A5100711534- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Immune Cell Function and Interaction
- Micro and Nano Robotics
- Pluripotent Stem Cells Research
- nanoparticles nucleation surface interactions
- Digital Imaging for Blood Diseases
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Children's Physical and Motor Development
- Reproductive Biology and Fertility
- RNA Interference and Gene Delivery
- Heat Transfer and Optimization
- Motor Control and Adaptation
- Blood properties and coagulation
- Seed Germination and Physiology
- Advanced Thermodynamics and Statistical Mechanics
- Muscle activation and electromyography studies
- Sperm and Testicular Function
Xi'an Jiaotong University
2022-2025
The Ohio State University
2014-2021
Massachusetts General Hospital
2017-2018
Shriners Hospitals for Children - Boston
2017-2018
Harvard University
2017-2018
Shriners Hospitals for Children
2017
In-Q-Tel
2014
Lung Institute
2014
École Normale Supérieure - PSL
2006
Northwestern University
1998
Supercooling of aqueous solutions below their melting point without any crystallization is a fundamentally and practically important physical phenomenon with numerous applications in biopreservation beyond. Under normal conditions, heterogeneous nucleation mechanisms critically prohibit the simultaneous long-term (> 1 week), large volume ml) low temperatures (< -10 oC) supercooling solutions. Here, order to overcome this bottleneck enable novel practical applications, we report on use...
A novel coaxial electrospray technology is developed to generate microcapsules with a hydrogel shell of alginate and an aqueous liquid core living cells using two fluids in one step. Approximately 50 murine embryonic stem (ES) encapsulated the high viability (92.3 ± 2.9%) can proliferate form single ES cell aggregate 128.9 17.4 μm each microcapsule within 7 days. Quantitative analyses gene protein expression indicate that cultured miniaturized 3D core-shell have significantly higher...
Abstract Massage RNA (mRNA) vaccines represent a new strategy for advanced cancer immunotherapy. To protect mRNA from degradation and deliver to targeted cells, lipid nanoparticles (LNPs) are extensively utilized as non‐viral vectors. However, the stability of mRNA‐laden LNPs substantially hinders their clinical application. Development thermostable durable nanovaccines is urgently needed. Here, hyaluronan dynamic hydrogel reported resiquimod (R848)‐laden (HA‐mRLNPs) at room temperature A...
<title>Abstract</title> Extending the shelf life of red blood cells (RBCs) is vital for transfusion medicine, yet traditional storage methods like refrigeration and cryopreservation suffer from limitations such as lesions ice-induced damage. We developed an improved supercooling preservation system large-volume (100 ml) RBC suspensions in commercial polyvinylchloride (PVC) bags by minimizing favorable sites ice nucleation maintaining precise thermal control at − 8°C. This engineered protocol...
Fluid displacement during droplet formation at microfluidic flow-focusing junctions was revealed and controlled to generate hydrogel microparticles of various morphologies.
Microfluidics involving two immiscible fluids (oil and water) has been increasingly used to produce hydrogel microparticles with wide applications. However, it is difficult extract the out of microfluidic Stokes flows oil that have a Reynolds number (the ratio inertia viscous force) much less than one, where dominant force tends drive move together surrounding oil. Here, we present passive method for extracting in flow from into aqueous solution on-chip by utilizing intrinsic interfacial...
A dielectrophoresis (DEP)-based method achieves highly efficient on-chip extraction of cell-laden microcapsules any stiffness from oil into aqueous solution. The hydrogel can be extracted the solution by DEP and interfacial tension forces with no trapped oil, while encapsulated cells are free electrical damage due to Faraday cage effect.
The direction of rotation (DOR) individual elbow muscles, defined as the in which a muscle rotates forearm relative to upper arm three-dimensional space, was studied vivo function flexion and rotation. Electrical stimulation used activate an selectively, resultant flexion-extension, supination-pronation, varus-valgus moments were determine DOR. Furthermore, multi-axis moment-angle relationships muscles determined by stimulating at constant submaximal level across different joint positions,...
Directed neural differentiation of embryonic stem cells (ESCs) has been studied extensively to improve the treatment neurodegenerative disorders. This can be done through stromal-cell derived inducing activity (SDIA), by culturing ESCs directly on top a layer feeder stromal cells. However, usually become mixed with during process, making it difficult obtain pure population differentiated for further use. To address this issue, non-planar microfluidic device is used here encapsulate murine...