A5082989365- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Cardiac pacing and defibrillation studies
- Cardiac Fibrosis and Remodeling
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Cardiovascular Health and Risk Factors
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
University Hospital Innsbruck
2019-2021
University Clinic of Traumatology
2019
Background: The high accuracy of feature-tracking cardiac magnetic resonance (CMR) imaging qualifies this novel modality as potential gold standard for myocardial strain analyses in ST-elevation infarction patients; however, the incremental prognostic validity feature-tracking-CMR over left ventricular ejection fraction (LVEF) and damage remains unclear. This study therefore aimed to determine value measured by prediction clinical outcome following infarction. Methods: prospective...
In patients with acute ST-elevation myocardial infarction (STEMI), elevated concentrations of inflammatory markers are correlated worse clinical outcome. The aim this study was comprehensively to investigate the relationship circulating inflammation and microvascular damage after STEMI. 111 consecutive STEMI patients, blood samples were obtained on admission from day 1 4 primary percutaneous coronary intervention analysed for high-sensitivity C-reactive protein (hs-CRP), white cell count...
Cardiac magnetic resonance (CMR) is the gold-standard modality for assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, commonly used criteria have never been validated hard clinical events. We therefore aimed to define clear CMR LV following STEMI with proven prognostic impact. This observational study included 224 patients suffering from acute STEMI. was performed within 1 week and 4 months after evaluate different including...
Coronavirus disease 19 (COVID-19) and its associated restrictions could affect ischemic times in patients with ST-segment elevation myocardial infarction (STEMI). The objective of this study was to investigate the influence COVID-19 outbreak on consecutive all-comer STEMI patients. We included (n = 163, median age: 61 years, 27% women) who were referred seven tertiary care hospitals across Austria for primary percutaneous coronary intervention between 24 February 2020 (calendar week 9) 5...
The severity of myocardial tissue damage following ST-elevation infarction (STEMI) strongly determines short- and long-term prognosis. This study explored the impact coronavirus disease 2019 (COVID-19) pandemic associated public health restrictions on infarct severity.STEMI patients treated with primary percutaneous coronary intervention (PCI) included in prospective Magnetic Resonance Imaging Acute ST-Elevation Myocardial Infarction (MARINA-STEMI) cohort from 2015- 2020 (n = 474) were...
Beyond therapeutic implications, PCSK9 (proprotein convertase subtilisin/kexin 9) has emerged as a promising cardiovascular biomarker. The exact role of in the setting acute ST-elevation myocardial infarction (STEMI) is incompletely understood. We aimed to investigate association with ischemia-reperfusion injury, visualized by cardiac magnetic resonance imaging, patients STEMI revascularized primary percutaneous coronary intervention (PCI).
Transcatheter aortic valve replacement (TAVR) is the preferred treatment for older patients with severe stenosis outcomes influenced by age and sex. Computed tomography (CT) reference imaging modality TAVR planning, while cardiac magnetic resonance (CMR) an emerging alternative this indication. The aim of study was to evaluate impact sex on implantation success in undergoing CT- or CMR-guided TAVR. This a secondary analysis randomized TAVR-CMR trial comparing planning CT CMR (NCT03831087)....
The role of C-reactive protein velocity (CRPv) as an early and sensitive marker excessive inflammatory response in the setting acute ST-elevation myocardial infarction (STEMI) is only poorly understood. aim this study was to investigate, patients with STEMI treated primary percutaneous coronary intervention (PCI), association CRPv microvascular infarct pathology.This prospective cohort included a total 316 undergoing PCI. defined difference between CRP 24 ± 8 h at hospital admission, divided...
Abstract Aim We aimed to investigate the comparative prognostic value of left ventricular ejection fraction (LVEF), mitral annular plane systolic excursion (MAPSE), fast manual long-axis strain (LAS) and global longitudinal (GLS) determined by cardiac magnetic resonance (CMR) in patients after ST-segment elevation myocardial infarction (STEMI). Methods results This observational cohort study included 445 acute STEMI treated with primary percutaneous coronary intervention (pPCI)....
Computed tomography (CT) is recommended for guiding transcatheter aortic valve replacement (TAVR). However, a sizable proportion of TAVR candidates have chronic kidney disease, in whom the use iodinated contrast media limitation. Cardiac magnetic resonance imaging (CMR) promising alternative, but randomized data comparing effectiveness CMR-guided versus CT-guided are lacking.An investigator-initiated, prospective, randomized, open-label, noninferiority trial was conducted at 2 Austrian heart...
Little is known about the clinical relevance of interleukin (IL)-6 in patients with acute ST-elevation myocardial infarction (STEMI). This study examined possible associations plasma IL-6 concentrations infarct size (IS), reperfusion injury and adverse left ventricular remodelling (LVR), STEMI treated primary percutaneous coronary intervention (PCI).We prospectively included 170 consecutive (median age 57 years, 14% women) PCI between 2017 2019. Blood samples for biomarker analyses including...
Background Severity of myocardial tissue injury is a main determinant morbidity and death related to ST-segment-elevation infarction (STEMI). Temporal trends infarct characteristics at the level have not been described. This study sought assess temporal in through comprehensive assessment by cardiac magnetic resonance imaging standardized time point early after STEMI. Methods Results We analyzed patients with STEMI treated percutaneous coronary intervention University Hospital Innsbruck who...
The purpose of this study was to assess the comparative prognostic value mitral annular plane systolic excursion (MAPSE) versus left ventricular ejection fraction (LVEF), measured by cardiac magnetic resonance (CMR) imaging in patients with ST-elevation myocardial infarction (STEMI) treated primary percutaneous coronary intervention (pPCI). CMR performed 255 STEMI within 2 days (interquartile range (IQR) 2–4 days) after infarction. included MAPSE measurement on CINE 4-chamber view. Patients...
BackgroundHigh-sensitivity cardiac troponin T (hs-cTnT) represents the biomarker of choice for infarct size (IS) estimation in patients with acute ST-elevation myocardial infarction (STEMI). However, admission values hs-cTnT are only weakly associated IS. The aim this study was to investigate incremental value different biomarkers measured on IS STEMI patients.MethodsIn prospective observational study, we included 161 consecutive treated primary percutaneous coronary intervention (pPCI)....
BackgroundAcute myocardial infarction is associated with the release of co-transmitter neuropeptide-Y (NPY). NPY acts as a potent vasoconstrictor and microvascular dysfunction after ST-elevation (STEMI). This study comprehensively evaluated association plasma function infarct severity, visualized by cardiac magnetic resonance (CMR) imaging, in STEMI patients revascularized primary percutaneous coronary intervention (PCI).MethodsIn this observational study, we included 260 enrolled...
Abstract Objectives To prospectively compare unenhanced quiescent-interval single-shot MR angiography (QISS-MRA) with contrast-enhanced computed tomography (CTA) for contrast-free guidance in transcatheter aortic valve intervention (TAVI). Methods Twenty-six patients (mean age 83 ± 5 years, 15 female [58%]) referred TAVI evaluation underwent QISS-MRA aortoiliofemoral access and non-contrast three-dimensional (3D) “whole heart” MRI prosthesis sizing on a 1.5-T system. Contrast-enhanced CTA...
<h3>Importance</h3> Myocardial tissue injury due to acute ST-elevation myocardial infarction (STEMI) initiates an inflammatory response that leads a release of systemic biomarkers, including C-reactive protein (CRP) and white blood cells, consequently reducing the usefulness these routine biomarkers for identifying concomitant infections. The clinical role procalcitonin (PCT), promising marker bacterial infection, detect infection in STEMI is unknown, mainly because it unclear whether per se...