A5100339129- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Innovative Teaching Methods
- Evaluation Methods in Various Fields
- Autophagy in Disease and Therapy
- Nuts composition and effects
- Evaluation and Optimization Models
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health and Wellbeing Research
- Lipid metabolism and disorders
- Carcinogens and Genotoxicity Assessment
- Cell death mechanisms and regulation
- Enzyme function and inhibition
- Pregnancy and preeclampsia studies
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
China Pharmaceutical University
2024
First Hospital of Lanzhou University
2018-2023
Lanzhou University
2018-2023
Beijing Luhe Hospital Affiliated to Capital Medical University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
Northeast Agricultural University
2022
Zhengzhou University
2021
Xuzhou Medical College
2020
The long noncoding RNA (lncRNA) JPX is a molecular switch for X-chromosome inactivation. Accumulating studies have shown that the aberrant expression and function of lncRNAs are involved in occurrence development tumors. However, functional importance mechanism action lncRNA cervical cancer (CC) remain unknown.In this study, qRT-PCR western blotting were used to evaluate mRNA or protein JPX, miR-25-3p SOX4 CC tissues cell lines. StarBase v2.0 database, luciferase reporter assay...
Background.Gestational diabetes mellitus (GDM) severely threatens maternal and fetal health.Long noncoding RNA (lncRNA) participates in the regulation of various cellular processes.Objectives.Previous studies have identified role lncRNA MALAT1 diabetic retinopathy-related inflammation.However, GDM has not been reported yet.Material methods.Real-time polymerase chain reaction (RT-PCR) was used to measure expression level placental tissues from patients a normal pregnant group.Placental...
Abstract Hepatic steatosis is characterised by excessive triglyceride accumulation in the form of lipid droplets (LD); however, mechanisms differ drug induced (DIS) and/or non-alcoholic fatty liver disease (NAFLD). Here we hypothesized distinct molecular circuits microRNA/LD-associated target genes and searched for mechanistically linked serum tissue biomarkers that would distinguish between DIS human NAFLD different grades. We analysed >800 rat hepatic whole genome data 17 steatotic...
MicroRNAs (miRNAs) are key post-transcriptional regulators that affect protein translation by targeting mRNAs. Their role in disease etiology and toxicity well recognized. Given the rapid advancement of next-generation sequencing techniques, miRNA profiling has been increasingly conducted with RNA-seq, namely miRNA-seq. Analysis miRNA-seq data requires several steps: (1) mapping reads to miRBase, (2) considering mismatches during hairpin alignment (windowing), (3) counting (quantification)....
The long non-coding (lnc)RNA B-Raf proto-oncogene, serine/threonine kinase-activated non-protein coding RNA (BANCR) is a well-characterized oncogene, while its potential functions in other diseases remain elusive. In the present study, possible association of BANCR with diabetic retinopathy was investigated. A total 244 patients diabetes were followed up every 6 months for 8 years to record occurrence retinopathy. 38 developed During follow-up, plasma levels lncRNA decreased those but not...
Background: Abnormal glucose and lipid metabolism plays a critical role in gastric carcinogenesis development. Hence, we presented systematic analysis of metabolism-related genes to explore their function prognostic value cancer (GC). Methods: The consensus clustering algorithm was used identify the molecular subtypes based on genes. Subsequently, cox regression lasso were utilized establish risk prediction model. A clinical nomogram constructed assist prognosis assessment. In addition,...
Abstract Osteosarcoma (OS) is the most prevalent malignant bone tumor with poor prognosis. Developing new drugs for chemotherapy of OS has been a focal point and major obstacle treatment. Nitazoxanide (NTZ), conventional anti-parasitic agent, got increasingly noticed because its favorable antitumor potential. Herein, we investigated effect NTZ on human cells in vitro vivo . The results obtained showed that inhibited proliferation, migration invasion, arrested cell cycle at G1 phase, while...
Gastric cancer (GC) is one of the common gastrointestinal malignancy worldwide and exhibits a poor prognosis. Increasing studies have indicated that microRNAs play critical roles in progression shown great potential as useful biomarkers. The search for diagnostic prognostic biomarkers gastric with integrated bioinformatics analyses has been undertaken previous studies.In this study, robust rank aggregation (RRA) method was used to perform an analysis differentially expressed miRNAs (DEMs)...
Approximately half of the world's gastric cancer cases and deaths occur in China. In addition, incidence mortality rates Gansu province China are much higher than average nationwide levels. The present study investigated microRNA (miRNA/miR) profiles early (EGC) without specific symptoms. miRNA expression levels five pairs EGC tissues adjacent non‑cancerous mucosa patients from were analyzed using a microarray. A total 47 differentially expressed miRNAs (DEMs) identified. Subsequently, mRNA...
We explored the mediating role of social adaptation in relationship between mindfulness and cell phone dependence among college students. Data were obtained from 937 students, who completed Smartphone Addiction Inventory, Adolescent Mindfulness Measure, Social Adaptation Questionnaire. The results suggest that significantly negatively correlated with dependence, level students had a significant direct predictive effect on their dependence. also found These findings are significance to...
Ermiao wan (EMW) is a classical traditional Chinese medicine formula, with two modified versions including Sanmiao (SMW) and Simiao (FMW). These categorized formulas (ECFs) are traditionally used to treat gouty arthritis hyperuricemia. However, their potential benefits mechanisms on diabetes remain be explored. This study aims investigate the overall effects biological differences of ECFs in high fat diet (HFD)-fed mice based network pharmacology transcriptomics. significantly reduced body...
The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. discovery novel valuable biomarkers for the early diagnosis therapeutic guidance HCC urgently needed.Extracellular matrix (ECM)-related gene sets, transcriptome data mutation profiles were downloaded from Matrisome Project Cancer Genome Atlas (TCGA)-LIHC datasets. Coexpression analysis was initially performed with aim identifying ECM-related lncRNAs (r > 0.4, p < 0.001)....
Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and its pathophysiological mechanisms remain unknown. IRSp53 family members, such as BAIAP2L1, participate in the progression multiple tumors. However, role BAIAP2L2 HCC remains unclear. This study comprehensively analyzed potential using bioinformatic techniques. The expression was Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), International Consortium (ICGC), Human Protein (HPA)...
Environmental chemicals exposure is one of the primary factors for liver toxicity and hepatocarcinoma. Thioacetamide (TAA) a well-known hepatotoxicant could be carcinogen in humans. The discovery early sensitive microRNA (miRNA) biomarkers injury tumor progression improve cancer diagnosis, prognosis, management. To study this, we performed next generation sequencing livers Sprague-Dawley rats treated with TAA at three doses (4.5, 15 45 mg/kg) four time points (3-, 7-, 14- 28-days). Overall,...
Background/Aims: Ovarian cancer (OC) causes more death and serious conditions than any other female reproductive cancers, many expression signatures have been identified for OC prognoses. However, no significant overlap is found among from different studies, indicating the necessity of signature identifications at functional level. Methods: We performed an integrated analyses miRNA gene expressions to identify prognostic subpathways (pathway regions). Using The Cancer Genome Atlas data set,...
UCA1 is predicted to bind miR-132, which a key player in the proliferation of vascular smooth muscle cells (VSMCs). This research studied role lncRNA atherosclerosis. The binding miR-132 was proved by dual luciferase activity assay and RNA immunoprecipitation. failed affect each other's expression VSMCs. upregulated decreased atherosclerosis plasma. However, they are not closely correlated across control plasma sample. Interestingly, suppressed downregulating Lrrfip1 promoting VSMC...
This paper explores the course design and student satisfaction with a Chinese university basketball offered in blended mode through support of mobile technology. There are four parts to this study: (1) using learning approach supported by flipped classrooms app; (2) 3-week trial as pilot study spring semester 2017; (3) informed study, semester-long implementation autumn (4) an evaluation students' use surveys. The results indicate that delivery effectively facilitated learning. survey data...
Different matrisomal patterns are shared across carcinomas. However, little is known about whether there exists a unique tumor matrisome that modulates GC progression and immune regulation. We conducted genome-wide analysis based on matrisomal-related lncRNAs (MRLs) in 375 patients with from the Cancer Genome Atlas (TCGA) database. Patients were split into training set validation at ratio of 1:1 using R package cart. Pearson correlation (PCA) was performed to identify correlated differential...
Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer in world with high incidence rate and poor prognosis. Infiltrated immune stromal cells are vital components tumor microenvironment (TME) have a significant impact on progression ESCC. The competitive endogenous RNA (ceRNA) hypothesis has been proved important molecular biological mechanisms development. However, there few studies relationship between ceRNA ESCC TME.The proportion...