A5101532865- Nuclear Receptors and Signaling
- Colorectal Cancer Treatments and Studies
- Electric Motor Design and Analysis
- Gear and Bearing Dynamics Analysis
- Neuroscience of respiration and sleep
- Macrophage Migration Inhibitory Factor
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Insect Utilization and Effects
- Multilevel Inverters and Converters
- Barrier Structure and Function Studies
- Helicobacter pylori-related gastroenterology studies
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Prostate Cancer Treatment and Research
- Tryptophan and brain disorders
- Advanced Measurement and Metrology Techniques
- Sensorless Control of Electric Motors
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Geoscience and Mining Technology
- Neurobiology and Insect Physiology Research
- Biochemical effects in animals
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2011-2024
Jinzhou Medical University
2021-2022
Tianjin Medical University Cancer Institute and Hospital
2019
Shenyang Jianzhu University
2018
Xiamen University
2018
Jiangsu University of Science and Technology
2017
Affiliated Hospital of Qingdao University
2015-2016
Qingdao University
2015-2016
Abstract Background Programmed cell death protein 1 (PD-1) checkpoint inhibitors such as pembrolizumab are novel therapeutics used to treat various advanced malignancies. Immune-related adverse events common, among the most serious of these toxicities is hemophagocytic lymphohistiocytosis (HLH), which a life-threatening disorder unbridled immune activation but has not been properly established. Methods We have procured first case an aftermath treatment with from Sir Run Shaw Hospital,...
The critical roles of lncRNAs in drug resistance malignancies have been widely recognized. This investigation aims to study the function lncRNA PCAT6 non-small cell lung cancer (NSCLC) gefitinib. In our study, we demonstrated that prostate cancer-associated transcript 6 (PCAT6) was upregulated gefitinib-resistant NSCLC. knockdown inhibited gefitinib NSCLC, as indicated by decreased IC50 value, proliferation, and metastasis, increased apoptosis. Besides, could directly target miR-326 NSCLC...
391 Background: Claudin18.2 (CLDN18.2) is normally confined in tight junction of the gastric mucosa, but also often expressed several cancer types. AB011 a humanized, anti-CLDN18.2 monoclonal antibody (IgG1), which has shown impressive therapeutic synergy between and cytotoxic agents preclinical research. Here we report preliminary data on both as monotherapy combined with CAPOX patients advanced solid tumors (AB011-ST-01, NCT04400383). Methods: The primary objectives were to evaluate safety...
Background: This study investigated the prognostic value of inflammation-based scores in patients with high-risk localized prostate cancer who underwent radical prostatectomy or without neoadjuvant androgen deprivation therapy (ADT). Methods: Inflammation-based included neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte (PLR), nutritional index (PNI), and plasma fibrinogen. A total 440 (380 treated ADT 60 ADT) were retrospectively evaluated our medical center....
Classic opioid receptors, mu (μ), delta (δ), and kappa (κ), have been reported to be expressed in non-small cell lung cancer (NSCLC) lines tumor tissues play a role prognosis. However, the expression of non-classic receptor, nociceptin receptor (NOP) are unclear. Our hypothesis was that NOP also highly NSCLC this could correlated with patients' prognostic characters. Expression examined archived from 129 enrolled patients by immunohistochemistry further analyzed outcomes. detected. The...
402 Background: Immune checkpoint inhibitor monotherapy has limited efficacy in patients (pts) with previously treated advanced gastric cancer (GC). LAG-3 is upregulated GC pts and therefore treatment targeting may be effective. Tebotelimab a first-in-class, Fc-bearing bispecific tetravalent DART molecule that can bind both PD-1 LAG-3. Meanwhile, synergistic antitumor activities of tebotelimab niraparib, poly (ADP-ribose) polymerase inhibitor, were demonstrated preclinical studies. Methods:...
The traditional transfer matrix method used to calculate the critical speed of high-speed spindle motor rotor system will produce large errors. Taking 170SD30 electrospindle as analysis object, a electric dynamics theoretical model was established based on Riccati method, using Matlab program and kinetic parameters first three speeds natural frequencies spindle. Finally, simulation data compared with experimental data. results show that is 2.3% more accurate than it verifies accuracy...
To explore the protective effects of Danhong injection against cerebral damage during on-pump coronary artery bypass graft surgery and its mechanism. Methods . Fifty patients scheduled for CABG were randomly divided into group (group D) control C). Group D was given while C same volume normal saline when cut open. Jugular bulb blood right before operation began (T1), body temperature rewarming to 36°C (T2), 30 min after termination cardiopulmonary (T3), 6 hrs CPB (T4) collected. The...
Docetaxel-associated liver injury has become a serious public health problem, resulting in therapy discontinuation, failure, and death. Zafirlukast is typical leukotriene receptor antagonist used for prophylaxis chronic treatment of asthma. In this study, we investigate whether with could alleviate Docetaxel-induced cytotoxicity hepatocytes. Our results indicate that mitigated toxicity LO-2 Firstly, reduced the production 8-hydroxy-2p-deoxyguanosine (8-OHdG) increased levels glutathione...
Epidermal growth factor receptor (EGFR) is a well-known target for cancer treatment. However, the authorized anti-EGFR monoclonal antibodies generally cause several toxic effects, especially severe cutaneous toxicities as well infusion reactions, and clinical indications are limited. Here we developed Ametumumab, fully human recombinant antibody.To assess safety, tolerability, pharmacokinetics (PK), immunogenicity of Ametumumab.A first-in-human phase Ia dose escalation study Ametumumab in...