A5101609784- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Radiation Therapy and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Fluorine in Organic Chemistry
- Cancer, Hypoxia, and Metabolism
- GaN-based semiconductor devices and materials
- Click Chemistry and Applications
- Medical Imaging Techniques and Applications
- Synthesis and Reactions of Organic Compounds
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Biliary and Gastrointestinal Fistulas
- IgG4-Related and Inflammatory Diseases
- Aortic aneurysm repair treatments
China University of Petroleum, Beijing
2025
University of Oxford
2021-2025
Southern Medical University
2023-2024
Xiamen University
2004-2024
Tongji Hospital
2024
Shandong University
2023
Shanghai Jiao Tong University
2023
Renji Hospital
2023
Air Force Medical University
2023
Guangxi Medical University
2019-2022
Stabilization and increased activity of hypoxia-inducible factor 1-α (HIF-1α) can directly increase cancellous bone formation play an essential role in modeling remodeling. However, whether HIF-1α expression adipose-derived stem cells (ADSCs) increases osteogenic capacity promotes regeneration is not known.In this study, ADSCs transfected with small interfering RNA overexpression plasmid were established to investigate the proliferation, migration, adhesion, angiogenic ability human...
Poly(adenosine diphosphate ribose) polymerase (PARP) has emerged as an effective therapeutic strategy against cancer that targets the DNA damage repair enzyme. PARP-targeting compounds radiolabeled with Auger electron–emitting radionuclide can be trapped close to damaged in tumor tissue, where high ionizing potential and short range lead electrons kill cells through creation of complex damage, minimal surrounding normal tissue. Here, we report on [<sup>123</sup>I]CC1, <sup>123</sup>I-labeled...
Background: Axillary lymph nodes (ALN) status serves as a crucial prognostic indicator in breast cancer (BC). The aim of this study was to construct radiogenomic multimodal model, based on machine learning and whole-transcriptome sequencing (WTS), accurately evaluate the risk ALN metastasis (ALNM), drug therapeutic response avoid unnecessary axillary surgery BC patients. Methods: In study, conducted retrospective analysis 1078 patients from Cancer Genome Atlas (TCGA), Imaging Archive (TCIA),...
Pyridinic-N, pyrrolic-N, and graphitic-N fully exploit their distinct roles, amplify collective influence maximize the synergistic interaction between Pt NC, ultimately leading to exceptional HER performance over a broad pH range.
Abstract Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent, bioaccumulative anthropogenic pollutants that have attracted the attention of public private sectors because their adverse impact on human health 1 . Although various technologies been deployed to degrade PFASs with a focus non-polymeric functionalized compounds (perfluorooctanoic acid perfluorooctanesulfonic acid) 2–4 , general PFAS destruction method coupled fluorine recovery for upcycling is highly desirable....
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies access 18F-isotopologue of by applying a copper-mediated nucleophilic 18F-fluorodeboronation. most successful approach features an aldehydic boronic ester precursor that subjected reductive amination post-18F-labeling and affords [18F]rucaparib with activity yield 11% ± 3% (n = 3) molar (Am) up 30 GBq/μmol. Preliminary vitro studies are presented.
Abstract Purpose Rucaparib, an FDA-approved PARP inhibitor, is used as a single agent in maintenance therapy to provide promising treatment efficacy with acceptable safety profile various types of BRCA -mutated cancers. However, not all patients receive the same benefit from rucaparib-maintenance therapy. A predictive biomarker help patient selection for rucaparib and predict clinical therefore warranted. With this aim, we developed [ 18 F]rucaparib, F-labelled isotopologue rucaparib,...
Diseases caused by microorganisms can be controlled vaccines, which require neutralizing antigens. Therefore, it is very important to identify highly efficient immunogens for immune prevention. By combining immunoproteomics and bacterial challenge after immunization, we developed a rapid method screening protected antigens of pathogenic bacteria in aquaculture. Our approach may divided into three consecutive steps. First, dominant outer membrane proteins are screened immunoproteomics....
The controlled programming of regiochemical outcomes in nucleophilic fluorination reactions with alkali metal fluoride is a problem yet to be solved. Herein, two synergistic approaches exploiting hydrogen bonding catalysis are presented. First, we demonstrate that modulating the charge density hydrogen-bond donor urea catalyst directly influences kinetic regioselectivity dissymmetric aziridinium salts aryl and ester substituents. Moreover, report urea-catalyzed formal dyotropic...
Background: Hepatocellular carcinoma (HCC) has high morbidity and mortality lacks effective biomarkers for early diagnosis survival surveillance.Origin recognition complex (ORC), consisting of ORC1-6 isoforms, was examined to assess the potential significance ORC isoforms HCC prognosis.Methods: Oncomine Gene Expression Profiling Interactive Analysis (GEPIA) databases were used examine differential isoform expression, stage-specific calculate Pearson correlations perform analysis.A human...
Graphical Abstract Inhibition of PTEN simultaneously improved the anti-inflammatory effect and osteogenic capacity TADSCs, ultimately promoted peri-implant bone formation in T2DM rats.
Abstract Purpose Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous normal tissue. Hence, the injected mass, molar activity potential pharmacological effects important considerations use of radiolabelled inhibitors diagnostic radionuclide therapeutic applications. Here, we performed a systematic evaluation by varying [ 18 F]olaparib mass Total to investigate on...
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy with a rising incidence worldwide. The prognosis of HCC patients after radical resection remains poor. Radiomics novel machine learning method that extracts quantitative features from medical images and provides predictive information cancer, which can assist cancer diagnosis, therapeutic decision-making improvement.To develop validate contrast-enhanced computed tomography-based radiomics model for predicting overall...
Abstract Airy beam possesses a wide range of applications owing to its special properties non-diffraction, self-accelerating, and self-healing. However, conventional generators are not conducive their miniaturization or integration. In this paper, technique for generating is introduced with polarization conversion within the frequency 0.9–1.2 THz based on reflective vanadium dioxide (VO 2 ) metasurface. Our design composed VO elliptical patch, SiO spacer, gold substrate. When metallic...
Abstract Herein, we disclose that pyridinium salts derived from abundant (hetero)anilines represent a novel precursor class for nucleophilic aromatic substitution reactions with [ 18 F]fluoride. The value of this new F‐fluorodeamination is demonstrated the synthesis over 30 structurally diverse and complex heteroaryl F‐fluorides, several scaffolds were yet to be labelled fluorine‐18. protocol tolerates heteroarenes functionalities commonly found in drug discovery libraries, amenable scale‐up...
Abstract The purpose of this investigation was to explore the prognostic value phospholipase C delta (PLCD) genes in early stage pancreatic ductal adenocarcinoma (PDAC) and its potential molecular mechanisms. PLCD PDAC assessed using Kaplan‐Meier method multivariate Cox proportional hazards regression model. Genome‐wide correlation analysis performed on PLCD3 identify highly correlated transcriptome. Then, these together underwent a bioinformatics elucidate biological functions PDAC. PLCD1...
Backgrounds: Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide that difficult to diagnose during the early stages and its tumors are recurrent. Long non-coding RNAs (lncRNAs) have increasingly been associated with tumor biomarkers for diagnosis prognosis. This study attempts explore potential clinical significance of lncRNA DUXAP8 co-expression related protein coding genes (PCGs) HCC. Method: Data from total 370 HCC patients The Cancer Genome Atlas were utilized analysis. top...
The purpose of this study was to investigate the prognostic significance like-Sm (LSM) genes in early pancreatic ductal adenocarcinoma (PDAC) and explore potential molecular mechanism. protein product LSM1 gene is also known as CASM YJL124C, while that LSM4 GRP YER112W.Data from 112 patients attached Whipple surgery were collected TCGA database clinical characteristics survival data. Kaplan-Meier method multivariate Cox proportional risk regression model used analyze impact LSM on outcomes...
Objective The initial operation for type A aortic dissection has limitations, and there may be a need reoperation in cases such as giant pseudoaneurysm formation reduced blood supply to the distal vessels. In this study, we collected case data of patients who underwent cardiac major vascular surgery at our hospital analyze effectiveness treatment options summarize experience. Method Between June 2018 December 2022, 62 with (TAAD) after previous surgical treatment. Of these, 49 (45 males)...
Potassium channel Kv1.5 has been considered a key target for new treatments of atrial tachyarrhythmias, with few side effects. Four debromoaplysiatoxin analogues 6/6/12 fused ring system were isolated from marine cyanobacterium Lyngbya sp. Their planar structures elucidated by HRESIMS, 1D and 2D NMR. The absolute configuration oscillatoxin J (1) was determined single-crystal X-ray diffraction, the configurations K (2), L (3) M (4) confirmed on basis GIAO NMR shift calculation followed DP4...
The receptors neuropilin-1 (NRP-1) and integrin αvβ3 are overexpressed in breast cancer associated with neovascularization. We synthesized a heterodimeric tracer, 68Ga-DOTA-RGD-ATWLPPR, which simultaneously targets NRP-1 cancer. In this study, we evaluated the diagnostic efficacy of 68Ga-DOTA-RGD-ATWLPPR during micropositron emission tomography (microPET)/X-ray computed (CT) imaging gamma counting. receptor-binding characteristics tumor-targeting tracer vitro vivo. Static microPET/CT...