A5103072579- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Neonatal Health and Biochemistry
- Transplantation: Methods and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Microtubule and mitosis dynamics
- Liver Diseases and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
- Fungal and yeast genetics research
- Genetic Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic function and diabetes
- Viral-associated cancers and disorders
- Organ Donation and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Cellular transport and secretion
- Alcohol Consumption and Health Effects
Baylor College of Medicine
2016-2025
Texas Children's Hospital
2004-2025
Michael E. DeBakey VA Medical Center
2011-2025
Wellesley College
2014-2022
Yale University
2008-2014
Hospital of the University of Pennsylvania
2014
Charité - Universitätsmedizin Berlin
2006
Houston Methodist
2006
Deutsches Herzzentrum der Charité
2006
Methodist Hospital
2006
Patients undergoing liver transplantation for hepatitis B-related disease are prone to recurrence. The mainstay of prophylaxis has been passive immunotherapy with B immune globulin (HBIG). Antiviral therapy lamivudine proven effective in lowering virus (HBV) DNA and improving histology patients infection; its role against recurrence following is under investigation. Viral breakthrough resistance, however, a significant problem monotherapy either HBIG or lamivudine. efficacy combination...
Ca2+ influx through plasma membrane lesions triggers a rapid repair process that was previously shown to require the exocytosis of lysosomal organelles (Reddy, A., E. Caler, and N. Andrews. 2001. Cell. 106:157-169). However, how leads resealing has remained obscure, particularly for stable caused by pore-forming proteins. In this study, we show Ca2+-dependent after permeabilization with bacterial toxin streptolysin O (SLO) requires endocytosis via novel pathway removes SLO-containing pores...
Background and Aims The surge in unhealthy alcohol use during the COVID‐19 pandemic may have detrimental effects on rising burden of alcohol‐associated liver disease (ALD) transplantation (LT) USA. We evaluated effect temporal trends for LT including ALD. Approach Results Using data from United Network Organ Sharing, we analyzed wait‐list outcomes USA through March 1, 2021. In a short‐period analysis, patients listed or transplanted between June 2019, February 29, 2020, were defined as...
With continuing improvements in medical devices and more than a decade since the 2006 United Network for Organ Sharing (UNOS) allocation policy, it is pertinent to assess survival among patients on heart transplantation waiting list, especially given recently approved 2018 UNOS policy.To outcomes transplant list during past 3 decades examine association of ventricular assist (VADs) policy with survival.A retrospective cross-sectional used database perform an analysis 95 323 candidates...
Membrane trafficking during cytokinesis is not well understood. We used advanced live cell imaging techniques to track exocytosis of single vesicles determine whether constitutively exocytosed membrane focally delivered the cleavage furrow. Ultrasensitive three-dimensional confocal time-lapse temperature-sensitive cargo protein vesicular stomatitis virus protein–yellow fluorescent revealed that from both daughter cells traffic out Golgi and into furrow, following curvilinear paths....
Older recipient age is associated with worse posttransplant survival. Although the median of liver disease patients undergoing orthotopic transplantation (OLT) continues to rise, prognostic factors for survival specific older have not been defined. To address this issue, United Network Organ Sharing/Organ Procurement and Transplantation outcome database was searched identify 8070 recipients 60 years old or who underwent from 1994 2005. Prognostic were assessed univariate analysis...
Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate survival the absence orthotopic transplantation (OLT) is reportedly 38% at 3 years and 28% 5 years. Moderate severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm Hg] associated a perioperative mortality 50%. Single-center series have demonstrated feasibility short-term efficacy OLT after controlled vasodilators, but long-term outcomes not been reported. Our aim was determine...
Investigating outcomes after marginal allograft transplant is essential in determining appropriate and more aggressive use of these allografts.
The authors' goal was to determine the effects of specific binding and blockade P- E-selectins by a soluble P-selectin glycoprotein ligand-1 (PSGL-1) in rat models hepatic vivo warm ischemia ex cold ischemia. authors also sought effect selectin on isograft survival syngeneic orthotopic liver transplant model.Ischemia/reperfusion (I/R) injury is major factor poor graft function after transplantation, which may profoundly influence early late changes. It hypothesized that I/R leads...
The relative inefficiency of the islet purification process may hamper obtaining enough islets for transplantation even with adequate pre-purification counts. In this study, we determined effect an additional step on total yields and pancreas utilization at our center.Twenty-five pancreata were processed using automated method followed by continuous gradient (CGP), less pure fractions sub-jected to rescue (RGP). CGP RGP combined transplanted into patients type 1 diabetes.CGP showed no...
Partial hepatectomy leads to an orchestrated regenerative response, activating a cascade of cell signaling events necessary for cycle progression and proliferation hepatocytes. However, the identity humoral factors that trigger activation these pathways in concerted response hepatocytes remains elusive. In recent years, extracellular ATP has emerged as rapidly acting molecule influences variety liver functions, but its role hepatocyte growth regeneration is unknown. this study, we sought...
Background. Poor linear growth after pediatric orthotopic liver transplantation (OLT) is a well-described phenomenon. We have undertaken bivariate and multivariate analysis of multiple factors that might effect postOLT in all children who underwent at single center, with survival > 1 year adequate follow-up. Methods. Standardized height score (Z score) deficit (centimeters below the 50th percentile) were computed for each patient over time. The variables assessed (i) age OLT, (ii) gender,...
To formulate a model predicting survival after liver retransplantation, we analyzed in detail the last 150 cases of hepatic retransplantation at UCLA. Cox proportional hazards regression analysis identified five variables that demonstrated independent simultaneous prognostic value estimating patient retransplantation: (1) age group (pediatric or adult), (2) recipient requiring preoperative mechanical ventilation, (3) donor organ cold ischemia ≥12 hr, (4) serum creatinine, and (5) total...
The pediatric end-stage liver disease (PELD) model accurately estimates 90-day waitlist mortality for transplant candidates, but it has been unclear if PELD can identify patients who will derive survival benefit from undergoing transplantation (LT), correlates with posttransplant survival, or whom LT would be futile. Pediatric underwent between 2001 and 2004 were enrolled through the United Network Organ Sharing Procurement Transplant database. Survival was measured in terms of life-years...