A5022607212- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Chronic Myeloid Leukemia Treatments
- Folate and B Vitamins Research
- Drug Transport and Resistance Mechanisms
- Bipolar Disorder and Treatment
- Bone Metabolism and Diseases
- GDF15 and Related Biomarkers
- T-cell and Retrovirus Studies
- Cancer-related gene regulation
Beijing Shijitan Hospital
2017-2025
Capital Medical University
2017-2025
China International Science and Technology Cooperation
2022
Tang Du Hospital
2019
Air Force Medical University
2019
Solute carrier (SLC) transporters play a crucial role in facilitating the cellular uptake of various anticancer drugs, such as methotrexate (MTX). This study aimed to analyze impact nonsynonymous single nucleotide polymorphisms (SNPs)
Abstract Background The pharmacokinetics and therapeutic response to methotrexate (MTX) display large variability in the treatment of acute lymphoblastic leukemia (ALL). aim present study was investigate association two microRNA (miRNA) binding site polymorphisms (rs3737966 G > A rs35134728 DEL/TTC) 3′‐untranslated region MTHFR with serum MTX concentrations, a Chinese pediatric population ALL. Methods Genotyping for rs3737966 144 children ALL performed using Sequenom MassArray system...
It is known that γ-glutamyl hydrolase (GGH) involved in the disposition of methotrexate (MTX), and GGH activity regulated by DNA methylation acute lymphoblastic leukemia (ALL) cells. The present study explores status promoter peripheral blood its association with MTX levels toxicities Chinese children ALL.Serum concentrations were determined fluorescence polarization immunoassay. Methylation quantification genotyping for rs3758149 rs11545078 was performed Sequenom MassARRAY 50 pediatric...
Abstract Study Objective The objective of the present study was to examine frequency distribution five single‐nucleotide polymorphisms (SNPs; rs1801394 A>G, rs1532268 C>T, rs162036 rs10380 and rs9332 C>T) methionine synthase reductase (MTRR) gene, their effects on methotrexate (MTX) concentration, risk relapse in a Chinese pediatric population with acute lymphoblastic leukemia (ALL). Design This retrospective single‐center study, all analyses were exploratory. Setting Pediatric...
Thymidylate synthase (TYMS) is an important target for methotrexate (MTX). Genetic variations in the TYMS gene contribute to differences treatment responses MTX. The aim of this study was investigate distribution a microRNA (miRNA) binding site polymorphism (rs2790 A > G) 3'-untranslated region (3'-UTR) and its association with MTX concentration haematological toxicity Chinese paediatric patients acute lymphoblastic leukaemia (ALL).The Sequenom MassARRAY system used rs2790 G genotyping 118...
What is known and objective Reduced folate carrier 1 (RFC1), which encoded by the human solute family 19 member (SLC19A1) gene, plays an essential role in cellular uptake of methotrexate (MTX). RFC1 expression regulated genetic variations epigenetic modifications. The aim present study was to investigate methylation status SLC19A1 promoter peripheral blood its association with MTX levels toxicities children acute lymphoblastic leukaemia (ALL). Methods Serum concentrations were measured using...