A5055199397- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- melanin and skin pigmentation
- Fusion materials and technologies
- Erythrocyte Function and Pathophysiology
- Ophthalmology and Visual Impairment Studies
- Advanced ceramic materials synthesis
- SARS-CoV-2 detection and testing
- Bacteriophages and microbial interactions
- Corneal surgery and disorders
- Carbohydrate Chemistry and Synthesis
- Vibrio bacteria research studies
- Diabetes Treatment and Management
- Biochemical and Structural Characterization
- High-pressure geophysics and materials
- Pneumocystis jirovecii pneumonia detection and treatment
- Garlic and Onion Studies
- Glaucoma and retinal disorders
- Chemical Reactions and Isotopes
- NF-κB Signaling Pathways
- Magnolia and Illicium research
- Ginseng Biological Effects and Applications
- Lichen and fungal ecology
- Phytochemical Studies and Bioactivities
Army Medical University
2006-2025
Southwest Medical University
2024
Shandong University
2011-2023
University of Plymouth
2023
National University of Singapore
2023
Chengdu University of Traditional Chinese Medicine
2022
Shandong Provincial QianFoShan Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Southwest Petroleum University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2021
<title>Abstract</title> Extending the shelf life of red blood cells (RBCs) is vital for transfusion medicine, yet traditional storage methods like refrigeration and cryopreservation suffer from limitations such as lesions ice-induced damage. We developed an improved supercooling preservation system large-volume (100 ml) RBC suspensions in commercial polyvinylchloride (PVC) bags by minimizing favorable sites ice nucleation maintaining precise thermal control at − 8°C. This engineered protocol...
The transcription factor zinc-finger protein Miz1 represses TNF-α–induced JNK activation and the repression is relieved upon TNF-α stimulation. However, underlying mechanism incompletely understood. Here we report that interferes with ubiquitin conjugating enzyme (E2) Ubc13 for binding to RING domain of TNF-receptor associated 2 (TRAF2), thereby inhibiting ligase (E3) activity TRAF2 suppressing activation. Upon stimulation, rapidly undergoes K48-linked polyubiquitination at Lys388 Lys472...
To evaluate the repeatability of Corvis ST corneal biomechanical, tonometry and pachymetry measurements, agreement measures with Pentacam HR RTVue OCT. Three consecutive measurements right eye 238 myopic subjects were acquired ST, HR, Repeatability was evaluated by within-subject standard deviation [Sw] limit [r]. The central thickness (CCT) compared among three instruments using Bland-Altman limits agreement. Comparisons further stratified CCT (Corneathin ≤ 500 µm; Corneanormal = 500-550...
A high-quality X-ray crystal structure reveals the mechanism of compound <bold>1a</bold> inhibiting SIRT2 deacetylase and decanoylase.
The development of an efficient manufacturing process for sotagliflozin (LX4211), a dual inhibitor sodium–glucose cotransporter-1/2 (SGLT-1/2) the treatment diabetes, is described. Sotagliflozin features five contiguous chiral centers on carbohydrate core flanked by thioether group and biaryl moiety. Three are obtained from starting material l-xylose, while other two were established (or modified) via three highly stereoselective transformations: Luche reduction (dr: 97/3), dynamic kinetic...
Two process routes for LX1031, a tryptophan hydroxylase inhibitor the treatment of irritable bowel syndrome, were developed. They shared same left-hand and right-hand starting materials as well penultimate intermediate. The chiral center in moiety was established via Noyori asymmetric hydrogenation trifluoromethyl aryl ketone. boronate prepared palladium-catalyzed borylation l-tyrosine-derived triflate. Union these two fragments to pyrimidine core, from right- or side, constituted first-...
The emergence and spread of metallo-β-lactamase (MBL)-mediated resistance to β-lactam antibacterials has already threatened the global public health. A clinically useful MBL inhibitor that can reverse not been established yet. We here report a series [1,2,4]triazole derivatives analogs, which displayed inhibition relevant subclass B1 (Verona integron-encoded MBL-2) VIM-2. 3-(4-Bromophenyl)-6,7-dihydro-5H-[1,2,4]triazolo [3,4-b][1,3]thiazine (5l) manifested most potent with an IC50...
3R,3′R)-2,2′,3,3′-tetrahydroneoprzewaquinone A (1), a previously undescribed neoprzewaquinone analogue, was isolated from the root of Salvia miltiorrhiza Bunge.Its absolute configuration elucidated by comprehensive analyses spectra including NMR and MS combined with ECD calculations.MTT assay indicated that 1 can inhibit proliferation MV-4-11, TMD-8, MOLM-13, H460 cell lines IC50 values 2.21 μM, 2.48 3.39 2.02 μM respectively.
A practical synthesis of 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a key intermediate in the preparation new class potent deoxycytidine kinase (dCK) inhibitors, is described. The commercially available 2,4-dichloro-5-fluoropyrimidine (12) converted four telescoped steps to tert-butyl 4-(4-amino-5-fluoropyrimidin-2-yloxy)piperidine-1-carboxylate (6a) which upon deprotection gives 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine dihydrochloride (1a) about 68% overall yield. This process...
Hermansky–Pudlak syndrome (HPS) is an autosomal recessive disorder in humans and mice. Pale ear (ep) pearl (pe) mice, bearing mutations the biogenesis of lysosomal organelles complex 3 subunit 1 (Hps1) adaptor-related protein 3, beta (Ap3b1) genes respectively, are mouse models human HPS Type (HPS1) 2 (HPS2) respectively. In present study we investigated compared reduced fertilities ep pe male Both males exhibited lower abilities to impregnate C57BL/6J (B6) females, B6 females mated with...
A harmonious interspecies relationship is the key to success of mixed afforestation. This study was conducted assess responses afforestation species their neighboring trees. We examined five types stands—monocultures Chinese pine ( Pinus tabuliformis ), black locust Robinia pseudoacacia sea‐buckthorn Hippophae rhamnoides and two mixtures (Chinese × mixture mixture)—in Loess Plateau, northwestern China. The height diameter at breast each tree were measured, rhizosphere soil, shoot, root...
Tungsten and its alloys are considered to be the most nominated plasma-facing materials in fusion reactors, which will exposed enormously rigorous conditions such as thermal load, plasma exposure, neutron radiation. At present, research on behavior of oxide particle-reinforced tungsten-based under long-term steady-state heat load transient shock is insufficient. The purpose this study investigate performance yttria tungsten plates prepared by wet chemical method loads means indirect coupling...
High performance rigid polyurethane foam (RPUF) has been designed by using hyperbranched (HBPU) polyol with high functionality to replace traditional polyol. The influences of different types on the apparent density and heat deformation temperature RPUF were studied. microstructures, including cell structure, diameter distribution, characterised SEM. Effects structure discussed. Thermal resistance thermal stability measured vicat meter TGA. conductivity was Hot Disk, mechanical properties...