A5100394332- Ferroptosis and cancer prognosis
- Acute Ischemic Stroke Management
- Cancer Cells and Metastasis
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Genital Health and Disease
- Neurobiology of Language and Bilingualism
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Traumatic Brain Injury Research
- Natural product bioactivities and synthesis
- Gene expression and cancer classification
- Alkaline Phosphatase Research Studies
- Physiological and biochemical adaptations
- Posttraumatic Stress Disorder Research
- RNA and protein synthesis mechanisms
Suzhou Institute of Systems Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2022-2024
National Institute of Environmental Health Sciences
2023
General Hospital of Guangzhou Military Command
2023
West Virginia University
2023
Shanghai Jiao Tong University
2018-2022
XinHua Hospital
2021-2022
Zhejiang University
2020
Binzhou People's Hospital
2015-2019
Data regarding human papillomavirus (HPV) prevalence and genotype distribution are limited in Shandong Province, China. Therefore, we investigated the recent HPV among females aimed to provide comprehensive data guide HPV-based cervical cancer screening vaccination for this population of Chinese women.HPV testing results 94,489 were retrospectively reviewed extracted from database Jinan KingMed Diagnostics, largest independent pathology laboratory was detected by a genotyping panel January...
Retinoic acid (RA) is the proposed mammalian 'meiosis inducing substance'. However, evidence for this role comes from studies in fetal ovary, where germ cell differentiation and meiotic initiation are temporally inseparable. In postnatal testis, these events separated by more than 1 week. Exploiting difference, we discovered that, although RA required spermatogonial differentiation, it dispensable subsequent initiation, progression completion of meiosis. Indeed, absence RA, transcriptome...
Abstract The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction CD8 + cells. Continuous antigen stimulation disrupts the expansion, effector function, metabolic fitness cells, leading to their differentiation into an exhausted state within tumor microenvironment (TME). While function cycle negative regulator p16 in senescent cells well understood, its role exhaustion remains unclear. In this study, we demonstrated that TCR rapidly...
STC1 is a glycoprotein hormone involved in calcium/phosphate (Pi) homeostasis. There mounting evidence that tightly associated with the development of cancer. But function cancer not fully understood. Here, we found down-regulated Clinical tissues cervical compared to adjacent normal (15 cases). Subsequently, expression was knocked down by RNA interference CaSki cells and low promoted cell growth, migration invasion. We also overexpression inhibited proliferation invasion cells. Moreover,...
To investigate the expression pattern of gamma-aminobutyric acid A (GABAA) receptors in hepatocellular carcinoma (HCC) and indicate relationship among (GABA), receptor alpha3 subunit (GABRA3) HCC.HCC cell line Chang, HepG2, normal liver L-02 8 samples HCC tissues paired non-cancerous were analyzed with semiquantitative polymerase chain reaction (PCR) for GABAA receptors. HepG2 cells treated (GABA) at serial concentrations (0, 1, 10, 20, 40 60 micromol/L), their proliferating abilities 3-(4,...
Liver transplantation is the only definitive treatment for end-stage liver disease and its availability restricted by organ donor shortages. The development of bioengineering provides probability to create a functional alternative reduce gap in demand supply. Decellularized scaffolds have been widely applied because they can mimic native microenvironment retain extracellular matrix (ECM) components. Multiple approaches including chemical, physical biological methods developed...
High-risk human papillomavirus (hrHPV) infection has been associated with a higher probability of progression to cervical cancer. However, several extensive studies have reported that the presence hrHPV can lead better prognosis, but mechanism how this occurs is unclear. In study, microbiological analysis was used identify HPV as factor for prognosis patients squamous cell carcinoma (CSCC). Comparing interactions + and - malignant cells immune well trajectory either or without HPV, we found...
To investigate the efficacy of recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis in combination with mild hypothermia therapy treatment acute cerebral infarction.One hundred and thirty-two patients infarction who were admitted to our hospital selected grouped into a control group an observation group, 66 each group. Patients given conventional local therapy, rt-PA on basis therapy. National institute health stroke scale (NIHSS) score intracranial pressure (ICP) two...
Background The metabolic characteristics of premature ovarian insufficiency (POI), a reproductive endocrine disease characterized by abnormal sex hormone metabolism and follicle depletion, remain unclear. Metabolomics is powerful tool for exploring phenotypes biomarkers. This study aims to identify markers construct diagnostic models, elucidate the underlying pathological mechanisms POI. Methods Non-targeted metabolomics was utilized characterize plasma profile 40 patients. were identified...
Abstract Background Cornichon homolog 4 (CNIH4) belongs to the CNIH family. It functions as an oncogene in many tumors. However, CNIH4's significance immune landscape and its predictive potential cervical cancer (CESC) is unexplored. Methods CNIH4 levels effect on survival of patients with CESC were evaluated using data retrieved from The Cancer Genome Atlas (TCGA). oncogenic was determined small interfering RNA‐mediated transfected cell lines tumorigenesis experiments animal models. Results...
There is a severe lack of aphasia screening tools for bedside use in Chinese. A number assessment have recently been developed abroad, but some these scales were not suitable patients with acute stroke. The Language Screening Test (which includes two parallel versions [a/b]) French has proven to be an effective and time-saving scale early-stage stroke patients. Therefore, we worked out Chinese version the LAST taking into consideration language culture. Two preliminary (a/b) tested on 154 at...
Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute this process. In study, freshly isolated biopsied cells obtained from consenting patients were subjected flow cytometry and bioinformatic analysis identify three endothelial cell subclusters: EC (ATP1B3), (HSPA1B), (KRT7) tumor microenvironment. These subclusters exhibited distinguishing biological features. Based on differentially expressed...
Endometriosis (EMT) is an aggressive disease of the reproductive system, also called "benign cancer". However, effective treatments for EMT are still lacking in clinical practice. Interestingly, immune infiltration significantly involved pathogenesis. Currently, no studies have shown involvement cuproptosis-related genes (CRGs) regulating EMT. This study identified three CRGs such as GLS, NFE2L2, and PDHA1, associated with using machine learning algorithms. These were upregulated endometrium...
Osteoarthritis (OA) is a degenerative disease characterized by articular cartilage and/or chondrocyte destruction, and although it has long been considered as primary disease, the importance of meniscus endothelial cell modulation in subchondral microenvironment recently drawn attention. Previous studies have shown that apelin could potentially inhibit cellular apoptosis; however, remains unclear whether play protective role protecting endothelium OA meniscus. In this study, with advantages...
Background: Tumor purity is defined as the proportion of cancer cells in tumor tissue, and its effects on molecular genetics, immune microenvironment, prognosis children’s central nervous system (CNS) tumors are under-researched. Methods: We applied random forest machine learning, InfiniumPurify algorithm, ESTIMATE algorithm to estimate every child’s CNS sample several published pediatric datasets from Gene Expression Omnibus (GEO), aiming perform an integrated analysis tumors. Results: Only...
Abstract Ethnopharmacological relevance: Prunellae spica belongs to the Labiatae family and it clears liver purges fire, improves vision, disperses swelling. Clinically, plays diverse antibacterial, antiviral, anti-cancer roles is involved in immune regulation but its mechanism of action unknown for exerting therapeutic effects. This study comprehensively analyzes Spica Endometrial cancer (EC) based on multiple databases such as Network Pharmacology TCGA, which will help provide new ideas...
Background Radiotherapy plays a crucial role in the management of Cervical cancer (CC), as development resistance by cells to radiotherapeutic interventions is significant factor contributing treatment failure patients. However, specific mechanisms that contribute this remain unclear. Currently, molecular targeted therapy, including mitochondrial genes, has emerged new approach treating different types cancers, gaining attention an area research addressing challenge radiotherapy cancer....
To detect desialylation of platelets in primary immune thrombocytopenia(ITP) patients with FITC-labelled ECL and RCA-1, compare the correlation level efficacy first-line therapy for ITP.Before treatment, 48 ITP were selected their levels RCA-1 detected flow cytometry.The different groups by using corticosteroids (or) intravenous immunoglobulin G (IVIG) had a statistically significant difference (P<0.05). The analysis showed negative relation therapeutic level, that is to say, more high poor...
Abstract Endometriosis (EMT) is a chronic hormone-dependent disease where in viable endometrial tissue transplanted outside the uterus. Interestingly, immune infiltration significantly involved EMT pathogenesis. Currently, no studies have shown involvement of cuproptosis-related genes (CRGs) regulating EMT. This study identified three CRGs such as GLS, NFE2L2, and PDHA1, associated with using machine learning algorithms. These were upregulated endometrium patients moderate/severe...
To compare the in vitro antitumor immune responses induced by bivalent bispecific anti-idiotype antibody G22-I50 and monovalent G22 I50, explore its possible mechanism.Proteins G22-I50, G22, I50 were identified Western blot ELISA. Peripheral blood monoclear cells (PBMC) isolated stimulated with antibodies, respectively. MTT assay LDH release test employed to examine proliferation cytotoxicity of PBMC. The levels IFN-gamma, IL-2, IL-4 supernatant detected ELISA changes T lymphocyte subsets...
The lack of effective and rapid aphasia screening scales for early post-stroke patients can lead to less rehabilitation gains unquestionable. Language Screening Test (LAST-a LAST-b two parallel versions which were established avoid retest bias) is the first scale that was confirmed patients. We reconstructed Mandarin (MLAST-a MLAST-b) based on primary ones evaluated their validity reliability. Based original edition's design principal combined with characteristics Chinese our culture, 2...
Diffuse Intrinsic Pontine Glioma (DIPG) remains to be a lethal type of pediatric brain tumor date, indicating an urgent need finding novel therapeutic strategy. Through screening collection anti-tumor agents against patient-derived DIPG primary cell line, we identified few candidates for treating DIPG, among which BIRC5 inhibitor YM155 was the top potent agent. Next, confirmed that could selectively inhibit multiple lines with IC50 less than 10nM. Moreover, our gene expression analyses...