A5075001791- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Congenital heart defects research
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Surgical site infection prevention
- Wound Healing and Treatments
- Ubiquitin and proteasome pathways
- Biliary and Gastrointestinal Fistulas
- Pregnancy and preeclampsia studies
- Antimicrobial agents and applications
- Protein Tyrosine Phosphatases
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Pluripotent Stem Cells Research
- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
Sun Yat-sen University
2022-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2022-2025
Abstract Photosensitizers (PSs) with effective reactive oxygen species generation ability against hypoxia are of great potential for clinical treatment malignant tumors. However, complex tumor microenvironment, such as antioxidative responses and immunosuppression, would ineluctably limit the efficiency photodynamic therapy (PDT). Herein, a molecular‐targeting photosensitizer QTANHOH is rationally designed histone deacetylases (HDACs‐targeting photo‐immunotherapy application. The PS displays...
Abstract Persistent inflammation and disrupted immunoregulation are critical factors in impeding diabetic wound healing. While immunoregulatory hydrogel dressings hold significant promise for clinical applications healing, the current application often demands intricate interventions high‐cost treatments involving cytokines cell therapies. The development of single component hydrogels remains a complex challenge. To address this issue, an active peptide with properties targeting TLR4/NF‐kB...
Liver cancer, especially hepatocellular carcinoma (HCC), remains a significant global health challenge. Traditional prognostic indicators for HCC often fall short in providing comprehensive insights individualized treatment. The integration of genomics and radiomics offers promising avenue enhancing the precision diagnosis prognosis.From Cancer Genome Atlas (TCGA) database, we categorized mRNA patients by Forkhead Box M1 (FOXM1) expression performed univariate multivariate studies to...
Portal hypertension (PHT) is an important factor leading to a poor prognosis in patients with hepatocellular carcinoma (HCC). Identifying PHT for individualized treatment of great clinical significance. The prediction model HCC combined urgent need practice. Combining parameters and imaging features can improve accuracy. application artificial intelligence algorithms further tap the potential data, optimize model, provide strong support early intervention personalized PHT. This study aimed...
Background The bioactive compound 2-Dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD), derived from the horn root of star fruit, exhibits therapeutic promise through its modulation TGF-β1 pathway and regulation bile acids. Methods In this study, a liver fibrosis model was established in Kunming mice (KM) induced by carbon tetrachloride (CCL4), DMDD (50 mg/kg) administered intragastrically. HE staining, Masson Sirius staining were used to evaluate effect on fibrosis. Illumina sequencing...
Hepatocellular carcinoma (HCC) is a common malignancy associated with high morbidity and mortality rates worldwide. To improve the prognosis of HCC, early diagnosis crucial. However, to date, little known about role natural killer cell-related genes (NKCRGs) in predicting hepatocellular patients. In this study, we identified 24 differentially expressed NKCRGs HCC specimens from TCGA dataset, including 22 upregulated 2 downregulated genes. Functional enrichment analysis revealed that these...
Nonalcoholic fatty liver disease (NAFLD) is a serious disease. There are no specific drugs for it, in part because of the lack effective models to aid drug development. However, it has been shown that three-dimensional organoid culture systems can reproduce organ structure and maintain gene expression profile original tissue. Therefore, we aimed construct NAFLD from organoids pharmacological mechanism studies. We successfully observed morphological changes normal tissue mouse with positive...
The simultaneous differentiation of human pluripotent stem cells (hPSCs) into both endodermal and mesodermal lineages is crucial for developing complex, vascularized tissues, yet poses significant challenges. This study explores a method co-differentiation mesoderm endoderm, their subsequent pancreatic progenitors (PP) with endothelial (EC). Two hPSC lines were utilized. By manipulating WNT signaling, we optimized protocols endoderm through adjusting the concentrations CHIR99021 mTeSR1....
<title>Abstract</title> Background Hepatocellular carcinoma (HCC) is a common malignant digestive tract tumor worldwide. Disulfidptosis and entosis are two special cell death mechanisms. The purpose of this study was to investigate the prognostic clinical applicability these death-related genes in HCC. Methods R package "Deseq2" used conduct differential expression analysis, 22 disulfidptosis-related 25 entosis-related were screened out 15 genes, 8 key subsequently by single-factor Cox...
Background. A large number of cancer-related deaths in the world can be attributed to liver hepatocellular carcinoma (LIHC). The purpose this study is explore protein tyrosine phosphatase type IV member 3 (PTP4A3/PRL-3) as a new and reliable biomarker predict prognosis LIHC determine potential therapeutic targets or drugs that used for treating LIHC. Methods. We included three datasets with clinical information expression profiles from public databases. level PTP4A3 was analyzed, based on...