A5069675212- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Tendon Structure and Treatment
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Spinal Cord Injury Research
- Tissue Engineering and Regenerative Medicine
- Viral Infections and Immunology Research
- Spaceflight effects on biology
- Cardiac Structural Anomalies and Repair
- Otolaryngology and Infectious Diseases
- Streptococcal Infections and Treatments
- Cardiac and Coronary Surgery Techniques
- Congenital heart defects research
- Heat shock proteins research
- Medical and Biological Ozone Research
- Bee Products Chemical Analysis
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2024
Houston Methodist
2022-2024
University Hospital of Bern
2022
University of Bern
2022
University Hospital Innsbruck
2015-2016
Hôpital Necker-Enfants Malades
2014
Université Paris Cité
2014
Hospices Civils de Lyon
2008
Hôpital Edouard Herriot
2004-2008
As many current approaches for heart regeneration exert unfavourable side effects, the induction of endogenous repair mechanisms in ischaemic disease is particular interest. Recently, exosomes carrying angiogenic miRNAs have been described to improve function. However, it remains challenging stimulate specific release reparative myocardium. In present study, we sought test hypothesis that physical stimulus shock wave therapy (SWT) causes exosomes. We aimed substantiate pro-angiogenic impact...
Abstract Background and Aims In chronic ischaemic heart failure, revascularisation strategies control symptoms but are less effective in improving left ventricular ejection fraction (LVEF). The aim of this trial is to investigate the safety cardiac shockwave therapy (SWT) as a novel treatment option its efficacy increasing function by inducing angiogenesis regeneration hibernating myocardium. Methods single-blind, parallel-group, sham-controlled (cardiac for ischemic CAST-HF; NCT03859466)...
Abstract Aims Imbalances of iron metabolism have been linked to the development atherosclerosis. However, subjects with hereditary haemochromatosis a lower prevalence cardiovascular disease. The aim our study was understand underlying mechanisms by combining data from genome-wide association analyses in humans, CRISPR/Cas9 genome editing, and loss-of-function studies mice. Methods results Our analysis Global Lipids Genetics Consortium (GLGC) dataset revealed that single nucleotide...
Abstract Aims/hypothesis Sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used in the treatment of type diabetes, heart failure and chronic kidney disease. Their role prevention diet-induced metabolic deteriorations, such as obesity, insulin resistance fatty liver disease, has not been defined yet. In this study we set out to test whether empagliflozin prevents weight gain dysfunction a mouse model obesity resistance. Methods C57Bl/6 mice were fed western-type diet supplemented...
Calcific aortic valve disease (CAVD) is characterized by a phenotypic switch of valvular interstitial cells to bone-forming cells. Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition at the interface between innate immunity and tissue repair. Type I interferons (IFNs) not only crucial for an adequate antiviral response but also implicated in bone formation. We hypothesized that accumulation endogenous TLR3 ligands leaflets may promote generation osteoblast-like...
Abstract OBJECTIVES Barlow’s disease is a specific sub-form of mitral valve (MV) disease, characterized by diffuse excessive tissue and multi segment prolapse. The anterolateral mini-thoracotomy represents the standard access for MV regurgitation in many centres. It still remains unclear which surgical technique provides best results. Therefore, aim this study was to compare operative safety mid-term outcomes after (i) isolated annuloplasty, (ii) use additional artificial chordae or (iii)...
Abstract Aims Cardiac shockwave therapy (SWT) improves left ventricular (LV) function in patients with ischaemic cardiomyopathy. Shockwave activates Toll-like receptor 3 (TLR3), a receptor-inducing chromatin remodelling and nuclear reprogramming of cardiac cells. We hypothesized that mechanical activation TLR3 facilitates fibroblasts towards endothelial cells restoring myocardial perfusion function. Methods results Human were treated by stimulation via SWT or agonist Poly(I:C) the presence...
Abstract Visual snow syndrome is characterized by a continuous visual disturbance resembling badly tuned analogue television and additional non-visual symptoms causing significant disability. The natural course of has not hitherto been studied. In this prospective longitudinal study, 78 patients with the diagnosis made in 2011 were re-contacted 2019 to assess symptom evolution using semi-structured questionnaire. Forty (51% 78) interviewed after 84 ± 5 months (mean SD). all patients, had...
Background Mechanical stimulation of acute ischemic myocardium by shock wave therapy ( SWT ) is known to improve cardiac function induction angiogenesis. However, in chronic heart failure poorly understood. We aimed study whether mechanical upon improves angiogenesis and postnatal vasculogenesis dissect underlying mechanisms. Methods Results was applied a mouse model myocardial ischemia. To effects on vasculogenesis, wild-type mice received bone marrow transplantation from green fluorescence...
Background Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular repair. Shock wave treatment was shown to induce angiogenesis regeneration in ischemic tissue by modulation early inflammatory response via Toll‐like receptor ( TLR) 3 signaling. In preclinical clinical studies, shock had favorable effect on myocardium. We hypothesized that also may have beneficial ischemia. Methods Results A model mice slice cultures ex vivo...
Spinal cord injury (SCI) remains a devastating condition with poor prognosis and very limited treatment options. Affected patients are severely restricted in their daily activities. Shock wave therapy (SWT) has shown potent regenerative properties bone fractures, wounds, ischemic myocardium via activation of the innate immune receptor TLR3. Here, we report on efficacy SWT for regeneration SCI. improved motor function decreased lesion size WT but not Tlr3–/– mice inhibition neuronal...
Abstract Shock wave treatment ( SWT ) was shown to induce regeneration of ischaemic myocardium via Toll‐like receptor 3 TLR 3). The antimicrobial peptide LL 37 gets released by mechanical stress and is known form complexes with nucleic acids thus activating receptors. We suggested that in the acute setting prevents from development heart failure RNA /protein release. Myocardial infarction mice induced followed subsequent . Heart function assessed 4 weeks later transthoracic echocardiography...
Shock wave therapy (SWT) has been shown to induce angiogenesis in ischaemic muscle. However, the mechanism of action remains unknown. Macrophages are crucial for angiogenic responses after injury. The M2 macrophage subset enables tissue repair and induces angiogenesis. It was hypothesized that effects SWT at least partly caused by enhanced recruitment. C57BL/6 mice were subjected hind limb ischaemia with subsequent or sham treatment. Muscles analysed via immunofluorescence staining,...
Abstract OBJECTIVES Ischaemia and subsequent reperfusion during heart transplantation inevitably result in donor organ injury. Toll-like receptor (TLR)-3 is a pattern recognition activated by viral endogenous RNA released injured cells. We hypothesized that ischaemia/reperfusion injury (IRI) leads to release with TLR3 activation transplanted hearts. METHODS Human endothelial cells were subjected IRI treated agonist polyinosinic–polycytidylic acid or TLR3/double-stranded complex inhibitor....
Background and objective Continuous monitoring of cardiac output during liver transplantation is essential to evaluate the patient's haemodynamic tolerance acute volume variations. The aim this study was compare values obtained with a transoesophageal echo-Doppler those continuous thermodilution pulmonary artery catheter. Methods Twenty adult patients were prospectively studied 5 min hepatic vascular exclusion test performed at end dissection phase. Echo-Doppler output, mean arterial...
Abstract OBJECTIVES Mechanical strain plays a major role in the development of aortic calcification. We hypothesized that (i) valvular calcifications are most pronounced at localizations subjected to highest mechanical and (ii) calcification patterns different patients with bicuspid tricuspid valves. METHODS Multislice computed tomography scans 101 severe stenosis were analysed using 3-dimensional post-processing software quantify valves (n = 51) 50) after matching. RESULTS Bicuspid...
Coronary artery diseases (CAD) remains a severe socio-economic burden in the Western world. obstruction and subsequent myocardial ischemia result progressive replacement of contractile myocardium with dysfunctional, fibrotic scar tissue. Post-infarctional remodeling is causal for concomitant decline left-ventricular function fatal syndrome heart failure. Available neurohumoral treatment strategies aim at improvement symptoms. Despite extensive research, therapeutic options regeneration,...
Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria syndrome well-known premature aging disease. Minor levels progerin readily expressed in blood healthy individuals due alternative splicing. Previously, we found an association increased mRNA with overweight and chronic inflammation (hs-CRP). Here, aimed elucidate...