A5083248973- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- High Altitude and Hypoxia
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced materials and composites
- Genetic Associations and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Titanium Alloys Microstructure and Properties
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
Soochow University
2025
Fudan University
2016-2024
Zhongshan Hospital
2023-2024
State Key Laboratory of Oncogene and Related Genes
2024
Shanghai Jiao Tong University
2020-2024
Simcere Pharmaceutical (China)
2023
Ningxia Medical University
2023
Shaanxi Normal University
2021-2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
Long non‐coding RNAs (lncRNAs) have been identified to play vital roles in cancers, including human retinoblastoma (RB). However, the deepgoing mechanism is still ambiguous. In present study, we investigate biological role of lncRNA DANCR (differentiation antagonizing non‐protein coding RNA) carcinogenesis RB. Results revealed that was up‐regulated RB tissue and cell lines. Moreover, ectopic overexpression indicated poor overall survivals disease free survival (DFS) for patients. vitro vivo...
Abstract Due to the tolerance of mismatches between gRNA and targeting sequence, base editors frequently induce unwanted Cas9-dependent off-target mutations. Here, develop models predict such off-targets, we design gRNA-off- target pairs for adenine (ABEs) cytosine (CBEs) stably integrate them into human cells. After five days editing, obtain valid efficiency datasets 54,663 55,727 off-targets ABEs CBEs, respectively. We use train deep learning models, resulting in ABEdeepoff CBEdeepoff,...
Abstract DNA methylation plays a pivotal role in the development and progression of tumors. However, studies focused on dynamic changes hepatocellular carcinoma (HCC) are rare. To systematically illustrate alternation from premalignant to early-stage liver cancer with same genetic background, this study enrolled 5 HBV-related patients preceded cirrhosis, pathologically identified as HCC dysplastic nodules. Liver fibrosis tissues, nodules early tissues these were used measure methylation....
Unmet supportive care needs reducing the quality of life colorectal cancer (CRC) patients. As existing studies have indicated CRC patients different genders differ, main aim this study was to investigate factors influencing based on gender. were categorized by gender compare each group's and demographic characteristics. Multiple linear regression analysis employed identify impacting The involved 257 males 146 females Female reported higher levels needs. Among male patients, those with...
Uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity. Metastatic uveal samples frequently exhibit monosomy 3 or BAP1 deficiency. In this study, we used bioinformatic methods to investigate the immune infiltration of in public datasets. We first performed Gene Set Enrichment/Variation Analyses detect immunological pathways are altered tumors with then conducted unsupervised clustering analysis identify distinct immunologic molecular subtypes melanoma....
This study was aimed at investigating the differentially expressions of long noncoding RNAs (lncRNAs) and mRNAs in brains a middle cerebral artery occlusion/reperfusion (MCAO/R) group MCAO/R + 20(R)-Rg3 group. Biological enrichment analysis performed, lncRNA-mRNA coexpression network constructed, to reveal targets pathways involved regulation ischemia-reperfusion injury (CIRI). The RNA-seq high-throughput sequencing method employed detect differentially-expressed genes between groups, which...
PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of primary hepatocellular carcinoma a Southern Chinese Zhuang population. We assessed global messenger RNA expression patients with using The Cancer Genome Atlas dataset. Increased expression, related to alpha-fetoprotein level, was observed. area under receiver operating characteristic curve value 0.833. Kaplan–Meier...
Asthma is a common, complex disease with apparent genetic predispositions, and previous genome-wide association studies suggest that rs1295686 within the IL13 (IL-13) gene significantly associated asthma. Analysis of data provided by 1,000 Genomes Project indicated an additional four SNPs in nearly complete linkage disequilibrium White people. However, causal mechanism remain unclear. To investigate this issue, functional genomics approaches were utilized to analyze functions these SNPs....
Breast cancer ranks as the most frequently diagnosed among women worldwide.Elevated cytoplasmic p21 levels are often found in breast tissues and related to a poor prognosis.However, underlying mechanisms that lead stabilization of protein, which normally has very short half-life, remain obscure.In this study, we there was strong correlation between USP11 cytoplasm cells.Furthermore, revealed ERK1/2 phosphorylated at Ser905 site, promoted localization USP11.In cytoplasm, colocalized...
Abstract Objective This study aimed to investigate the safety and efficacy of computed tomography (CT)-guided hook-wire localization technique in thoracoscopic surgery for small pulmonary nodules (≤ 10 mm) identify risk factors localization-related complications. Methods The medical records 150 patients with treated from January 2018 June 2021 were retrospectively analyzed. According preoperative positioning status, they divided into group (50 cases) or control (100 cases). operation time,...
Gas chromatography-mass spectrometry (GC-MS) is an analytical technique widely used in materials science, biomedicine, and other fields. The target compound the experiment identified by searching for its mass spectrum a large database using some algorithms. This work introduces use of deep learning ranking identification small molecules low-resolution electron ionization MS. Because different spectra are often very similar, algorithm produces wrong search results, accuracy needs improvement....
In recent years, lots of studies have reported the relationship between genetic variation or expression and cancer prognosis with radiotherapy-based treatment. However, due to limitation in available journals literature database, inconsistent nomenclature system time-consuming investigation on searching reading, considerable researches could hardly get found cited. this study, we constructed Radiotherapy Prognosis Database (RTPDB), which contains a comprehensive resource about genes related...
N7-Methylguanosine (m7G) is an RNA modification serving as a key part of colon cancer development. Thus, comprehensive analysis was executed to explore prognostic roles and associations with the immune status m7G-related lncRNA (m7G-RNAs) in adenocarcinoma (COAD). Identification m7G-RNAs achieved via Pearson's correlation lncRNAs TCGA-COAD dataset m7G regulators. A signature developed LASSO analyses. ESTIMATE, CIBERSORT, ssGSEA algorithms were utilized assess infiltration between different...
3-input AND/XOR is the basic complex gate of Reed-Muller logic. Low energy consumption important for logic circuit implementation. Against drawbacks published gate-level and transistor-level design in power delay product (PDP), a low proposed by employing multi-rails hybrid-CMOS techniques to improve its speed short signal transimission path. Under 55nm CMOS process, post-simulations different process corners are carried out using HSPICE compared with circuits. Simulation results show that...