A5100397141- Reproductive tract infections research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Parasitic Infections and Diagnostics
- Stress Responses and Cortisol
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- Cancer-related gene regulation
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Antifungal resistance and susceptibility
- Mitochondrial Function and Pathology
- Nutrition, Genetics, and Disease
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ion channel regulation and function
Nanchang University
2025
Beijing University of Chinese Medicine
2024
Institute of Plant Protection
2023-2024
Chinese Academy of Agricultural Sciences
2020-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Peking University
2017-2023
Columbia University
2009-2023
Shenyang Pharmaceutical University
2023
Guangzhou Medical University
2020-2022
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2022
Large-scale crotonylome reveals CDYL-regulated crotonylation in diverse functions including RPA-mediated HR DNA repair.
Chronic obstructive pulmonary disease (COPD) is an inflammatory that associated with increased risk of lung cancer.
Abstract The scope and variety of the metabolic intermediates from mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation chromatin function nucleus raise an outstanding question about how timely precise supply/consumption these metabolites is achieved nucleus. We report here identification a nonclassical TCA (nTCA cycle). found all cycle-associated enzymes including citrate synthase (CS), aconitase 2 (ACO2), isocitrate dehydrogenase 3 (IDH3), oxoglutarate...
Abstract Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role CD HF remains unclear. Here, we show hippocampal neurons from individuals mice with that the RyR2/intracellular Ca 2+ release channels were subjected post-translational modification (PTM) leaky. RyR2 PTM included protein kinase A phosphorylation, oxidation, nitrosylation...
Nitric oxide (NO) has been shown to be the endothelium-derived relaxing factor (EDRF), and its impairment contributes a variety of cardiovascular disorders. Recently, it recognized that nitrite can an important source NO; however, questions remain regarding activity mechanisms bioactivation in vessels physiological importance. Therefore, we investigated effects on vivo hemodynamics rats vitro vasorelaxation isolated rat aorta under aerobic conditions. Studies were performed determine by...
Cryptosporidium parvum is an enteric protozoan parasite that has emerged as a major cause of diarrhea, malnutrition, and gastroenteritis poses potential bioterrorism threat. C. synthesizes guanine nucleotides from host adenosine in streamlined pathway relies on inosine 5′-monophosphate dehydrogenase (IMPDH). We have previously identified several parasite-selective IMPDH (CpIMPDH) inhibitors by high-throughput screening. In this paper, we report the structure–activity relationship (SAR) for...
Monocyte chemoattractant protein (MCP)-1 plays a key role in atherosclerosis and inflammation associated with visceral adiposity by inducing mononuclear cell migration. Evidence shows that mouse peritoneal macrophages (MPM) express 12-lipoxygenase (12/15-LO) has been clearly linked to accelerated models increased monocyte endothelial interactions both rodent human cells. However, the of 12/15-LO products regulating MCP-1 expression not clarified. In this study, we tested using MPM macrophage...
Abstract. The ego depletion effect has been examined by over 300 independent studies during the past two decades. Despite its pervasive influence, recently this severely challenged and asserted to be a fake. Based on an up-to-date meta-analysis that effectiveness of each frequently used depleting task, we preregistered current experiment with aim examine whether there would when Stroop task is as task. results demonstrated significant effect. research highlights importance task’s...
The protozoan parasite Cryptosporidium parvum is responsible for significant disease burden among children in developing countries. In addition Cryptosporidiosis can result chronic and life-threatening enteritis AIDS patients, the currently available drugs lack efficacy treating these severe conditions. discovery development of novel anti-cryptosporidial therapeutics has been hampered by poor experimental tractability this pathogen. While genome sequencing effort identified several...
Cryptosporidium parvum and related species are zoonotic intracellular parasites of the intestine. is a leading cause diarrhea in small children around world. Infection can severe pathology immunocompromised patients. This waterborne parasite resistant to common methods water treatment therefore prominent threat drinking recreation even countries with strong safety systems. The drugs currently used combat these organisms ineffective. Genomic analysis revealed that relies solely on...
Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disorder affecting striatal neurons beginning in young adults with loss of muscle coordination and cognitive decline. Less appreciated the fact that patients HD also exhibit cardiac respiratory dysfunction, including pulmonary insufficiency arrhythmias. The underlying mechanism for these symptoms poorly understood. In present study we provide insight into cause cardiorespiratory dysfunction identify potentially...
Summary To compare the efficacy and safety of two doses clotrimazole vaginal tablet 500 mg with oral fluconazole 150 in treating severe vulvovaginal candidiasis ( SVVC ), 240 consecutive patients were studied at Department Obstetrics Gynaecology Peking University Shenzhen Hospital between June 2014, September 2015. Patients randomly assigned a 1 : ratio to receive treatment either or fluconazole. The clinical cure rates group days 7–14 follow‐up 88.7% (102/115) 89.1% (98/110) respectively;...
Hepatocellular carcinoma (HCC) is a common malignancy associated with high morbidity and mortality rates worldwide. To improve the prognosis of HCC, early diagnosis crucial. However, to date, little known about role natural killer cell-related genes (NKCRGs) in predicting hepatocellular patients. In this study, we identified 24 differentially expressed NKCRGs HCC specimens from TCGA dataset, including 22 upregulated 2 downregulated genes. Functional enrichment analysis revealed that these...
Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and morphogenetic processes organizing within it. We report that epidermal morphogenesis requires proper distribution of apical polarity determinant aPKC. Specifically, find roles for kinases GSK3 aPKC cellular alignment, asymmetric protein distribution, adhesion during development this polarized tissue. Finally, propose a...
Cry toxins are insecticidal toxin proteins produced by a spore-forming Gram-positive bacterium Bacillus thuringiensis. Interactions between the and receptors from midgut brush border membrane vesicles (BBMVs), such as cadherin, alkaline phosphatase, aminopeptidase, key steps for specificity activity of proteins. However, little is known about juice that may interfere with binding to receptors. To validate hypothesis there exist Cry-binding can process toxins, we applied Cry1Ab1-coupled...
Exploitation of naturally occurring genetic mutations could empower the discovery novel aspects established cancer genes. We report here that TRPS1, a gene linked to tricho-rhino-phalangeal syndrome (TRPS) and recently identified as potential breast driver, promotes carcinogenesis through regulating replication. Epigenomic decomposition TRPS1 landscape reveals nearly half H3K9me3-marked heterochromatic origins are occupied by where it encourages chromatin loading APC/C, resulting in...
Despite the established negative regulatory effects observed in various diseases like cardiovascular disease and diabetes, distinct impact of red cell distribution width (RDW) to albumin ratio (RAR) on mortality within realm rheumatoid arthritis (RA) remains obscure. This study sought explore relationship between RAR RA patients.