We discuss the observational consequences of black hole spin in X-ray binaries within framework standard thin accretion disk model. When compared with theoretical flux distribution from surface a surrounding Kerr hole, observed properties Galactic superluminal jet sources, GRO J1655-40 and GRS 1915+105, strongly suggest that each contains spinning rapidly same direction as disk. show, however, some other an ultrasoft component probably harbor only non- or slowly holes, we argue those no...

We have collected the available data from literature and public archives covering past two decades for long-term X-ray optical light curves of nova (XN) outbursts, carry out first time a systematic, statistical study XN which are classified into 5 morphological types. Basic curve parameters, e.g., outburst peak flux, amplitude, luminosity, rise decay timescales, observed expected durations, total energy radiated, tabulated discussed. The timescales found to flat distribution while much...

Abstract Development of real‐time non‐invasive imaging probes to assess infiltration and activation cytotoxic T cells (CTLs) is critical predict the efficacy cancer immunotherapy, which however remains challenging. Reported here an activatable semiconducting polymer nanoprobe (SPNP) for near‐infrared fluorescence (NIRF) photoacoustic (PA) a biomarker (granzyme B) associated with CTLs. SPNP comprises (SP) conjugated granzyme B cleavable dye‐labeled peptide as side chain, both emit NIRF PA...

Abstract Photoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth enhanced spatial resolution relative to traditional optical imaging, thus hold great promise for clinical applications. However, existing PA often encounter the issues of slow body excretion low‐signal specificity, which compromise their capability in vivo detection. Herein, a fluoro‐photoacoustic polymeric renal reporter (FPRR) is synthesized real‐time drug‐induced acute kidney...

Afterglow imaging holds great potential for ultrasensitive biomedical imaging. As it detects photons after the cessation of real-time light excitation, autofluorescence can therefore be effectively eliminated. However, afterglow is still in its infant stage due to lack agents with satisfactory lifetime, biocompatibility, and high luminescence brightness, particularly near-infrared region vivo applications. To address these issues, this study first time reports chlorin nanoparticles (Ch-NPs)...

Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia-tolerant superiority over the commonly used II pathway. A few photosensitizers are exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity low-efficient theranostics. To resolve this issue, herein aminopeptidase N (APN)-activated phototheranostic probe (CyA) is reported for anti-hypoxic PDT in conjunction with...

Spontaneous hemodynamic signals fluctuate coherently within many resting-brain functional networks not only in awake humans and lightly anesthetized primates but also animals under deep anesthesia characterized by burst–suppression electroencephalogram (EEG) activity unconsciousness. To understand the neural origin of spontaneous fluctuations such a state, epidural EEG cerebral blood flow (CBF) were simultaneously recorded from bilateral somatosensory cortical regions rats with...

Discriminative detection of invasive and noninvasive breast cancers is crucial for their effective treatment prognosis. However, activatable probes able to do so in vivo are rare. Herein, we report an polymeric reporter (P-Dex) that specifically turns on near-infrared (NIR) fluorescent photoacoustic (PA) signals response the urokinase-type plasminogen activator (uPA) overexpressed cancer. P-Dex has a renal-clearable dextran backbone linked with NIR dye caged uPA-cleavable peptide substrate....

Cancer-associated fibroblasts (CAFs) are the major components of tumor-associated matrix and play an important role in tumor progression immunosuppression. Therefore, precise theranostics CAFs beneficial for CAFs-targeted therapies. However, imaging agents enabling have been rarely exploited. To tackle this issue, a molecular pro-theranostic probe (FMP) with activatable fluorescence, photoacoustic (PA) imaging, photodynamic therapy (PDT) is developed response to fibroblast activation protein...

Afterglow luminescence imaging probes, with long-lived emission after cessation of light excitation, have drawn increasing attention in biomedical field owing to their elimination autofluorescence. However, current afterglow agents always suffer from an unsatisfactory signal intensity and complex systems consisting multiple ingredients. To address these issues, this study reports a near-infrared (NIR) luminophore (TPP-DO) by chemical conjugation substrate photosensitizer acting as both...

Abstract Activatable afterglow luminescence nanoprobes enabling switched “off-on” signals in response to biomarkers have recently emerged achieve reduced unspecific and improved imaging fidelity. However, such always use a biomarker-interrupted energy transfer obtain an activatable signal, which necessitates strict distance requisition between donor acceptor moiety (<10 nm) hence induces low efficiency non-feasibility. Herein, we report organic upconversion cocktail nanoparticles (ALCNs)...

Afterglow imaging holds great promise for ultrasensitive bioimaging due to its elimination of autofluorescence. Self-sustaining afterglow molecules (SAMs), which enable all-in-one photon sensitization, chemical defect formation and generation, possess a simplified, reproducible, efficient superiority over commonly used multi-component systems. However, there is lack SAMs, particularly those with much brighter near-infrared (NIR) emission structural flexibility building high-contrast...

Estimates made in the 1970s indicated that a supernova occurring within tens of parsecs Earth could have significant effects on ozone layer. Since time, improved tools for detailed modeling atmospheric chemistry been developed to calculate depletion, and advances also theoretical supernovae resultant gamma-ray spectra. In addition, we now better knowledge occurrence rate Galaxy spatial distribution progenitors core-collapse supernovae. We report here results two-dimensional model...

We report on a series of 20, ~105 counts s-1, 0.125 ms time-resolution Rossi X-Ray Timing Explorer observations the Z-source and low-mass X-ray binary Scorpius X-1. Twin kilohertz quasi-periodic oscillation (QPO) peaks are obvious in nearly all observations. find that peak separation is not constant, as expected some beat-frequency models, but instead varies from ~310 to ~230 Hz when centroid frequency higher ~875 ~1085 Hz. detect none additional QPO at frequencies predicted photon bubble...

A series of lanthanide anionic metal–organic frameworks, [NH2(CH3)2][Ln(MDIP)(H2O)] (Ln = Pr (1), Nd (2), Sm (3), Eu (4), Gd (5), Tb (6), Dy (7); H4MDIP methylenediisophthalic acid) and [NH2(CH3)2][Ln(MDIP)(H2O)]·0.5NH(CH3)2 Er (8), Tm (9), Yb (10)), have been synthesized characterized. In compounds 1–7, the adjacent Ln3+ ions are intraconnected to form infinite metal-carboxylate oxygen chain-shaped building blocks along [001] direction. 8–10, MDIP ligands bridge dinuclear centers...

Abstract Development of real‐time non‐invasive imaging probes to assess infiltration and activation cytotoxic T cells (CTLs) is critical predict the efficacy cancer immunotherapy, which however remains challenging. Reported here an activatable semiconducting polymer nanoprobe (SPNP) for near‐infrared fluorescence (NIRF) photoacoustic (PA) a biomarker (granzyme B) associated with CTLs. SPNP comprises (SP) conjugated granzyme B cleavable dye‐labeled peptide as side chain, both emit NIRF PA...

Abstract Discriminative detection of invasive and noninvasive breast cancers is crucial for their effective treatment prognosis. However, activatable probes able to do so in vivo are rare. Herein, we report an polymeric reporter (P‐Dex) that specifically turns on near‐infrared (NIR) fluorescent photoacoustic (PA) signals response the urokinase‐type plasminogen activator (uPA) overexpressed cancer. P‐Dex has a renal‐clearable dextran backbone linked with NIR dye caged uPA‐cleavable peptide...

Molecular mechanisms permitting the establishment and dissemination of a virus within newly adopted host species are poorly understood. Mouse hepatitis (MHV) strains (MHV-A59, MHV-JHM, MHV-A59/MHV-JHM) were passaged in mixed cultures containing progressively increasing concentrations nonpermissive Syrian baby hamster kidney (BHK) cells decreasing permissive murine DBT cells. From MHV-A59/MHV-JHM infection, variant viruses (MHV-H1 MHV-H2) which replicated efficiently BHK isolated. Under...

In the context of black hole spin in X-ray binaries, we propose that certain types quasi-periodic oscillations (QPOs) observed light curves binaries (BHBs) are produced by modulation at precession frequency accretion disks, because relativistic dragging inertial frames around spinning holes. These QPOs tend to be relatively stable their centroid frequencies. They have been range a few hertz hundred for several holes with dynamically determined masses. By comparing computed disk QPO, can...

An electrically controlled beam-scanning circularly polarized leaky-wave antenna is presented by cascading multiple unit cells of a composite right/left-handed transmission line (CRLH-TL) structure. The CRLH-TL cell consists two parts: varactor diodes (two series ones and shunt one), which enable beam steerable at fixed frequency, subwavelength (0.2 λg × 0.2 λg) square-shaped patch that perturbed to stimulate circular polarization radiation. Moreover, single-voltage bias circuit, allows all...

Abstract In vivo simultaneous visualization of multiple biomarkers is critical to accurately diagnose disease and decipher fundamental processes at a certain pathological evolution, which however rarely exploited. Herein, multimodal activatable imaging probe (P‐ 125 I) reported with fluoro‐photoacoustic radioactive signal for in (i.e., hepsin prostate‐specific membrane antigen (PSMA)) associated prostate cancer diagnosis prognosis. P‐ I contains near‐infrared (NIR) dye that caged...

view Abstract Citations (115) References (71) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS The Accretion Disk Limit Cycle Instability in Black Hole X-Ray Binaries Cannizzo, John K. ; Chen, Wan Livio, Mario We investigate the operation of limit cycle mechanism accretion disks around ∼10 Msun black holes. explore a regime parameter space relevant to these systems, and delineate range possible behaviors by testing response our one-dimensional, time-dependent,...

We report the discovery of strong aperiodic X-ray variability and quasi-periodic oscillation (QPO) in light curves a new nova, XTE J1550-564, evolution observed temporal properties during rise recent outburst. The power spectral analysis first observation reveals source (~28%) as well presence QPO at ~82 mHz with fractional rms amplitude ~14% over 2-60 keV energy range. Also apparent is harmonic ~9%. As flux increases, tends to become less variable, frequency increases rapidly, from 82 4 Hz,...