A5065179101- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Functional Brain Connectivity Studies
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Blood Pressure and Hypertension Studies
- Moyamoya disease diagnosis and treatment
- Renal and Vascular Pathologies
- Optical Imaging and Spectroscopy Techniques
- Peripheral Artery Disease Management
- Pharmaceutical Practices and Patient Outcomes
- MRI in cancer diagnosis
- Oropharyngeal Anatomy and Pathologies
- Cerebrovascular and genetic disorders
- Chronic Kidney Disease and Diabetes
Universität Hamburg
2019-2025
University Medical Center Hamburg-Eppendorf
2019-2025
Klinik und Poliklinik für Neurologie
2019-2023
There is evidence suggesting a detrimental effect of asymptomatic carotid artery stenosis on cognitive function even in the absence ischemic cerebral lesions. Hypoperfusion has been suggested as pathophysiological mechanism causing impairment. We aimed to assess performance and perfusion changes patients with without lesions by arterial spin labeling (ASL) contrast enhanced (CE) MRI before after revascularization therapy. 17 unilateral high-grade (≥70%) structural brain underwent ASL CE...
In ischemic stroke, there is limited data regarding the impact of baseline hyperglycemia on treatment effect recanalization neurological recovery. This study aimed to directly compare-how short- and long-term serum glucose levels modify functional outcome in patients with stroke specifically analyze occurrence delayed recovery ("stunned brain phenomenon"). Observational retrospective analysis including anterior circulation large vessel occlusion undergoing mechanical thrombectomy following...
Abstract Cerebral small vessel disease is a common in the older population and recognized as major risk factor for cognitive decline stroke. Small considered global brain impacting integrity of neuronal networks resulting disturbances structural functional connectivity. A core feature cerebral commonly present on neuroimaging white matter hyperintensities. We studied high-resolution resting-state EEG, leveraging source reconstruction methods, 35 participants with varying degree...
Kidney dysfunction (KD) is a risk factor for cerebrovascular events and has been shown to have detrimental effect on outcome after stroke. We evaluated the influence of KD at admission pre-existing diagnosis chronic kidney disease (CKD) before thrombectomy anterior circulation stroke functional independence mortality 90 days in this cross-sectional study.
We investigated changes of cortical thickness and its association with cognitive performance in patients high-grade carotid artery stenosis without ischemic brain lesions. studied 25 unilateral ≥50% age-matched controls. All subjects underwent T1-weighted MRI, was measured 33 regions interest each hemisphere, as well belonging to the vascular territory middle cerebral (MCA). General linear mixed models were fitted dependent variable thickness. Cognitive assessment comprised Stroop Test Trail...
Internal carotid artery stenosis is a risk factor for ischemic stroke. Even in the absence of visible structural brain changes, patients with asymptomatic are prone to cognitive impairment. On neuronal level, it was suggested that may lead disturbed functional connectivity. If so, revascularization should have an effect on hypothesized network disturbances. We studied connectivity motor by resting-state electroencephalography 12 high grade before and after interventional or surgical as...
Abstract Purpose Comorbidities and polypharmacy are risk factors for worse outcome in stroke. However, comorbidities mostly studied separately with various approaches to assess them. We aimed analyze the impact of comorbidity burden on functional acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT). Methods Acute large vessel occlusion (LVO) treated MT from a prospective observational study were analyzed. Relevant was defined as Charlson Comorbidity Index (CCI) score...
Abstract Introduction Revascularization procedures in carotid artery stenosis have shown a positive effect the restoration of cerebral oxygen metabolism as assessed by T2’ (T2 prime) imaging well capillary homeostasis measurement transit time heterogeneity (CTH); however, data patients with asymptomatic without manifest brain lesions are scarce. Patients and Methods The revascularization on hemodynamic profile was evaluated 13 high-grade ischemic using dynamic susceptibility contrast...
Background Blood-brain barrier (BBB) leakage measured with dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) has been associated hemorrhagic transformation in acute ischemic stroke (AIS). However, the influence of pre-thrombolysis BBB on infarct growth not studied. Therefore, we aimed to characterize integrity according tissue state at admission and fate follow-up MRI. Methods This is a post-hoc analysis Efficacy Safety MRI-Based Thrombolysis Wake-Up Stroke (WAKE-UP) trial...
Chronic cerebral hypoperfusion caused by asymptomatic high-grade stenosis of the internal carotid artery (ICA) has been associated with impaired cognitive function. Only few studies exist on underlying changes functional connectivity (FC). 20 patients unilateral ICA without MRI lesions and 25 aged-match controls underwent resting-state (rsfMRI) neuropsychological assessment. Patients were examined within ten days before 6–10 weeks after surgical or interventional revascularization stenosis....
Introduction This study assesses the association of comorbidity burden and polypharmacy with self-reported quality life after stroke. Patients methods We performed a post-hoc analysis prospective, single-center, observational outcome evaluation by patient-reported measures in stroke clinical practice. Consecutive patients acute ischemic (AIS) were enrolled health–related (HrQoL) was assessed 90 days using Patient-reported Outcomes Measurement Information System 10-Question Short-Form...
The aims of this study were to evaluate the relationship clinical and imaging baseline factors treatment on occurrence early neurological improvement (ENI) in WAKE-UP trial MRI-guided intravenous thrombolysis unknown onset stroke examine association ENI with long-term favorable outcome patients treated thrombolysis.We analyzed data from all at least moderate severity, reflected by an initial National Institutes Health Stroke Scale (NIHSS) score ≥4 randomized trial. was defined as a decrease...