A5101673334- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Prostate Cancer Treatment and Research
- Thyroid Disorders and Treatments
- Nanoplatforms for cancer theranostics
- Pituitary Gland Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Medical Imaging Techniques and Applications
- Complement system in diseases
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Exercise and Physiological Responses
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Liver Diseases and Immunity
- Delphi Technique in Research
- Signaling Pathways in Disease
Erasmus MC
2013-2025
Erasmus MC Cancer Institute
2022-2023
Erasmus University Rotterdam
2004-2021
Amsterdam University Medical Centers
2019
University Medical Center Utrecht
2015
Bicêtre Hospital
2013
Radboud University Nijmegen
1981-2010
Mallinckrodt (United States)
2007
Rotterdam University of Applied Sciences
1993-2006
Amsterdam UMC Location University of Amsterdam
2003
We recently introduced the potent gastrin-releasing peptide receptor (GRPR) antagonist <sup>68</sup>Ga-SB3 (<sup>68</sup>Ga-DOTA-<i>p</i>-aminomethylaniline-diglycolic acid-DPhe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt), showing excellent tumor localizing efficacy in animal models and patients. By replacement of C-terminal Leu<sup>13</sup>-Met<sup>14</sup>-NH<sub>2</sub> dipeptide SB3 by Sta<sup>13</sup>-Leu<sup>14</sup>-NH<sub>2</sub>, novel GRPR NeoBOMB1 was generated labeled with different...
Male Wistar rats were treated with 50 mg 3,3',4,4'-tetrachlorobiphenyl (TCB)/kg BW or vehicle. After 4 days, the livers isolated and perfused for 90 min 2 nM [125I]T3 10 [125I]T4 in Krebs-Ringer medium containing 1% albumin. Deiodination conjugation products remaining substrates determined bile samples by Sephadex LH-20 chromatography HPLC. TCB treatment did not affect hepatic uptake metabolism of T3. However, biliary excretion T4 glucuronide was strongly increased TCB, resulting an...
We compared the internalization of [90Y-DOTA0,Tyr3]octreotide and [111In-DOTA0,Tyr3]octreotide with that [125I-Tyr3]octreotide [111In-DTPA0]octreotide in subtype 2 somatostatin receptor (sst2)-positive rat pancreatic tumour cell lines Ca20948 AR42) receptor-negative human anaplastic thyroid line ARO. demonstrated [111In-DTPA0]octreotide, are internalized by a receptor-specific, time- temperature-dependent process. The amount was higher than [111In-DTPA0]octreotide.
Abstract Purpose: The somatostatin analogue [DOTA0, Tyr3]octreotide (DOTATOC) has previously been labeled with low linear energy transfer (LET) β-emitters, such as 177Lu or 90Y, for tumor therapy. In this study, DOTATOC the high-LET α-emitter, 213Bi, was evaluated. Experimental Design: radiolabeling, stability, biodistribution, toxicity, safety, and therapeutic efficacy of 213Bi-DOTATOC (specific activity 7.4 MBq/μg) were investigated. Biodistribution studies to determine receptor...
Abstract Introduction Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure compressive forces. Moderate physical exercise known improve content and might protect against osteoarthritis (OA). This study investigated whether rat knee joints with depleted articular through papain injections benefit from moderate exercise, or this increases the susceptibility for degeneration....
A single tool for early detection, accurate staging, and personalized treatment of prostate cancer (PCa) would be a major breakthrough in the field PCa. Gastrin-releasing peptide receptor (GRPR) targeting peptides are promising probes theranostic approach PCa overexpressing GRPR. However, successful application small is often hampered by their fast vivo degradation proteolytic enzymes, such as neutral endopeptidase (NEP). Here we show first time that co-injection NEP inhibitor...
Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation known be facilitated by synovial macrophage activation. injections might influence activation subsequently osteophytosis. Although widely applied in clinical care, the mechanism through which exerts this effect remains unknown. In animal study, we investigated vivo effects of on activation, development joint...
Bombesin is a tetradecapeptide neurohormone that binds to gastrin-releasing peptide receptors (GRPR). GRPRs have been found in variety of cancers including invasive breast and prostate tumors. The MP2346 (DOTA−(Pro1,Tyr4)-bombesin(1−14)) was designed bind these GRP receptors. This study undertaken evaluate radiolabeled as positron emission tomography (PET) imaging agent. radiolabeled, high radiochemical purity, with the positron-emitting nuclides 64Cu (t1/2 = 12.7 h, β+ 19.3%, Eavg 278 keV)...
Bombesin (BN) is a 14-amino-acid neuropeptide with high affinity for the gastrin-releasing peptide receptor. This receptor has been found to be expressed in variety of tumours, including lung, breast, prostate and pancreas. A newly synthesized BN analogue, [DTPA-Pro1,Tyr4]BN, was shown high-affinity BN-receptor (BNR) agonist, stimulating prolactin secretion from 7315b cells an IC50 8 nM. The 111In-labelled analogue bind rat BNR vitro vivo. radioligand internalized by BNR-expressing cells,...