A5063371130- Inflammasome and immune disorders
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Autophagy in Disease and Therapy
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Enterobacteriaceae and Cronobacter Research
- Phagocytosis and Immune Regulation
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Dermatology and Skin Diseases
- NF-κB Signaling Pathways
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
New York University
2019-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2021-2024
Nanjing Agricultural University
2017-2022
Zhejiang Pharmaceutical College
2019-2022
Ningbo University
2022
Wuhan University
2021
AbbVie (United States)
2021
Janssen (Belgium)
2021
Ferring Pharmaceuticals (Switzerland)
2021
Allergan (France)
2021
Inflammasomes are involved in gut homeostasis and inflammatory pathologies, but the role of NLRP3 inflammasome these processes is not well understood. Cryopyrin-associated periodic syndrome (CAPS) patients with mutations have autoinflammation skin, joints, eyes, intestine. Here we show that intestines CAPS model mice carrying an Nlrp3 R258W mutation maintain gut. Additionally, such strongly resistant to experimental colitis colorectal cancer; this mainly through a remodelled microbiota...
Although Western diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), corresponding host cellular mechanisms remain poorly defined. Here we report that TSC1/mTOR pathway in gut epithelium represents a metabolic innate immune checkpoint for intestinal dysfunction inflammation. mTOR hyperactivation triggered by or Tsc1 ablation led to necroptosis, barrier disruption, predisposition dextran sulfate sodium-induced colitis...
NLRP3 inflammasome activiation requires two sequential signals. The priming signal 1 from TLRs or cytokine receptors induces the transcription of and IL-1β, concomitantly promotes transcription-independent activation caspase-1. activating 2 can be provided by microbial products danger In this study we found that TRAF6 is necessary for nontranscriptional TLR/IL-1R derived Deficiency specifically inhibited priming-initiated caspase-1 cleavage, pyroptosis, secretion presynthesized IL-18....
Background Mycoplasma hyorhinis (M.hyorhinis, M.hy) is associated with development of gastric and prostate cancers. The NLRP3 inflammasome, a protein complex controlling maturation important pro-inflammatory cytokines interleukin (IL)-1β IL-18, also involved in tumorigenesis metastasis various Methodology/Principal Findings To clarify whether M.hy promoted tumor via inflammasome activation, we analyzed monocytes for IL-1β IL-18 production upon challenge. When exposed to M.hy, human exhibited...
Systemic lupus erythematosus (SLE) is an autoimmune syndrome associated with severe organ damage resulting from the activation of immune cells. Recently, a role for caspase-1 in murine was described, indicating involvement inflammasomes development SLE. Among multiple identified, NLRP3 inflammasome connected to diverse diseases, including encephalomyelitis. However, function SLE remains elusive. In this study, we explored using pristane-induced experimental model. It discovered that more...
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune microbial factors that permit GI remain unknown. Male sex correlated enhanced nasal carriage, skin soft tissue infections, bacterial sepsis. Here, we established mouse model sexual dimorphism during MRSA. Our results show contrast to male mice were susceptible persistent colonization, female rapidly...
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune microbial factors that permit GI remain unknown. Male sex correlated enhanced nasal carriage, skin soft tissue infections, bacterial sepsis. Here, we established mouse model sexual dimorphism during MRSA. Our results show contrast to male mice were susceptible persistent colonization, female rapidly...
Abstract Background Extrauterine growth restriction (EUGR) represents a prevalent condition observed in preterm neonates, which poses potential adverse implications for both neonatal development and long-term health outcomes. The manifestation of EUGR has been intricately associated with perturbations microbial metabolic profiles. This study aimed to investigate the characteristics gut network early colonizers among neonates EUGR. Methods Twenty-nine infants participated this study,...
Abstract The inflammasomes play critical roles in numerous pathological conditions largely through IL-1β and/or IL-18. However, additional effectors have been implied from multiple studies. In this study, two independent mass spectrometry–based secretome screening approaches, we identified galectin-3 as an effector protein of the NLRP3 inflammasome. Although activation AIM2 or NLRC4 inflammasome also led to secretion, only controlled serum level under physiological condition....
Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade variety of intracellular cargo, thus providing quality control over cellular components and maintaining regulatory functions. triggered by multiple stimuli ranging from nutrient starvation microbial infection. extensively shapes modulates the inflammatory response, concerted action immune cells, secreted mediators aimed eradicate infection or heal sterile tissue damage. Here, we first review how autophagy...
Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a histone 3 lysine 36 (H3K36) specific methyltransferase that frequently deleted in (WHS). Whsc1 also found mutated subgroup of B-cell derived malignant diseases by genomic translocation or point mutation, both which resulted hyperactivity WHSC1 mediated H3K36 methylation and uncontrolled cell proliferation, suggesting whsc1 functions as an oncogene. However, here we provided evidences to show has tumor suppressor functions. We used zebrafish...
Significant research progress has recently been made on establishing the roles of tps46 in rice defense. (E)-β-farnesene (Eβf) is a major product activity but its physiological functions and potential mechanisms against Chilo suppressalis have not yet clarified. In present study, C. larvae were artificially fed diet containing 0.8 g/kg Eβf performance was evaluated. response to treatment, average 2nd instar duration significantly increased from 4.78 d 6.31 while that 3rd 5.70 8.00 compared...
Adult-onset neuronal ceroid lipofuscinosis (ANCL), one of the (NCLs), is an inherited neurodegenerative disorder with progressive dysfunction. Recently, mutations in DNAJC5 gene that encodes cysteine-string protein alpha (CSPα) have been reported to be associated familial autosomal-dominant ANCL (AD-ANCL). This study constructed transgenic zebrafish model expressing human mutant (mDNAJC5) under control a neuron-specific promoter. To investigate whether therapy based on genome-editing...
Abstract An obvious challenge faced by most terrestrial insects is maintaining water homeostasis in an arid environment. Current research suggests aquaporins may be evolved to meet the challenge. However, up now, this suggestion has not been verified any insect that feeds upon solid food with mandibulate mouthparts. In present paper, nine putative aquaporin genes [ Tribolium castaneum big brain , T. Drosophila integral protein ( TcDrip ), Pyrocoelia rufa TcPrip 12‐like entomoglyceroporin 1...
Translational control is a critical step in the regulation of gene expression. Accumulating evidence shows that translational subgroup mRNAs tends to be selective. However, our understanding function selective endothelial cells still incomplete. We found key regulator, eIF3i, highly expressed during embryonic and tumor angiogenesis. Knockdown eIF3i restrained cell proliferation migration cells. In zebrafish angiogenesis model, mutant could not respond induction signals from mass....
Adamantinoma craniopharyngioma (ACP) is a non-malignant tumour of unknown pathogenesis that frequently occurs in children and has malignant potential. The main treatment options are currently surgical resection radiotherapy. These treatments can lead to serious complications greatly affect the overall survival quality life patients. It therefore important use bioinformatics explore mechanisms ACP development progression identify new molecules.Sequencing data was downloaded from comprehensive...