A5101651540- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Long-Term Effects of COVID-19
- Pharmacological Effects of Natural Compounds
- Respiratory viral infections research
- Cardiac Fibrosis and Remodeling
- Andrographolide Research and Applications
- Diverse Scientific Research Studies
- Traditional Chinese Medicine Studies
- Medicinal Plant Pharmacodynamics Research
- Viral gastroenteritis research and epidemiology
- Medicinal Plants and Bioactive Compounds
- Hydrogen's biological and therapeutic effects
- Heavy Metal Exposure and Toxicity
- Orthodontics and Dentofacial Orthopedics
- COVID-19 diagnosis using AI
- Fetal and Pediatric Neurological Disorders
- Bioactive Compounds and Antitumor Agents
- interferon and immune responses
- Synthesis and Biological Evaluation
- Plant-based Medicinal Research
- Synthesis and biological activity
- Chromatography in Natural Products
- Cardiac Arrhythmias and Treatments
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2023-2025
Zhejiang Chinese Medical University
2025
Institute of Laboratory Animal Science
2018-2024
Icahn School of Medicine at Mount Sinai
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2024
National Clinical Research Center for Digestive Diseases
2024
Air Force Medical University
2024
Loma Linda University
2020-2021
Nanjing Medical University
2021
AbbVie (United States)
2021
With the unprecedented morbidity and mortality associated with COVID-19 pandemic, a vaccine against is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated candidate COVID-19, containing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for its safety, tolerability immunogenicity.In this randomised, double-blind, placebo-controlled, phase 1/2 clinical trial, healthy adults aged 18-59 years were recruited from community in Suining...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging new type of that responsible for the COVID-19 pandemic and unprecedented global health emergency. Whole-genome sequencing (WGS) SARS-CoV-2 plays a critical role in understanding disease. Performance variation exists across viral WGS technologies, but there currently no benchmarking study comparing different protocols. We compared seven library protocols using RNA from patient nasopharyngeal swab samples under two...
ABSTRACT Respiratory syncytial virus (RSV) is the most commonly identified viral agent in young children with acute respiratory tract infections (ARIs) and often causes repeated throughout life. This study investigated genetic variability of attachment (G) protein gene among RSV strains prevalent southwestern China. Reverse transcription-PCR (RT-PCR) for a fragment G was performed nasopharyngeal aspirates (NPAs) collected from ARIs hospitalized Chongqing Children's Hospital, Chongqing, A...
Nonalcoholic fatty liver disease (NAFLD), a condition caused by buildup of fat in cells because wrong choices and nutrition intake patterns over time, is common chronic metabolic disorder among individuals today. Narciclasine (Nar), compound present Haemanthus coccineus L., has been noted for its strong anti-inflammatory effects. However, impact on regulating imbalances associated with NAFLD requires further investigation. In this research investigation using mice induced high-fat diet (HFD)...
Abstract Novel coronavirus disease 2019 (COVID-19) is an emerging, rapidly evolving crisis, and the ability to predict prognosis for individual COVID-19 patient important guiding treatment. Laboratory examinations were repeatedly measured during hospitalization patients, which provide possibility individualized early prediction of prognosis. However, previous studies mainly focused on risk based laboratory measurements at one time point, ignoring progression changes biomarkers over time. By...
Background: Heart failure (HF) is a chronic disease with poor prognosis, making it extremely important to assess the prognosis of patients HF for accurate treatment. Secreted modular calcium-binding protein 2 (SMOC2) cysteine-rich acidic secreted that plays pathophysiological role in many diseases, including regulation vascular growth factor activity. It has previously been found SMOC2 an essential cardiac fibrosis our previous preclinical study, but whether can be used as clinical marker...
Hand, foot and mouth disease (HFMD) is a common infectious caused by viral infection variety of enteroviruses, with coxsackievirus A 10 (CA10) having become more prevalent in recent years.
Abstract The COVID-19 pandemic is a once-in-a-lifetime event, exceeding mortality rates of the flu pandemics from 1950’s and 1960’s. Whole-genome sequencing (WGS) SARS-CoV-2 plays critical role in understanding disease. Performance variation exists across viral WGS technologies, but there currently no benchmarking study comparing different protocols. We compared seven library protocols using RNA patient nasopharyngeal swab samples under two storage conditions. constructed multiple libraries...
Abstract Background Beyond systematic reviews and meta-analyses, there have been no direct studies of serological response to COVID-19 in patients with inflammatory bowel disease (IBD) across continents. In particular, has limited data from Asia, reported India. The ICARUS-IBD (International study Antibody Response Under Sustained immunosuppression IBD) consortium assessed SARS-CoV-2 IBD North America, Europe, Asia. Methods is a multicenter observational cohort spanning sites 7 countries. We...
Background Implantable cardioverter defibrillator (ICD) is the only effective therapy in patients with life threatening ventricular arrhythmias. Inappropriate detection and by ICDs are most common causes of side effects that affect quality ICD recipients. This study evaluated incidence inappropriate our hospital. Methods From January 2000 to December 2005, fifty who received implantation for arrhythmias prevention sudden cardiac death were this study. Each was programmed using clinical...
Abstract Background: The coronavirus disease 2019 (COVID-19) causing a cluster of respiratory infections in Wuhan, China, is identified December 2019. main symptoms are defined as fever, cough, shortness breath, with early symptom sputum, acute distress syndrome (ARDS), and the final lung injury pulmonary fibrosis. Currently, there no effective method to cure it. Mesenchymal stem cell (MSC) therapy an immediate need for treating COVID-19 especially severe patients at present. Methods: We...
Abstract While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID-19 vaccine development, we screened 235 IBD biological therapy for antibodies measured serum cytokines. In seropositive patients, prospectively collected clinical data. We found a cytokine signature who compared seronegative that may be linked...