A5056448383- Aluminum toxicity and tolerance in plants and animals
- Selenium in Biological Systems
- Mycotoxins in Agriculture and Food
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Connexins and lens biology
- Sperm and Testicular Function
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Plant Toxicity and Pharmacological Properties
- Alzheimer's disease research and treatments
- Carcinogens and Genotoxicity Assessment
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Rabbits: Nutrition, Reproduction, Health
- Magnesium in Health and Disease
- Insect and Pesticide Research
- Renal and related cancers
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Sesame and Sesamin Research
- Plant and fungal interactions
Anhui Agricultural University
2022-2024
Northeast Agricultural University
2015-2023
Aflatoxin B1 (AFB1) pollutes foodstuffs and feeds, causing a food safety problem seriously endangering human animal health. Liver is the principal organ for AFB1 accumulation biotransformation, during which can cause acute chronic liver damage, however, specific mechanism not completely clear. Mitochondria are primary organelle of cellular bio-oxidation, providing 95% energy to execute its multiple functions. Therefore, we speculated that mitochondrial dysfunction involved in AFB1-induced...
Aflatoxin B1 (AFB1) is an extremely hazardous and unavoidable pollutant for cereals feedstuff. AFB1 can cause testicular lesion, how to alleviate its toxicity has received much attention in recent years. Lycopene (LYC), a foodborne nutrient derived from red fruits vegetables, protective effects against sperm abnormality lesions. To confirm the beneficial effects mechanisms of LYC on AFB1-induced 48 male mice were exposed 0.75 mg/kg or/and 5 consecutive 30 days. Results demonstrated...
The worldwide prevalence of Aflatoxin B1 (AFB1), which contaminates feedstock and food, is on the rise. AFB1 inhibits testosterone (T) biosynthesis, but mechanism not yet clear. By establishing in vivo vitro models, this study found number Leydig cells (LCs), T content, expression biosynthesis key enzymes were suppressed after treatment. exposure also increased reactive oxygen species (ROS) promoted mitochondrial injury pathway apoptosis. Moreover, AMPK signaling was activated, using an...
The pollution of aluminum (Al) in agricultural production and its wide application food processing greatly increase the chance human animal exposure. Al can accumulate bone cause diseases by inducing oxidative stress. Mitophagy maintain normal cell function degrading damaged mitochondria scavenging reactive oxygen species. However, role mitophagy impairment caused is unknown. In this study, we demonstrated that PTEN induced putative kinase 1 (PINK1)/ E3 ubiquitin ligase PARK2...
Deoxynivalenol (DON) is widely present in cereals and processed grains. It can disrupt the blood-testicular barrier (BTB), leading to sterility males; however, mechanism unknown. In this study, 30 Kunming mice TM4 cells were exposed 0 or 4.8 mg/kg (28 d) 0–2.4 μM (24 h) of DON, respectively. Histopathological findings showed that DON increased BTB permeability mice, tight junction (TJ) structural damage. Immunofluorescence results indicated disrupted localization zonula occludens (ZO)-1. The...
Aflatoxin B
This study aimed to investigate the effects of zearalenone (ZEA) on piglet Sertoli cell (SC)-mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) based mitochondrial fission, and explore molecular mechanism ZEA-induced damage. After SCs were exposed ZEA, viability decreased, Ca2+ levels increased, MAM showed structural Moreover, glucose-regulated protein 75 (Grp75) Rho-GTPase 1 (Miro1) upregulated at mRNA levels. However, phosphofurin acidic cluster 2 (PACS2), mitofusin2...