A5029867104- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant biochemistry and biosynthesis
- Breast Cancer Treatment Studies
- Steroid Chemistry and Biochemistry
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- Angiogenesis and VEGF in Cancer
- Transcranial Magnetic Stimulation Studies
- Mitochondrial Function and Pathology
- HER2/EGFR in Cancer Research
Affiliated Hospital of Youjiang Medical University for Nationalities
2020-2025
Xiangya Hospital Central South University
2021
Central South University
2021
Cuproptosis, a newly suggested mechanism of controlled cellular demise, which has been extensively associated with aspects occurrence and development in breast cancer. The aim this study was to conduct comprehensive multi-group bioinformatics analysis based on the expression cuproptosis-related genes (CRGs) identify novel cancer subtypes guide clinical practice. We collected TCGA-BRCA GSE42568 datasets investigate patterns CRGs Consensus cluster performed distinct subtypes. Subsequently, an...
Background: RP11-480I12.5 is a newly identified long noncoding RNA (lncRNA) that has never been studied in breast cancer. The biological function of carcinoma and its underlying mechanism are still unknown. Methods: We scanned the Cancer Genome Atlas (TCGA) database as one most dysregulated lncRNAs. level was assessed cancer (BC) tissue samples BC cell lines. prognostic value expression using Kaplan-Meier method. influence on lines proliferation, Transwell migration, invasion assays....
Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute this process. In study, freshly isolated biopsied cells obtained from consenting patients were subjected flow cytometry and bioinformatic analysis identify three endothelial cell subclusters: EC (ATP1B3), (HSPA1B), (KRT7) tumor microenvironment. These subclusters exhibited distinguishing biological features. Based on differentially expressed...
Adamantinoma craniopharyngioma (ACP) is a non-malignant tumour of unknown pathogenesis that frequently occurs in children and has malignant potential. The main treatment options are currently surgical resection radiotherapy. These treatments can lead to serious complications greatly affect the overall survival quality life patients. It therefore important use bioinformatics explore mechanisms ACP development progression identify new molecules.Sequencing data was downloaded from comprehensive...
Neoadjuvant chemotherapy (NAC) is an important treatment for breast cancer (BC) patients. However, due to the lack of specific therapeutic targets, only 1/3 human epidermal growth factor receptor 2 (HER2)-negative patients reach pathological complete response (pCR). Therefore, there urgent need identify novel biomarkers distinguish and predict NAC sensitive in BC patients.The GSE163882 dataset, containing 159 treated with NAC, was downloaded from Gene Expression Omnibus (GEO) database....
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) has been reported to have good antitumor effects. The aim of this study was investigate whether DMDD induces apoptosis and autophagy in human cholangiocarcinoma (CCA) QBC939 cells determine its effect on the PI3K/AKT/mTOR signaling pathway.QBC939 were cultured vitro changes cell viability detected by Cell Counting Kit (CCK8) assay after treatment with different concentrations for 24, 48, 72 h. divided into control DMDD-treated groups...
Background: Advanced platelet-rich fibrin extract (APRFE) contains a high concentration of various cytokines that are helpful for improving stem cells repair function. Objective: However, the underlying mechanism APRFE cell repairing is not clear. Methods: We produced by centrifuging fresh peripheral blood samples and isolated identified human adipose-derived mesenchymal (ADMSCs). The abundance contained in was detected Enzyme-linked immunosorbent assay (ELISA). ADMSCs treated with or...
Human epidermal growth factor receptor 2 (HER2) is a landmark protein in determining the targeted treatment of breast cancer (BC). However, latest research shows that different intensity HER2 expression levels BC leads to clinical characteristics, treatment, and prognosis, especially low patients. Therefore, this study intends analyze compare clinicopathologic features prognosis patients with zero from The Cancer Genome Atlas (TCGA) database data collected by our center.First, dataset was...
Abstract Background: Mitochondrial fission regulator 2 (MTFR2) belongs to the MTFR1/ family with sequence similarity 54 (FAM54) family. Recently, it was reported that MTFR2 promotes proliferation and invasion of breast cancers (BCs). However, relationship between endocrine crine therapy resistance is still unknown. Materials methods: We collected 36 ER+ BC tissues adjacent normal 10 samples from patients who received therapy. detected expression pattern fold change in cells treated tamoxifen...