A5101489843- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Peroxisome Proliferator-Activated Receptors
- Bone and Joint Diseases
- Cardiovascular Disease and Adiposity
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Inflammatory mediators and NSAID effects
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience of respiration and sleep
- Bone fractures and treatments
- Fatty Acid Research and Health
- HIV-related health complications and treatments
- Neuroscience and Neural Engineering
- Immune Response and Inflammation
- Cardiac Arrhythmias and Treatments
- Mesenchymal stem cell research
- Anesthesia and Neurotoxicity Research
- Veterinary Equine Medical Research
- Cephalopods and Marine Biology
- Pregnancy and Medication Impact
- Adipose Tissue and Metabolism
- Ocular and Laser Science Research
Erasmus MC
2012-2022
Elisabeth-TweeSteden Ziekenhuis
2022
Erasmus University Rotterdam
2012-2017
Capital Medical University
2011-2013
Beijing Anzhen Hospital
2013
Xijing Hospital
1991
U.S. Energy Information Administration
1989
Copiah-Lincoln Community College
1985
Objective Stiffening of the joint is a feature knee osteoarthritis (OA) that can be caused by fibrosis synovium. The infrapatellar fat pad (IPFP) present in produces immune‐modulatory and angiogenic factors. goal study was to investigate whether IPFP influence fibrotic processes synovial fibroblasts, determine role transforming growth factor β (TGFβ) prostaglandin F 2α (PGF ) these processes. Methods Batches fat‐conditioned medium (FCM) were made culturing pieces obtained from knees 13...
Triamcinolone acetonide (TA) is used for osteoarthritis management to reduce pain, and pre-clinical studies have shown that TA limits osteophyte formation. Osteophyte formation known be facilitated by synovial macrophage activation. injections might influence activation subsequently osteophytosis. Although widely applied in clinical care, the mechanism through which exerts this effect remains unknown. In animal study, we investigated vivo effects of on activation, development joint...
Free fatty acids (FAs) may influence cartilage metabolism and osteoarthritis (OA) disease progression. It is not clearly studied which FAs are present in the synovial fluid of knee joints whether there differences FA content between nonsymptomatic OA joints. The aim this study was to investigate presence different types both OA- control joints, analyze groups.A total 23 samples were collected from patients with end-stage undergoing replacement, approval medical ethical committee. As...
Obesity is associated with the development and progression of osteoarthritis (OA). Although infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization knee joint, there currently little known about effect obesity on IFP. Therefore, we investigated cellular molecular body mass index (BMI)-related features IFP OA patients.Patients (N = 155, 68% women, mean age 65 years, (SD) BMI 29.9 kg/m2 (5.7)) were recruited: volume was determined by magnetic...
Cartilage repair by bone marrow derived mesenchymal stem cells (MSCs) can be influenced inflammation in the knee. Next to synovium, infrapatellar fat pad (IPFP) has been described as a source for inflammatory factors. Here, we investigated whether factors secreted IPFP affect chondrogenesis of MSCs and this is different joint pathologies or obesity. Furthermore, examined role resident macrophages. First, made conditioned medium from obtained osteoarthritic joints, traumatically injured...
Cartilage defects result in joint inflammation. The presence of proinflammatory factors has been described to negatively affect cartilage formation.To evaluate the effect and timing administration triamcinolone acetonide (TAA), an anti-inflammatory drug, on repair using a mouse model.Controlled laboratory study.A full-thickness defect was created trochlear groove 10-week-old male DBA/1 mice (N = 80). Mice received intra-articular injection TAA or saline day 1 7 after induction defect. were...
Obesity is a well-known risk factor for osteoarthritis, but it unknown what does on cartilage repair. Here we investigated whether high fat diet (HFD) influences repair in mouse model of We fed DBA/1 mice control or HFD (60% energy from fat). After 2 weeks, full thickness defect was made the trochlear groove. Mice were sacrificed, 1, 8, and 24 weeks after operation. Cartilage evaluated histology. Serum glucose, insulin amyloid A measured h before operation at endpoints. Immunohistochemical...
<h3>Objective</h3> There are multiple echocardiographic abnormalities in the geriatric population, whether number of could possibly affect NT-proBNP levels. The aim this study was to assess association between and levels inpatients. <h3>Method</h3> A total 148 subjects aged 60 years or over were recruited. Plasma N-terminal proBNP measured by ELISA. Echocardiography left atrial diameter, ventricular valvular lesions, wall motion, systolic diastolic function fibrillation so on. Inpatients...
<h3>Background</h3> Obesity is associated with the development and progression of osteoarthritis (OA). The infrapatellar fat pad (IFP) could contribute to this association due its localization in knee joint secretion inflammatory mediators. However, little known about effects obesity on IFP. Therefore, aim study was investigate presence obesity-related features adipocytes infiltrating immune cells IFP OA patients. <h3>Materials methods</h3> volume determined by MRI 79 subcutaneous adipose...
<h3>Background</h3> Obesity is associated with the development and progression of osteoarthritis (OA), both for weight-bearing non-weight bearing joints. Several lines research indicate that obesity-related systemic factors, such as adipose tissue-derived could be involved in this association. The infrapatellar fat pad (IFP) an tissue depot localized knee joint. mediate obesity-associated effects. However, it currently unknown whether how obesity affects IFP. <h3>Objectives</h3> To...