A5023873863- Aluminum toxicity and tolerance in plants and animals
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Mycotoxins in Agriculture and Food
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Effects and risks of endocrine disrupting chemicals
- Curcumin's Biomedical Applications
- Sperm and Testicular Function
- Cell death mechanisms and regulation
- Microplastics and Plastic Pollution
- Selenium in Biological Systems
- Plant and fungal interactions
- Bone Metabolism and Diseases
- Advanced Glycation End Products research
- Biochemical Acid Research Studies
- Magnesium in Health and Disease
- Digestive system and related health
- Restraint-Related Deaths
- Mitochondrial Function and Pathology
- Toxin Mechanisms and Immunotoxins
- Genital Health and Disease
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
Minzu University of China
2023-2024
Northeast Agricultural University
2020-2023
Inner Mongolia University for Nationalities
2022
T-2 toxin is an inevitable mycotoxin in food products and feeds. It a proven toxicant impairing the male reproductive system. However, previous studies have concentrated on toxic effect of Leydig cells, with little attention Sertoli cell cytotoxicity. Therefore, this study aimed to establish mechanism cells. The line (TM4 cell) was cultured exposed different concentrations with/without N-acetyl-L-cysteine (NAC) for 24 h. A CCK-8 assay then measured viability. In addition, expression TM4...
Aflatoxin B1 (AFB1) is a serious pollutant in feed and food which causes liver inflammation, fibrosis, even cirrhosis. The Janus kinase 2 (JAK2)/signal transducers activators of the transcription 3 (STAT3) signaling pathway widely involved inflammatory response promotes activation nod-like receptor protein (NLRP3) inflammasome, thus leading to pyroptosis fibrosis. Curcumin natural compound with anti-inflammatory anti-cancer properties. However, whether AFB1 exposure leads JAK2/NLRP3 curcumin...
Aflatoxin B1 (AFB1) is an extremely hazardous and unavoidable pollutant for cereals feedstuff. AFB1 can cause testicular lesion, how to alleviate its toxicity has received much attention in recent years. Lycopene (LYC), a foodborne nutrient derived from red fruits vegetables, protective effects against sperm abnormality lesions. To confirm the beneficial effects mechanisms of LYC on AFB1-induced 48 male mice were exposed 0.75 mg/kg or/and 5 consecutive 30 days. Results demonstrated...
The worldwide prevalence of Aflatoxin B1 (AFB1), which contaminates feedstock and food, is on the rise. AFB1 inhibits testosterone (T) biosynthesis, but mechanism not yet clear. By establishing in vivo vitro models, this study found number Leydig cells (LCs), T content, expression biosynthesis key enzymes were suppressed after treatment. exposure also increased reactive oxygen species (ROS) promoted mitochondrial injury pathway apoptosis. Moreover, AMPK signaling was activated, using an...
T-2 toxin treatment causes male reproduction system dysfunction, although the exact mechanism remains unclear. In this research, Kunming mice and TM4 cells were treated with varying concentrations of for evaluating adverse effect on reproductive function. MCC950 or NAC was used to block NLRP3 inflammasome activation eliminate reactive oxygen species (ROS) accumulation in cell, respectively. The results showed that: (1) caused testicular atrophy, destroyed microstructure ultrastructure...
The pollution of aluminum (Al) in agricultural production and its wide application food processing greatly increase the chance human animal exposure. Al can accumulate bone cause diseases by inducing oxidative stress. Mitophagy maintain normal cell function degrading damaged mitochondria scavenging reactive oxygen species. However, role mitophagy impairment caused is unknown. In this study, we demonstrated that PTEN induced putative kinase 1 (PINK1)/ E3 ubiquitin ligase PARK2...
T-2 toxin causes kidney fibrosis. Wnt/β-catenin signaling promotes fibrosis when sustained and activated. However, whether T-2-induced involves activation has not been explored yet. renal mitochondrial damage, leading to reactive oxygen species (mtROS) overproduction NLRP3-inflammasome activation. The activated can mediate the be mediated by mtROS further regulate through is unclear. In this study, first, we confirmed that caused in mice kidneys HK-2 cells. Second, T-2-exposed Third,...
T-2 toxin is one of the most common mycotoxins found in grain foods, animal feed, and other agricultural by-products causing food contamination health threat. The skeletal system main target tissue for toxin. exposure also recognized as a potential contributor to multiple types bone diseases, including Kashin-Beck disease. However, mechanisms toxin-induced toxicity remain unclear. In this study, 60 male C57BL/6 mice were exposed with 0, 0.5, 1 or 2 mg/kg body weight by intragastric...
Dibutyl phthalate (DBP) is a plasticizer widely used in daily production, which causes serious environmental pollution, and damage to brain, liver, kidney, lung by producing excessive reactive oxygen species (ROS) after entering the body. DBP can also cause skeletal dysplasia, but it unclear whether ROS involved. In addition, overproduction of activate mitophagy, an important mechanism for regulating mitochondrial quality cell homeostasis. order investigate MC3T3-E1 cells (osteoblast line)...
Aluminum (Al)-induced bone formation and metabolism disorder through inhibition of the TGF-β1/Smad signaling pathway is one important mechanisms impairment. Ginsenoside Rg3 (Rg3), a specific biological effector molecule, can provide protection to bones. Previously, we demonstrated that reverse aluminum chloride (AlCl3)-induced oxidative stress metabolic bones; however, whether involved in it remains unclear. First, found attenuated Al-induced impairment vivo vitro by relieving structural...