A5074945599- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Infant Development and Preterm Care
- Receptor Mechanisms and Signaling
- Retinopathy of Prematurity Studies
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- COVID-19 Impact on Reproduction
- Neonatal Health and Biochemistry
- Congenital Heart Disease Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital Diaphragmatic Hernia Studies
- Atomic and Subatomic Physics Research
- Pregnancy and preeclampsia studies
- Tracheal and airway disorders
- Thyroid Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Human Health and Disease
- Gestational Diabetes Research and Management
- Teratomas and Epidermoid Cysts
- Preterm Birth and Chorioamnionitis
Universität Innsbruck
2010-2025
Innsbruck Medical University
2013-2025
Medical University of Graz
2016
Neonatal inspiratory stridor is an important examination finding that requires immediate and adequate evaluation of the underlying etiology. Depending on severity airway obstruction presence or absence associated symptoms such as respiratory distress feeding problems, early initiation a complete diagnostic workup can be crucial. The most common cause neonatal laryngomalacia, however, several differential diagnoses need to investigated. More rare causes include oral laryngeal masses....
Cardiovascular disease is the leading cause of death worldwide. Evidence points towards an unfavorable cardiovascular risk profile former preterm infants in adolescence and adulthood. The aim this study was to determine whether predictors are detectable very at a preschool age. Five- seven-year-old children born <32 weeks' gestational age were included study. Same-aged term served as controls. Basic data participants collected by means follow-up databases standardized questionnaires. At...
To define percentile charts for arterial oxygen saturation (SpO
Introduction After the release of Bayley Scales Infant and Toddler Development, third edition (Bayley-III), US norms, an overestimation outcome was observed. But, conformity between second (BSID-II), Bayley-III German norms is unknown. This retrospective analysis aimed to compare outcomes very preterm infants tested with BSID-II norms. Methods Infants born from November 2007 July 2018 were included. Exclusion criteria death or missing outcome. underwent testing either until December 2013...
Introduction: Common brain injuries of preterm infants do not entirely explain the incidence neurodevelopmental impairment observed in this population. Evidence suggests an association with microstructural maturation splenium corpus callosum. This study aimed to investigate a correlation between callosum and outcome very infants. Method: In cohort 373 infants, we used fractional anisotropy (FA) apparent diffusion coefficient (ADC) derived from tensor imaging at term equivalent age (TEA)...
Introduction: Pregnant women are particularly susceptible to SARS-CoV-2 infection, which can provoke placental inflammation, potentially causing malperfusion and adverse pregnancy outcomes. The fetal immune system may respond maternal even without direct viral transmission. However, the molecular mechanisms driving these responses not well understood. This study aims examine changes in microRNA (miRNA) expression umbilical cord blood from neonates of mothers infected with during pregnancy....
Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim this study was characterize elastic properties aorta at preschool age and test hypothesis that prematurity is associated with decreased aortic distensibility increased stiffness, both which are predictors risk.In an observational 76 five- seven-year-old born a gestational <32 weeks 79 term-born controls, parameters ascending descending abdominal were determined noninvasively by means M mode...
<b><i>Introduction:</i></b> Perinatal asphyxia is a leading cause of neonatal death. Up to one-third asphyxiated neonates suffer from hypoxic-ischaemic encephalopathy (HIE) with substantial long-term morbidity. Currently available diagnostic and prognostic tools bear limitations, additional reliable biomarkers are needed for all stages clinical management. A novel tool in neuroscientific research micro-ribonucleic acid (miRNA) profiling. The aim the present study was...
Hypoxic-ischaemic encephalopathy is a major cause of neurologic impairment and mortality in neonates. Early knowledge brain injury important to guide therapeutic decisions reliably inform the parents. Increased secretoneurin levels have been detected adult patients suffering from it has also shown be promising early serum biomarker unfavourable neurological outcome. However, no data are available neonates.The aim this study was obtain reference values for healthy term neonates then assess...
Neurodevelopmental impairment is a significant complication among survivors of preterm birth. To improve outcomes, reliable biomarkers for early detection brain injury and prognostic assessment are required. Secretoneurin promising biomarker in adults full-term neonates suffering from perinatal asphyxia. Data on infants currently lacking. The aim this pilot study was to determine secretoneurin concentrations the neonatal period, assess secretoneurin’s potential as injury. We included 38 very...
Abstract Aim Measures to detect and monitor brain injury in preterm infants are amplitude‐integrated electroencephalography (aEEG) magnetic resonance imaging (MRI). To investigate the association between aEEG MRI a large cohort of infants. Five hundred twenty‐three were included study. Methods AEEG was interpreted for total maturation score (TMS) according Burdjalov. Cerebral evaluated using validated scoring system by Kidokoro. Results One forty‐six (27.9%) showed some form injury, with 111...
The COVID-19 pandemic has highlighted the role of breastfeeding in providing passive immunity to infants via specific anti-SARS-CoV-2 antibodies breast milk. We aimed quantify these across different lactation stages and identify influencing factors. This prospective study involved mother-child dyads from Innsbruck University Hospital, Austria, with a positive maternal SARS-CoV-2 test during pregnancy or peripartum between 2020 2023. collected milk samples at various analyzed anti-Spike S1...
Neonatal brain injury remains a significant issue with limited treatment options. This study investigates the potential of endogenous neurosteroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) as neuroprotective agents, building on evidence their mechanisms in adult models. The primary objective was to evaluate anti-oxidative properties mouse model neonatal hypoxic–ischemic injury. Using modified Rice–Vannucci model, induced 7-day-old pups, followed by various concentrations...
Preterm birth is frequently associated with altered thyroid hormone levels in the newborn period. Recent data suggest a role of prematurity independent size also childhood dysfunction. Whether high-risk population former very preterm infants (VPI) particularly susceptible to alterations currently unknown. The aim present study was assess whether VPI display changes status comparison term-born controls at preschool age. Free triiodothyronine (fT3), free thyroxine (fT4), and stimulating (TSH)...
Background Little is known about plasma apolipoprotein profiles in very preterm‐born and term‐born preschool children compared with the adult population. This of particular interest because composition might contribute to cardiometabolic outcome later life. Methods Results Children aged 5 7 years born at term or <32 weeks gestation were included. Apolipoprotein concentrations measured collected after an overnight fast using multiple‐reaction monitoring‐based mass spectrometry. Twelve...
To assess whether amplitude-integrated electroencephalography (aEEG) alterations in the newborn period are associated with poor precursor skills of literacy at five years age children born preterm.Between October 2007 and September 2011 248 preterm infants were eligible for study Innsbruck Medical University Hospital. aEEG was analysed dominating background activity, calculation percentage continuous Burdjalov scoring system, minimum, mean maximum amplitude. At years, we evaluated by...
<b><i>Introduction:</i></b> Neurological consequences of preterm infants born to mothers with gestational diabetes mellitus (GDM) are unclear. In this pilot study, we investigated the effect GDM on brain activity in very infants. <b><i>Methods:</i></b> Preterm &lt;32 weeks compared age- and sex-matched controls between 2011 2018 were included. Amplitude-integrated electroencephalography (aEEG) was assessed for total maturation individual...