A5102796814- Tea Polyphenols and Effects
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Alzheimer's disease research and treatments
- Helicobacter pylori-related gastroenterology studies
- Cutaneous lymphoproliferative disorders research
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Ginkgo biloba and Cashew Applications
- Anesthesia and Neurotoxicity Research
- Cytomegalovirus and herpesvirus research
- Eosinophilic Esophagitis
- Food Quality and Safety Studies
- Gastroesophageal reflux and treatments
- Ferroptosis and cancer prognosis
- Acupuncture Treatment Research Studies
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Acute Kidney Injury Research
- Membrane-based Ion Separation Techniques
- Cancer Mechanisms and Therapy
- Mesenchymal stem cell research
- Proteins in Food Systems
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Institute of Hematology & Blood Diseases Hospital
2024-2025
Xuzhou Medical College
2024
Sichuan Academy of Agricultural Sciences
2022-2024
Institute of Agro-Products Processing Science and Technology
2022-2024
Wuhan Third Hospital
2019-2024
Nanjing Traditional Chinese Medicine Hospital
2024
Changzhou No.2 People's Hospital
2023-2024
Xuzhou No.1 People's Hospital
2024
Tongren Hospital
2019-2023
Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized novel glucose-modified QU liposome (QU–Glu–Lip), aiming not only to overcome QU’s poor water solubility bioavailability but also deliver more brain tissue enhance its neuroprotective effect. QU–Glu–Lip possessed encapsulation efficiency (EE) of 89.9%, homogenous...
Introduction Lung adenocarcinoma (LUAD) is a prevalent form of lung cancer originating from glandular cells with low survival rates despite recent therapeutic advances due to its diverse and complex nature. Recent evidence suggests link between ferroptosis the effectiveness anti-PD-L1 therapy, potential synergistic effects. Methods Our study comprehensively analyzed expression patterns regulators in LUAD their association prognosis PD-L1 expression. Furthermore, we identified two distinct...
Abstract The effect of TP53 alterations on childhood B‐cell acute lymphoblastic leukemia (B‐ALL) remains unclear. To investigate the prognostic value deletion ( del ) and mutation mut ), this post hoc study used fluorescence in situ hybridization test to detect 907 newly diagnosed B‐ALL patients from a prospective cohort Chinese Children's Cancer Group ALL‐2015 trial. Targeted gene sequencing was identify 342 out patients. detected 4.4% frequency hypodiploidy higher subgroup (7.5% vs. 0.5%,...
Objectives. Our previous study has used RNA-seq technology to show that apoptotic molecules were involved in the myocardial protection of electroacupuncture pretreatment (EAP) on ischemia/reperfusion (I/R) animal model. Therefore, this was designed investigate how EAP protects myocardium against I/R injury through antiapoptotic mechanism. Methods. By using rats with I/R, we ligated left anterior descending artery (LAD) for 30 minutes followed by 4 hr reperfusion after at Neiguan (PC6)...
Verubecestat is a potent BACE1 enzyme inhibitor currently being investigated in Phase III trials for the treatment of mild-to-moderate and prodromal Alzheimer's disease. Multiple anti-amyloid immunotherapies have been dose-limited by adverse amyloid related imaging abnormalities such as vasogenic edema (ARIA-E) microhemorrhage (ARIA-H) observed human mice. was tested 12-week nonclinical study potential to exacerbate profiles 18-22-month-old post-plaque Tg2576-AβPPswe Animals were treated...
Symptoms of refractory gastroesophageal reflux disease (GERD) are commonly encountered in clinical practice. The aim this study was to analyze the data obtained from questionnaires, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring patients with persisting GERD symptoms explore possible underlying causes for presentation. After completing selected underwent endoscopy, HRM, monitoring. Based on results these investigations, we divided into 4 groups: esophagitis (RE),...
Optimal treatment options for post‑infectious bronchiolitis obliterans (PIBO) have not yet been established. The present study retrospectively analyzed the effect of budesonide, montelukast and azithromycin on treating PIBO in children <5 years old.. Based regimen, cohort was divided into group A B. Group received a combination at least 3 months B unconventional (budesonide nebulization intermittently, prednisone, antibiotics if necessary) compared with standard treatment. Tidal pulmonary...
Constipation, a widespread gastrointestinal disorder, often leads to the exploration of natural remedies. This study examines efficacy Golden Flower Tibetan Tea Polysaccharides (GFTTPs) in alleviating constipation mice. Chemical analyses reveal that GFTTPs possess O-H, carboxyl, carboxylic acid (-COOH), and C-O-C groups, alongside porous crystal structure with thermal stability. In animal experiments, significantly upregulated aquaporin 3 (AQP3) 8 (AQP8) expressions colon, enhancing water...
(-)-Epigallocatechin-3-gallate (EGCG) possesses potent antioxidant and neuroprotective properties. In this study, a novel glucose-modified EGCG encapsulated liposome (EGCG-Glu-Lip) was developed characterized. EGCG-Glu-Lip liposome's cytotoxicity, brain targeting ability, its antioxidative neuroprotection were examined via bEnd.3 PC12 cells testing. particle mean size 158.7 nm, with encapsulation efficiency 73.05 % under EGCG/lipid mass ratio 1:22 soybean phospholipids (SPC) to cholesterol...
Substantial evidence implicates Aß peptides in the etiology of Alzheimer's disease (AD). is produced by proteolytic cleavage amyloid precursor protein b - and g -secretase enzymes. Thus, (BACE1) inhibition a promising modifying treatment for AD. Utilizing transgenic CRND8 (TgCRND8) mice, model AD-related accumulation deposition, we assessed effects 11 weeks chronic, diet, oral administration potent selective small molecule iminoheterocycle BACE inhibitor on amyloid-related pathology when...
Highly Active Antiretroviral therapy (HAART) can effectively reduce the viral load to undetectable levels in most HIV-infected patients. However, some patients may still experience impaired immunologic response associated with increased risk of disease progression and death.The objective this study was assess impact HIV DNA on immune alteration during successful HAART.40 chronic adults initiating HAART were followed for 24 months. The CD4 count, load, γ-cytokines IL-2, IL-7 IL-21 monitored...
To investigate the effect of neutrophil gelatinase-associated lipocalin (NGAL) on prognosis patients with type 2 hepatorenal syndrome (HRS).A total 54 HRS were included in study, and stratified for analysis according to survival status at 6-month followup:survival group, n=25; death n=29. Single factor was used compare betweengroup differences levels plasma NGAL, urine renin, aldosterone, blood biochemical indicators. The Cox proportional hazard regression model assess HRS. F-test, t-test,...
<title>Abstract</title> Background Protein phosphatase 2A (PP2A) plays a critical and multifaceted role in numerous physiological processes. Previously, we generated germ cell specific knockout mice for the PP2A catalytic subunit alpha (Ppp2ca<sup>cKO</sup>) by cre-loxp system. Methods results Through high-throughput miRNA sequencing of testis tissues real‑time PCR, identified significant decrease expression miR-138-5p testes Ppp2ca<sup>cKO</sup> mice. Here, report that affects apoptosis...
<title>Abstract</title> The effect of <italic>TP53</italic> alterations on childhood B-cell acute lymphoblastic leukemia (B-ALL) remains unclear. To investigate the impact deletion (<italic>TP53</italic><sup><italic>del</italic></sup>) and TP53 mutation (<italic>TP53</italic><sup><italic>mut</italic></sup>) prognosis, this post-hoc study used fluorescence in situ hybridization test to detect <italic>TP53</italic><sup><italic>del</italic></sup> 914 newly diagnosed B-ALL children from a...
Rectal mucosal melanoma is a rare and highly aggressive disease. Common symptoms include anal pain, an mass, or bleeding. As such, the disease usually detected on rectal examination of patients with other suspected anorectal diseases. However, due to its rarity nonspecific symptoms, mucosa easily misdiagnosed.
Immunity reconstitution (IR) is crucial for pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), but the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on lymphocyte subsets post-transplant remains unclear. Therefore, we assessed immune dynamics in children after SARS-CoV-2 infection.