A5017232463- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Kidney Disease and Diabetes
- Research on Leishmaniasis Studies
- Phagocytosis and Immune Regulation
- Polyamine Metabolism and Applications
- Toxoplasma gondii Research Studies
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- RNA regulation and disease
- Invertebrate Immune Response Mechanisms
- Calcium signaling and nucleotide metabolism
- Nuclear materials and radiation effects
- Inhalation and Respiratory Drug Delivery
- Parasitic infections in humans and animals
- Glutathione Transferases and Polymorphisms
- CRISPR and Genetic Engineering
- Advanced Glycation End Products research
- Immune Response and Inflammation
- Aldose Reductase and Taurine
- Cellular transport and secretion
- Viral Infections and Immunology Research
Jamia Hamdard
2024-2025
Institute of Life Sciences
2018-2023
The University of Texas Health Science Center at Houston
2011-2013
Jawaharlal Nehru University
1999-2009
Several large-scale genome-wide association studies genetically linked IRGM to Crohn's disease and other inflammatory disorders in which the appears have a protective function. However, mechanism by accomplishes this anti-inflammatory role remains unclear. Here, we reveal that IRGM/Irgm1 is negative regulator of NLRP3 inflammasome activation. We show expression, increased PAMPs, DAMPs, microbes, can suppress pro-inflammatory responses provoked same stimuli. negatively regulates IL-1β...
Article24 August 2018Open Access Source DataTransparent process TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis autophagy Kautilya Kumar Jena Cell Biology Infectious Diseases Unit, Institute Life Sciences, Bhubaneswar, India School Biotechnology, KIIT University, Search for more papers this author Srinivasa Prasad Kolapalli Subhash Mehto orcid.org/0000-0002-5351-7850 Parej Nath Biswajit Das Tumor Microenvironment Animal Models, Manipal Manipal,...
Background: Diabetic nephropathy, a major contributor to chronic kidney disease, is closely associated with inflammatory responses. Objective: This study aimed evaluate the effectiveness of combination therapy dapagliflozin and telmisartan in treating diabetic nephropathy its effect on patient’s albuminuria levels. Material Methods: We conducted 12-week prospective observational assess nephropathy. Patients were treated either (n=92) or alone (n=92). Measurements waist-to-hip ratio, fasting...
Abstract The NOD1/2‐RIPK2 is a key cytosolic signaling complex that activates NF‐κB pro‐inflammatory response against invading pathogens. However, uncontrolled can cause tissue damage leading to chronic diseases. mechanisms by which the NODs‐RIPK2‐NF‐κB innate immune axis activated and resolved remain poorly understood. Here, we demonstrate bacterial infection induces formation of endogenous RIPK2 oligomers (RIPosomes) are self‐assembling entities coat bacteria induce response. Next, show...
Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays central role in eliminating toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses unique trypanothione dependent system.Analysis L. GLOI sequence predicted mitochondrial targeting sequence, suggesting enzyme likely to be targeted mitochondria. In order determine definitively intracellular localization donovani, full-length gene was fused green fluorescent protein (GFP) generate chimeric...
Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade variety of intracellular cargo, thus providing quality control over cellular components and maintaining regulatory functions. triggered by multiple stimuli ranging from nutrient starvation microbial infection. extensively shapes modulates the inflammatory response, concerted action immune cells, secreted mediators aimed eradicate infection or heal sterile tissue damage. Here, we first review how autophagy...
sGC (soluble guanylate cyclase) is the main mediator of NO signalling. Biochemical and physiological studies suggest that, besides NO, in vivo regulation involves direct interaction with other proteins. Using yeast two-hybrid screening, we identified that multidomain LGN (Leu-Gly-Asn repeat-enriched protein) interacts both α1 β1 subunits. co-localized cell cytoplasm, LGN–sGC complex was co-immunoprecipitated from cells expressing proteins native tissues. Their requires N-terminal...
The NOD1-NOD2-RIPK2-NFKB/NF-κB pro-inflammatory axis plays a significant role in regulating the immune response to bacterial infection. However, an excess of NFKB-dependent cytokine can be detrimental and, thus, should kept under control maintain innate balance. In our recent study, first, we showed that infection induces biogenesis RIPK2 oligomers (RIPosomes) are recruited around bacteria enhance response. Next, SQSTM1- and IRGM-dependent selective macroautophagy/autophagy degrades...
Protein misfolding and protein aggregation are linked to several diseases commonly called as proteinopathies, which include cancer. Understanding the mechanisms of proteostasis could provide newer strategies combat proteinopathies. We have recently demonstrated a new mechanism where we found that TRIM16 (tripartite motif-containing 16) utilizing NRF2-p62 axis autophagy streamlines safe disposal misfolded proteins maintain homeostasis.
Background Cyclic GMP producing soluble guanylyl cyclase (sGC) is highly activated by the binding of nitric oxide (NO) messenger to its heme. Besides NO, other NO-independent molecules were shown activate sGC. These include a class heme-replacers (e.g., protoporphyrin IX and structurally unrelated activators BAY 58-2667 HMR1766) or sGC stimulators 41-2272 YC-1 aryl-acrylamide derivatives). The later requires heme sensitize low NO concentrations. Collectively these data suggest that various...
Background Nitric oxide binds with the heme moiety of sGC and activates several hundred folds cGMP-forming activity enzyme. Although nitric is major physiological regulator function, extent this activation influenced by a number cellular factors, e.g. ATP, substrate GTP, reaction products, intracellular calcium, etc. Several proteins, such as HSP70, HSP90 CCTh, where shown to interact modulate its function.
Soluble guanylyl cyclase (sGC) is a heme‐containing enzyme which converts GTP to cGMP. SGC referred as nitric oxide (NO) receptor, it strongly stimulated by NO. Although the mechanism of sGC activation NO received lot attention, processes deactivation are less understood. In this report we demonstrate inhibition LGN‐dependent mechanism. LGN known regulator Gα proteins. We identified protein interacting with both α1 and β1 subunits yeast two‐hybrid screening co‐immunoprecipitation from BE2...