A5052498017- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Health and Disease Prevention
- Aortic Thrombus and Embolism
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Stroke Rehabilitation and Recovery
- Clinical practice guidelines implementation
- Healthcare Systems and Practices
- EEG and Brain-Computer Interfaces
- Genetic Neurodegenerative Diseases
- Ocular Diseases and Behçet’s Syndrome
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- 3D Surveying and Cultural Heritage
- Cerebral Venous Sinus Thrombosis
- Oropharyngeal Anatomy and Pathologies
- Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Ocular Infections and Treatments
Kliniken Schmieder
2024
Klinikum Saarbrücken
2019
Heidelberg University
2008-2016
University Hospital Heidelberg
2008-2016
International Hellenic University
2014
University Medical Centre Mannheim
2008-2012
Centre for Movement Disorders
2012
Marymount University
2010
Transferring patients with large-vessel occlusion (LVO) or intracranial hemorrhage (ICH) to hospitals not providing interventional treatment options is an unresolved medical problem.To determine how optimized prehospital management (OPM) based on use of the Los Angeles Motor Scale (LAMS) compares in a Mobile Stroke Unit (MSU) accurately triaging appropriate hospital (comprehensive stroke center [CSC]) without (primary [PSC]) treatment.In this randomized multicenter trial 3-month follow-up,...
Zusammenfassung In der neuen S2k-Leitlinie „Erster epileptischer Anfall und Epilepsien im Erwachsenenalter“ werden Empfehlungen zu klinisch relevanten Fragestellungen in fünf großen Themenblöcken gegeben: Management erster Anfall, Pharmakotherapie, Epilepsiechirurgie, komplementäre supportive Therapieverfahren psychosoziale Aspekte. Beim Thema Leitlinie zunächst zur Unterscheidung beiden maßgeblichen Differenzialdiagnosen, Synkope psychogener nicht-epileptischer gegeben. Zudem wird...
<i>Background:</i> The etiology of ischemic strokes remains cryptogenic in about one third patients, even after extensive workup specialized centers. Atherosclerotic plaques the aorta can cause thromboembolic events but are often overlooked. They elude standard identification by transesophageal echocardiography (TEE), which is invasive or at best uncomfortable for many patients. CT angiography (CTA) be used as an alternative addition to TEE if this technique fails visualize every...
<i>Background:</i> Brain imaging in stroke aims at the detection of relevant ischemic tissue pathology. Cranial computed tomography (CT) is frequently used patients with transient attack (TIA) but no data available on how it directly compares to magnetic resonance (MRI). <i>Methods: </i>We compared acute lesions CT and MRI 215 consecutive TIA who underwent brain either (n = 161) or 54). An was performed within 24 h all had initially. <i>Results:</i>...
Purpose: Specialized electroencephalography (EEG) methods have been used to provide clues about stroke features and prognosis. However, the value of routine EEG in patients without (suspected) seizures has somewhat neglected. We aimed assess this a group acute ischemic regard short-term prognosis basic features. Methods: assessed (10–20) findings 69 consecutive seizures. Associations between abnormalities NIHSS scores, clinical improvement or deterioration as well MRI characteristics were...
We aimed to evaluate ictally-induced CSF parameter changes after seizures in adult patients without acute inflammatory diseases or infectious associated with the central nervous system. In total, 151 were included study. All admitted our department of neurology following and received an extensive work-up including EEG, cerebral imaging, examinations. protein elevation was found most (92; 60.9%) significantly older age, male sex, generalized seizures. Abnormal CSF-to-serum glucose ratio only...
Prognostic clinical scores (ABCD2 and ABCD3-I), as well specific signs symptoms (e.g. fluctuations) have been used to predict early stroke risk in patients admitted hospital after transient ischemic attacks (TIAs). We compared the utility of these for prognosis outcome.235 with TIAs our Comprehensive Stroke Center entered study. Patients were monitored over 3 days detailed brain imaging [diffusion-weighted (DWI) was performed either directly on admission or within 24 h from repeated cases...
<h3>Background and Objectives</h3> Whether physical activity (PA) is a risk factor for amyotrophic lateral sclerosis (ALS) controversial because data on lifelong PA are rare. The main objective of this study to provide insight into as potential ALS, reporting cumulative PA, leisure-time occupational PA. This also aims gather evidence the role prognostic in disease course. <h3>Methods</h3> Lifetime values collected by questionnaires addressing work leisure time were quantified metabolic...
<i>Background:</i> The management and risk of early stroke are unclear in patients with fluctuating neurological symptoms. We aimed to evaluate the clinical course these presenting within 24 h after onset acute cerebral ischemia <i>Methods:</i> All transient ischemic signs/symptoms consecutively admitted our Emergency Stroke Unit were recruited. Patients neurologically examined underwent prompt CCT plus MRI imaging for visualization signs ischemia....
Purpose To evaluate image quality and signal characteristics of brain perfusion CT (BPCT) obtained by low-dose (LD) ultra-low-dose (ULD) protocols with without post-processing highly constrained back-projection (HYPR)–local reconstruction (LR) technique. Methods Materials Simultaneous BPCTs were acquired in 8 patients on a dual-source-CT applying LD (80 kV,200 mAs,14×1.2 mm) tube A ULD kV,30 B. Image data from both tubes was reconstructed identical parameters post-processed using the...
Since many years, clinical decisions about the management of patients with carotid stenosis have been based on distinction between “asymptomatic” and “symptomatic” presentations. This was also reflected by design previous studies surgical versus conservative treatment current interventional surgery. Both terms, however, only address different phases activity one same condition blur significant message that is a most important marker systemic atherosclerosis, which accompanied much higher...
Large artery atherosclerosis (LAA) and small vessel disease (SVD) share common risk factors for stroke. We aimed at investigating the association of SVD with cerebral LAA as well in patients stroke likely to originate from aortic plaques.We investigated 71 consecutive (48 men, mean age 64.2 ± 13 years) ischemic undetermined cause according ASCO classification, who received ECG-triggered CT angiography best available atherosclerotic plaque detection aorta.Aortic plaques were detected 54...
We investigated the association of cerebral and coronary artery atherosclerosis with presence, burden type atherosclerotic plaques aorta (AP) in patients ischemic stroke undetermined etiology.48 consecutive (32 males, mean age 68 ± 11 years) acute unknown etiology after thorough workup were using ECG-gated CT-Angiography (CTA) for detection embolic AP. Intima media thickness (IMT), presence carotid stenosis ≥ 50% intracranial assessed as parameters atherosclerosis, Agatston score (AS) (CAS)...
The new S2k guideline "First epileptic seizure and epilepsies in adulthood" provides recommendations on clinically relevant issues five major topics: management of first seizures, pharmacotherapy, epilepsy surgery, complementary supportive treatment, psychosocial aspects. For the topic identifying two differential diagnoses, syncope psychogenic non-epileptic seizure. importance additional examinations such as EEG, MRI cerebrospinal fluid for syndromic classification etiological allocation is...
Patients with cardioembolic ischemic stroke from nonvalvular atrial fibrillation (NVAF) are candidates for long-term anticoagulation. This study examines the prevalence of cerebral microbleeds (MBs) in patients NVAF.A total 132 consecutive NVAF admitted to our Stroke Unit were recruited if complete magnetic resonance (MR) imaging studies including T2* had been performed within less than 72 hours. National Institutes Health Scale scores documented and cerebrovascular risk factors...