A5068530545- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Neurological disorders and treatments
- Ion channel regulation and function
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Cardiovascular Syncope and Autonomic Disorders
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Reproductive Health and Technologies
- Tuberculosis Research and Epidemiology
- LGBTQ Health, Identity, and Policy
- Pharmaceutical studies and practices
- Sexuality, Behavior, and Technology
- HIV, Drug Use, Sexual Risk
- Antiplatelet Therapy and Cardiovascular Diseases
- Sarcoidosis and Beryllium Toxicity Research
University Hospital Münster
2016-2025
Boston University
2024
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2009-2022
Fenway Health
2019-2022
University of Münster
2005-2021
Harvard University
2019
Wentworth Institute of Technology
2018
Klinik für Schlafmedizin
2013-2017
Universität Hamburg
2012
University Medical Center Hamburg-Eppendorf
2012
Objective To examine associations between recalled access to gender-affirming hormones (GAH) during adolescence and mental health outcomes among transgender adults in the U.S. Methods We conducted a secondary analysis of 2015 Transgender Survey, cross-sectional non-probability sample 27,715 Using multivariable logistic regression adjusting for potential confounders, we examined GAH early (age 14–15), late 16–17), or adulthood ≥18) adult outcomes, with participants who desired but never...
Abstract Aims In-hospital complications of catheter ablation for atrial fibrillation (AF), flutter (AFL), and ventricular tachycardia (VT) may be overestimated by analyses administrative data. Methods results We determined the incidences in-hospital mortality, major bleeding, stroke around AF, AFL, VT ablations in four German tertiary centres between 2005 2020. All cases were coded G-DRG- OPS-systems. Uniform code search terms applied defining both types occurrence adverse events including...
Radiofrequency catheter ablation is increasingly used in the treatment of atrial fibrillation. Esophageal wall changes varying from erythema to ulcers have been described by endoscopy up 47% patients following pulmonary vein isolation (PVI). Although esophageal are frequently reported, development a left (LA)-esophageal fistula fortunately rare. Nevertheless, mucosal may just represent "the tip iceberg." The aim this study was, therefore, investigate more subtle and injuries posterior LA,...
Background— Recently, subcutaneous implantable cardioverter-defibrillator (S-ICD) has become available. The aim of our study was to assess the efficacy S-ICD in a clinical setting. Methods and Results— Between June 2010 July 2011, 40 consecutive patients (42±15 years; body mass index, 27±6 kg/m 2 ; left ventricular ejection fraction, 47±15%; 28 men) received an for primary (n=17) or secondary prevention (n=23 [58%]) at 3 institutions Germany. Intraoperative defibrillation testing failed 1...
Background: Previous studies suggest a direct effect of sacubitril on cardiac electrophysiology and indicate potential arrhythmic interactions between antiarrhythmic drugs. Therefore, the aim this study was to explore electrophysiologic effects combining with drugs d,l-sotalol mexiletine in isolated hearts. Methods results: A total 25 rabbit hearts were perfused using Langendorff setup. Following baseline data collection, treated (25 µM, 13 hearts) or (100 12 hearts). Monophasic action...
Background: The long‐QT syndromes (LQTS) are inherited electrical cardiomyopathies characterized by prolonged ventricular repolarization and arrhythmias. Several genetic reports have associated defects in LQTS‐causing genes with atrial fibrillation (AF). We therefore studied whether arrhythmias occur patients LQTS under daily‐life conditions. Methods: systematically assessed matched controls using implanted defibrillators or pacemakers as monitors of rhythm a nested case‐control study....
Abstract Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number patients with arrhythmias who require antiarrhythmic drug therapy and may, e.g., otherwise and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability blocking fast sodium channels cardiomyocytes, it has played minor to moderate role throughout recent decades. Nevertheless, certain structural heart disease suffering...
ABSTRACT Background The subcutaneous implantable defibrillator (S‐ICD) is an alternative to transvenous defibrillators. present analysis presents real‐world data from patients with S‐ICD and a follow‐up duration of 10 years or more. Methods Results Between July 2010 November 2013 76 systems were implanted. After years, 67 (88.1%) was available. Mean 10.7 ± 1.3 years. Forty‐seven (70.2%) still alive active therapy. Eight (11.9%) died during follow‐up. In eight (11.9%), conversion ICD system...
Abstract Background In about 8% of survivors sudden cardiac death, no structural or electrical heart disease can be identified. Some these patients with idiopathic ventricular fibrillation (IVF) present ECG markers early repolarization (Early Repolarization Syndrome, ERS). The T peak – end interval has been linked to increased arrhythmic risk in different clinical settings, such as Brugada syndrome hypertrophic cardiomyopathy. As there is limited data the relationship and arrhythmogenesis...
<h3>Objective:</h3> To investigate predisposing factors for cardiac resynchronisation therapy (CRT) response. <h3>Design:</h3> Single-centre study. <h3>Setting:</h3> University hospital in Germany. <h3>Patients:</h3> 122 consecutive patients with heart failure (mean (SD) age 65 (11) years; ischaemic/non-ischaemic 41%/55%; New York Heart Association (NYHA) class 3.1 (0.3); left ventricular ejection fraction 24.4 (8.1)%; QRS width 170 (32) ms, quality of life (QoL) 43.5 (19.2)) an indication...
AimsThe use of implantable cardioverter defibrillators (ICD) in patients with torsade de pointes (TdP) and ventricular fibrillation the presence acquired long QT syndrome (aLQTS) is under debate, partly due to fact that aLQTS potentially reversible currently no long-term follow-up data are available. We aimed evaluate who had received an defibrillator for secondary prevention sudden cardiac arrest (SCA).
Pulmonary veins (PV) play a pivotal role in atrial fibrillation (AF). Anatomical variants of PV have been described and related to higher arrhythmogenic potential. The aim this study was compare the prevalence diameters ostia AF patients controls.Variants were defined as right or left common (RCO, LCO), middle top . A long trunk (LCT) an LCO with distance first branching ≥ 10 mm. Multislice contrast-enhanced thoracic computed tomography performed prior ablation 166 consecutive patients,...