421 suppresses kelch-like ECH-associated protein 1(KEAP1) by targeting its 3′-untranslated region (3′UTR). A Q-PCR assay demonstrated is overexpressed non-small cell lung cancer (NSCLC), especially A549 cells. Consistently, the level of was higher clinical blood samples from patients than those normal healthy donors, suggesting an...
Abstract Background Osteoporosis is a metabolic bone disorder that leads to low mass and microstructural deterioration of tissue increases fractures. Resveratrol, natural polyphenol compound, has pleiotropic effects including anti-oxidative, anti-aging, anti-cancer effects. Resveratrol also roles in increasing osteogenesis upregulating mitochondrial biogenesis marrow-derived mesenchymal stem cells (BM-MSCs). However, it still unclear resveratrol can enhance osteogenic differentiation or...
Ongoing extensive research in the field of gut microbiota (GM) has highlighted crucial role gut-dwelling microbes human health. These possess 100 times more genes than genome and offer significant biochemical advantages to host nutrient drug absorption, metabolism, excretion. It is increasingly clear that GM modulates efficacy toxicity drugs, especially those taken orally. In addition, intra-individual variability been shown contribute response biases for certain therapeutics. For instance,...
Fluoride is vital for dental health, promoting enamel remineralization and reducing decay risk. However, both low high fluoride levels in drinking water pose health risks. Jhunjhunu district, Rajasthan, exhibits significant spatial variability concentrations (0.3–1.4 ppm), resulting issues. Study Area Methodology: • Conducted Udaipurwati, Chirawa, Pilani blocks across 68 villages. Villages categorized into four groups based on (<0.5, 0.5–1, 1–1.05, ≥2 ppm). Data collected through...
ABSTRACT Kaempferol (Kae), as a homologous flavonoid, plays pivotal role in human nutrition and disease treatment. This study endeavors to elucidate the vivo metabolism of Kae its potential modulate interplay between bile acids (BAs) gut microbiota (GM). After administration, we analyzed pharmacokinetics, BA levels, drug metabolic enzymes (DMEs) amount using LC–MS/MS. Subsequently, checked gene protein expression with qRT‐PCR western blot studied changes GM 16S rRNA sequencing, accompanying...
Cardiometabolic diseases (CMDs), particularly cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and chronic kidney (CKD), emerged as primary contributors to global morbidity mortality. In addition traditional factors, recent studies demonstrated that blood microbiomes may also promote the development or progression of these CMDs. Traditionally, was considered sterile; however, notion a sterile environment has been challenged by findings demonstrating presence microbiome in both...