A5102775557- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Autoimmune Neurological Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Epilepsy research and treatment
- Long-Term Effects of COVID-19
- Transplantation: Methods and Outcomes
- Cancer-related gene regulation
- RNA modifications and cancer
- Organ and Tissue Transplantation Research
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- CRISPR and Genetic Engineering
- Infectious Encephalopathies and Encephalitis
- Diabetic Foot Ulcer Assessment and Management
- Cytomegalovirus and herpesvirus research
Institute of Hematology & Blood Diseases Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Air Force Medical University
2024
Xijing Hospital
2024
Dalian Medical University
2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Second Xiangya Hospital of Central South University
2021
Central South University
2021
Huazhong University of Science and Technology
2019
Abstract Mesenchymal stem cells (MSCs) possess potent immunomodulatory activity and have been extensively investigated for their therapeutic potential in treating inflammatory disorders. However, the mechanisms underlying immunosuppressive function of MSCs are not fully understood, hindering development standardized MSC-based therapies clinical use. In this study, we profile single-cell transcriptomes isolated from adipose tissue (AD), bone marrow (BM), placental chorionic membrane (PM),...
Abstract Single-cell RNA sequencing provides exciting opportunities to unbiasedly study hematopoiesis. However, our understanding of leukemogenesis was limited due the high individual differences. Integrated analyses hematopoiesis and potentially new insights. Here we analyzed ~200,000 single-cell transcriptomes bone marrow mononuclear cells (BMMCs) its subsets from 23 clinical samples. We constructed a comprehensive cell atlas as hematopoietic reference. developed counterpart composite...
Background and Objectives The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) is a scale for assessing severity autoimmune encephalitis. We aimed to validate the CASE score Chinese population evaluate its clinical significance. Methods Patients diagnosed with encephalitis were recruited between June 2014 May 2019 from two hospitals. modified Rankin (mRS) scores obtained. Data regarding features, treatment, available information gathered hospital system. Results Of 176 patients...
Diamond–Blackfan anemia (DBA) was the first ribosomopathy associated with mutations in ribosome protein (RP) genes. The clinical phenotypes of DBA include failure erythropoiesis, congenital anomalies and cancer predisposition. Mutations RPL5 are reported approximately 9 ~ 21 % patients, which represents most common pathological condition related to a large-subunit ribosomal protein. However, it remains unclear how downregulation results severe this disease. In study, we generated zebrafish...
Abstract Background Imbalance in bone formation and resorption is a crucial component of the pathological process leading to osteoporosis. Electromagnetic fields (EMFs) have been reported be beneficial osteogenesis, although exact mechanism has not fully clarified. Purinergic receptor P2X7 expressed osteoblasts participate regulation metabolism. Objectives To elucidate link between EMFs expression investigate its potential as novel therapeutic target Method We investigated effect on...
Abstract Objectives Existing data regarding the risk of COVID‐19 infection and its effects on seizure control in patients with epilepsy (PWE) are inconclusive. Our research aims to investigate PWE who susceptible what factors contribute exacerbation. Methods From Dec 28, 2022 Feb 19, 2023, a cross‐sectional questionnaire survey among adult was conducted. The demographics, epilepsy‐related information, COVID‐19‐related variables, outcomes after were collected. Multivariate logistic analyses...
Bone marrow (BM) is the dominant site of hematopoiesis after 20 post-conception weeks (PCWs), but intricacies hematopoietic development in fetal BM up to birth and its involvement malignancies remain unknown. Here, we compared single-cell transcriptomic profile stem progenitor cells (HSPCs) at early (12–14 PCW), middle (19–22 PCW) second trimester, neonatal stage. The stemness cell multipotent (HSC/MPP) established then maintained until birth. Furthermore, differentiation potentials toward...
Pediatric acute myeloid leukemia (pAML) is a clonal disease with recurrent genetic alterations that affect epigenetic states. However, the implications of dysregulation in progression remain unclear. Here, we interrogated single-cell and level chromatin accessibility bone marrow samples from 28 pAML patients representing multiple subtypes using mtscATAC-seq, which revealed distinct differentiation hierarchies abnormal subtype-specific manner. Innate immune signaling was commonly enhanced...
Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder in human bone marrow. Over 50% of patients with have mutations JAK2, MPL, or CALR. However, these are rarely detected children, suggesting difference the pathogenesis childhood PMF. In this study, we investigated response to drug treatment monozygotic twin pair typical The exhibited different clinical outcomes despite following same regimen. transcriptomic profiles patient samples after (E2 and Y2) were significantly...
A 64-year-old woman underwent gastroscopy and abdominal computed tomography, which revealed a 4.0 × 3.5 cm gastric gastrointestinal stromal tumor (GIST) in the anterior wall of stomach ([Fig. 1 a]). After full evaluation, an endoscopic full-thickness resection technique was used to achieve complete b]). It is very important retrieve specimen allow for subsequent pathological evaluation; however, retrieval difficult larger than cm. Wu et al. successfully applied balloon-assisted removal large...
Abstract Integrated analyses of hematopoiesis and leukemogenesis could provide new biological clinical insights 1,2 . Here we constructed a comprehensive cell atlas using ∼100,000 single transcriptomes bone marrow mononuclear cells its subsets from 5 healthy samples 13 leukemia samples. Trajectory analysis showed hematopoietic stem continuously differentiated through tree-like structure into 7 lineages. Although our the major cellular heterogeneity were inter-patients, there distinct...