A5103115350- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver physiology and pathology
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Autoimmune and Inflammatory Disorders
- Ocular Diseases and Behçet’s Syndrome
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Terahertz technology and applications
- Sulfur Compounds in Biology
- Digestive system and related health
- Cerebral Palsy and Movement Disorders
- Drug-Induced Hepatotoxicity and Protection
- IgG4-Related and Inflammatory Diseases
- Systemic Lupus Erythematosus Research
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- Ion Transport and Channel Regulation
- TGF-β signaling in diseases
Army Medical University
2018-2024
Southwest Hospital
2018-2024
Lingnan Normal University
2022
Xiamen University
2022
First Affiliated Hospital of Dalian Medical University
2015-2021
Dalian Medical University
2015-2021
Creative Commons
2020
Hunan University
2017
State Key Laboratory of Chemobiosensing and Chemometrics
2017
Nanomed (Brazil)
2017
Abstract Cholangiocytes play a crucial role in bile formation. Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of PBC remains unclear despite being characterized as an autoimmune disease. Using single-cell RNA sequencing (scRNA-seq), fluorescence-activated-cell-sorting, multiplex immunofluorescence (IF) and RNAscope analyses, we identified unique DUOX2 + ACE2 small cholangiocytes human mouse livers. Their selective decrease patients...
Background and Aims: Bile acids trigger a hepatic inflammatory response, causing cholestatic liver injury. Runt-related transcription factor-1 (RUNX1), primarily known as master modulator in hematopoiesis, plays pivotal role mediating responses. However, RUNX1 hepatocytes is poorly characterized, its cholestasis unclear. Herein, we aimed to investigate the of underlying mechanisms cholestasis. Approach Results: Hepatic expression was examined patients mouse models. Mice with liver-specific...
Abstract Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in diverse range immune responses via its receptor integrin β1. Recently, we reported that SEMA7A R148W mutation (a gain-of-function mutation, Sema7a R145W mice) is risk factor for progressive familial intrahepatic cholestasis and nonalcoholic fatty liver disease upregulated membrane localization. In this study, demonstrated β1 nuclear NF-kappa-B p105 (NF-κB p105) critical mediator...
Background and Aims: Inflammatory response is crucial for bile acid (BA)-induced cholestatic liver injury, but molecular mechanisms remain to be elucidated. Solute Carrier Family 35 Member C1 (SLC35C1) can transport Guanosine diphosphate-fucose into the Golgi facilitate protein glycosylation. Its mutation leads deficiency of leukocyte adhesion enhances inflammation in humans. However, little known about its role diseases. Approach Results: Hepatic SLC35C1 mRNA transcripts expression were...
Genetic polymorphisms are associated with the development of nonalcoholic fatty liver disease (NAFLD). Semaphorin7a (Sema7a) deficiency in mouse peritoneal macrophages reduces acid (FA) oxidation. Here, we identified 17 individuals SEMA7A heterozygous mutations 470 patients biopsy-proven NAFLD. increased susceptibility to NAFLD, steatosis severity, and NAFLD activity scores humans mice. The Sema7aR145W mutation (equivalent human SEMA7AR148W) significantly induced small lipid droplet...
A commercially available fluorescent hydrogen sulfide (H<sub>2</sub>S) probe 7-azido-4-methylcoumarin (AzMC) was developed into its lysosome-targeted counterpart Lyso-C<italic>via</italic>a four-step synthetic approach.
Yi Guan Jian decoction (YGD) may induce the differentiation of bone marrow mesenchymal stem cells (BMSCs) into hepatocyte-like (HLCs); however, underlying mechanisms remain to be elucidated. The present study aimed investigate this process. To do this, a dimethylnitrosamine (DMN)-induced liver cirrhosis mouse model was established. mice from group were randomly divided three subgroups: i) Negative control, ii) hepatocyte growth factor and iii) YGD. overall health, function histological...
Cholestasis is a common condition in which the flow of bile from liver to intestines inhibited. It has been shown that organic anion-transporting polypeptide 3A1 (OATP3A1) upregulated cholestasis promote acid efflux transport. We have previously growth factor fibroblast 19 and inflammatory mediator tumor necrosis α (TNFα) increased OATP3A1 mRNA levels hepatoma peritoneal lavage cell/PRF/5 cell lines. However, mechanism underlying TNFα-stimulated expression unknown. To address this, we...
Summary Background In the large randomised NEPTUNE study, peginterferon alfa‐2a 180 μg/wk for 48 weeks produced higher hepatitis B e antigen ( HB eAg) seroconversion rates 24 post‐treatment (36%) than a lower dose (90 μg/wk) and/or shorter duration (24 weeks) (range 14%‐26%). Aim To determine 5 years after completion of treatment in . Methods eAg‐positive patients who completed weeks’ follow‐up (with 90 × [group 1]; [2]; [3] or [4]) were followed up. Results Three hundred and eighty three...
Abstract In this study, fish marine bioactive peptides (FMBP) from gill waste obtained Tilapia ( Oreochromis mossambicus ) and bighead carp Hypophthalmichthys nobilis were explored to provide a green preservation method maintain the taste flavor of Chinese moon cake. FMBP hydrolyzed using mixture protease (neutral protease: alkaline = 1:1). The enzymatic reaction conditions researched by single‐factor experiments with antibacterial activity as evaluation index. Moon cakes treated coating...
The effects of probiotics Lactobacillus plantarum GMNL-662 (Lp662) and 299v (Lp299v) treatment on severe inflammatory bowel disease induced by dextran sodium sulfate was assessed. Male C57BL/6J mice (6 weeks old) were administered 0.9% NaCl, Lp662, or Lp299v gavage during the entire experiment. After 3 weeks, gut inflammation associated with bone loss, compared to control group, weight loss caused colitis in Lp662 groups decreased (P < 0.001). Pathological sections colon showed that reduced...
Advanced fibrosis is a crucial stage in the progression of autoimmune hepatitis (AIH), where can either regress or advance. This study aims to leverage machine learning (ML) models for assessment advanced liver AIH patients using routine clinical features. A total 233 diagnosed with and underwent biopsy were included discovery cohort. The dataset was randomly split into training testing sets. Patients categorized groups no/minimal/moderate fibrosis. Six ML employed identify optimal model....
Seeing that about 70% component of fresh biological tissues is water, many scientists try to use water models describe the dielectric properties tissues. The classical are Debye model, Double model and Cole-Cole model. This work aims determine a suitable by comparing three above with experimental data. These applied pork tissue. By means least square method, parameters different fitted Comparing on both function, verified best experiments correction factor α an important modification for So...