A5063315923- Chronic Kidney Disease and Diabetes
- Gastric Cancer Management and Outcomes
- Animal Virus Infections Studies
- Metastasis and carcinoma case studies
- Dialysis and Renal Disease Management
- Advanced Sensor and Energy Harvesting Materials
- Systemic Lupus Erythematosus Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Dielectric materials and actuators
- Gestational Diabetes Research and Management
- Essential Oils and Antimicrobial Activity
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Neurobiology and Insect Physiology Research
- Nanoplatforms for cancer theranostics
- Glutathione Transferases and Polymorphisms
- Pregnancy-related medical research
- Pancreatitis Pathology and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Psoriasis: Treatment and Pathogenesis
Chinese Academy of Sciences
2023-2025
Hebei Medical University
2013-2025
Fourth Hospital of Hebei Medical University
2015-2025
Nanjing Agricultural University
2024-2025
Ningbo Institute of Industrial Technology
2024-2025
Zhejiang Cancer Hospital
2022-2024
Wenzhou Medical University
2011-2024
Sun Yat-sen University
2013-2024
University of Chinese Academy of Sciences
2022-2024
Guangdong Medical College
2015-2024
Abstract Background The investigational use of zolbetuximab (IMAB362), a groundbreaking monoclonal antibody medication targeting claudin 18.2 (CLDN18.2), for treatment advanced gastrointestinal cancers is currently underway. unclear clinicopathological characteristics and tumour immune microenvironment CLDN18.2-positive gastric cancer (GC) make it difficult to develop optimize CLDN18.2-targeted therapies. Methods A total 451 tissues, 342 matched paraneoplastic 107 metastatic lymph nodes were...
Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized novel glucose-modified QU liposome (QU–Glu–Lip), aiming not only to overcome QU’s poor water solubility bioavailability but also deliver more brain tissue enhance its neuroprotective effect. QU–Glu–Lip possessed encapsulation efficiency (EE) of 89.9%, homogenous...
Abstract The exchange bias (EB) effect plays an undisputed role in the state‐of‐art spintronic devices, both rigid and flexible. However, poor stability of EB under mechanical strain is detrimental to construction reliable flexible which poses a great challenge for potential wearable applications. Here, it revealed that strain‐induced variation field can be greatly suppressed by engineering IrMn/[Co/Pt] 3 systems featured with perpendicular magnetic anisotropy (PMA). Particularly,...
Flexible magnetic sensors, which have advantages such as deformability, vector field sensing, and noncontact detection, are an important branch of flexible electronics significant applications in fields magnetosensitive electronic skin. Human skin surfaces complicated deformations, pose a demand for sensors that can withstand omnidirectional strain while maintaining stable performance. However, existing sensor arrays only stretching along specific directions prone to failure under...
ABSTRACT Classical swine fever virus (CSFV) incurs substantial economic losses in the global industry due to its persistent emergence and re-emergence across various countries. However, precise mechanisms governing CSFV budding remain inadequately understood. Our study elucidates that endosomal sorting complex required for transport (ESCRT)-associated protein ALIX, conjunction with ESCRT-III, plays a pivotal role orchestrating budding. Genomic sequence analysis identified critical...
Problem To evaluate the effects of anti‐inflammatory and anti‐angiogenic roles LXA4 on endometriosis in mice. Method study Endometriosis was induced 40 mice separated into two groups. group administered by for 3 weeks. The endometriotic lesions were counted, measured, identified pathology. presence a panel pro‐inflammatory factors assessed real‐time RT ‐ PCR , enzyme‐linked immunoassay, m RNA protein levels matrix metalloproteinase ( MMP s), vascular endothelial growth factor VEGF )...
Abstract Objective This study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs). Methods A retrospective enrollment 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 December 31, 2021. The compared essential features survival rates. Additionally, prognosis carcinomas/mixed neuroendocrine–non‐neuroendocrine (g‐NEC/MiNEN) were contrasted those adenocarcinoma (GAC)...
Background We sought to develop a new equation estimate glomerular filtration rate (GFR) in Chinese elderly population. Methods A total of 668 participants, including the development cohort (n = 433), validation 235) were enrolled. The using generalized additive model, and age, gender, serum creatinine as predictor variables was developed performances compared with CKD-EPI equation. Results In data set, both bias precision improved equation, (median difference, −1.5 ml/min/1.73 m2 vs. 7.4...
An accurate evaluation of cognitive function, physical health, and psychological health is fundamental for assessing problems in the elderly population, it important to identify necessity early therapeutic intervention. The objective this study was evaluate states mental functions investigate relationships between sociodemographic features these a community-dwelling population.This community-based cross-sectional conducted suburban district Shanghai, China. A total 1025 participants aged...
Objective To improve the performance of glomerular filtration rate (GFR) estimating equation in Chinese type 2 diabetic patients by modification CKD-EPI equation. Design and A total 1196 subjects were enrolled. Measured GFR was calibrated to dual plasma sample 99mTc-DTPA-GFR. GFRs estimated re-expressed 4-variable MDRD equation, Asian modified compared 351 diabetic/non-diabetic pairs. And a new reconstructed 589 patients. Results In terms both precision accuracy, equations all achieved...
ABSTRACT Mitochondria are energy producers in cells, which can affect viral replication by regulating the host innate immune signaling pathways, and changes their biological functions inextricably linked life cycle. In this study, we screened a library of 382 mitochondria-targeted compounds identified antiviral inhibitors dihydroorotate dehydrogenase (DHODH), rate-limiting enzyme de novo synthesis pathway pyrimidine ribonucleotides, against classical swine fever virus (CSFV). Our data showed...