A5100583455- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Radiomics and Machine Learning in Medical Imaging
- HER2/EGFR in Cancer Research
- Autophagy in Disease and Therapy
- Autoimmune and Inflammatory Disorders Research
- Cancer Cells and Metastasis
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2023-2024
Wenzhou Medical University
2024
Zhejiang Cancer Hospital
2024
Abstract Background Programmed cell death protein 1 (PD-1) checkpoint inhibitors such as pembrolizumab are novel therapeutics used to treat various advanced malignancies. Immune-related adverse events common, among the most serious of these toxicities is hemophagocytic lymphohistiocytosis (HLH), which a life-threatening disorder unbridled immune activation but has not been properly established. Methods We have procured first case an aftermath treatment with from Sir Run Shaw Hospital,...
Abstract In the 8th edition of American Joint Committee on Cancer (AJCC) staging system for Non-Small Cell Lung (NSCLC), tumors exhibiting main bronchial infiltration (MBI) near carina and those presenting with complete lung obstructive pneumonia/atelectasis (P/ATL) have been reclassified from T3 to T2. Our investigation into Surveillance, Epidemiology, End Results (SEER) database, spanning 2007 2015 adjusted via Propensity Score Matching (PSM) additional variables, disclosed a notably...
In individuals receiving treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), those exhibiting positive PD-L1 expression might experience reduced progression-free survival (PFS). However, the effects on overall (OS) and determination of efficacious approaches are still not well-defined.
Abstract Background: In individuals receiving treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), those exhibiting positive PD-L1 expression might experience reduced progression-free survival (PFS). However, the effects on overall (OS) and determination of efficacious approaches are still not well-defined. Methods: our retrospective study, we examined data from 201 NSCLC patients advanced EGFR mutations, treated at two centers Shaw Hospital in Zhejiang,...
Abstract Disulfidptosis represents a novel cell death mechanism triggered by disulfide stress, with potential implications for advancements in cancer treatments. Although emerging evidence highlights the critical regulatory roles of long non-coding RNAs (lncRNAs) pathobiology lung adenocarcinoma (LUAD), research into lncRNAs specifically associated disulfidptosis LUAD, termed disulfidptosis-related (DRLs), remains insufficiently explored. Using The Cancer Genome Atlas (TCGA)-LUAD dataset, we...
<title>Abstract</title> Background Early-onset gastric cancer (EOGC, ≤ 45 years) exhibits distinct clinicopathological characteristics, and its incidence is rising. This study aims to offer insights into treatment strategies for patients across different age groups by retrospectively analyzing the features, distant metastasis patterns, prognostic factors of EOGC patients. Methods We performed a retrospective analysis data from 33,675 in Surveillance, Epidemiology, End Results database...
Neoadjuvant chemo-immunotherapy has increased the number of patients with advanced lung cancer eligible for surgery. However, only a small such respond to this approach. Intensive research is being conducted identify biomarkers predict efficacy neoadjuvant chemo-immunotherapy. Among these, blood predictive are particularly promising, and have advantages both non-invasive cost effective. This study aims evaluate value in determining non-small cell (NSCLC), addressing critical need more...
Background In non-small cell lung cancer (NSCLC), patients with extrathoracic metastases typically have a poor prognosis, systemic chemotherapy being the standard care. The full potential of primary resection therapy (PRT) in these patients, especially during immunotherapy era, is not fully established. Additionally, effectiveness preoperative this context unclear. Methods This retrospective study identified NSCLC from Surveillance, Epidemiology, and End Results (SEER) database 2010 to 2019....
Abstract Background Disulfidptosis, a recently discovered cellular death mechanism, has been proposed as potential target for cancer therapy. However, its relationship with Cervical Cancer (CC) remains largely unexplored. Our research primarily focuses on understanding the role of associated long non-coding RNA (lncRNA) in Disulfidptosis and implications immune response prognosis CC patients. Methods Using data from Genome Atlas (TCGA), Disulfidptosis-associated lncRNAs were identified risk...