A5003815844- COVID-19 Impact on Reproduction
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Organ Donation and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Transplantation: Methods and Outcomes
- Studies on Chitinases and Chitosanases
- Immune Cell Function and Interaction
- Phytochemical compounds biological activities
- Abdominal vascular conditions and treatments
- Clinical Nutrition and Gastroenterology
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Cellular Mechanics and Interactions
- Parvovirus B19 Infection Studies
- Marine Biology and Environmental Chemistry
- Congenital Anomalies and Fetal Surgery
- Insect Pest Control Strategies
- Histiocytic Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Ginger and Zingiberaceae research
- Long-Term Effects of COVID-19
The University of Texas Health Science Center at Houston
2019-2025
The University of Texas MD Anderson Cancer Center
2025
Texas A&M University
2020
Wake Forest University
2020
Forest Institute
2020
Charlottesville Medical Research
2020
John Wiley & Sons (United States)
2020
Instituto de Investigaciones Biomédicas Sols-Morreale
2003
Universidad Autónoma de Madrid
2003
École Normale Supérieure de Lyon
1989-1990
The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult have been published, literature centered on the population is limited. We herein report a multi-center, multi-organ cohort analysis COVID-19-positive ≤ 18 years at time transplant. Data were collected via institutions' respective electronic medical record systems. Local review boards approved this cross-institutional study. Among 5 centers, 26 patients...
Objective Previous studies indicate that eosinophils are recruited into the allograft following orthotopic liver transplantation and protect from ischaemia reperfusion (IR) injury. In current studies, we aim to explore whether their protective function could outlast during repair. Design Eosinophil-deficient mice adoptive transfer of bone marrow-derived (bmEos) were employed investigate effects on tissue repair regeneration after hepatic IR Aside exogenous cytokine or neutralising antibody...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus responsible for worldwide pandemic has forced drastic changes in medical practice an alarmingly short period of time. Caregivers must modify their strategies as well optimize the utilization resources to ensure public and patient safety. For organ transplantation, particular, loss lifesaving organs transplantation could lead increased waitlist mortality. The priority is select uninfected donors transplant...
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper immune responses. Unexpectedly, we identified rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no were detectable healthy tissues before Studies with two genetic mouse models eosinophil deficiency and model antibody-mediated depletion revealed exacerbated injury ischemia reperfusion. Adoptive transfer bone marrow-derived normalized eosinophil-deficient mice reduced...
Hepatic platelet accumulation contributes to acetaminophen (APAP)-induced liver injury (AILI). However, little is known about the molecular pathways involved in recruitment and whether targeting such could attenuate AILI. Mice were fasted overnight before intraperitoneally (i.p.) injected with APAP at a dose of 210 mg/kg for male mice 325 female mice. Platelets adherent Kupffer cells determined both patients overdosed APAP. The impact α-chitinase 3-like-1 (α-Chi3l1) on alleviation AILI was...
Abstract Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary further morbidity mortality. Preclinical investigations have demonstrated that treatments downregulate microglia activation polarize them toward reparative/anti-inflammatory phenotype improved outcomes in preclinical models. However, no therapy date has translated into proven benefits human patients. Regulatory T cells...
Abstract Phenotypic selection during animal domestication has resulted in unwanted incorporation of deleterious mutations. In horses, the autosomal recessive condition known as Glycogen Branching Enzyme Deficiency (GBED) is result one these mutations (102C > A), first exon GBE1 gene ( 102C>A ). With recent advances genome editing, this type genetic mutation can be precisely repaired. study, we used RNA-guided nuclease CRISPR-Cas9 (clustered regularly-interspaced short palindromic...
The Epstein-Barr virus DR promoter is located upstream of the PstI repeats, and in addition to TATA box, it contains an region (positions -69 -220) responsive EB1 (Z) (the BZLF1-encoded transcription factor) enhancer with two functionally distinct domains, A B. Domain B has been described as a B-cell-specific EB1-responsive element (P. M. Lieberman, J. Hardwick, S. D. Hayward, Virol. 63:3040-3050, 1989) activated synergistically by R, EBV early product encoded open reading frame BRLF1 (M. A....
OBJECTIVES/GOALS: Incomplete mucosal healingand dysbiosis prevent long-term remission after colitis. IL4 may restore colon homeostasis through its action on immune cells and the microbiome. We will demonstrate this mechanism using genetically modified mice molecular tools. This result in target therapies that prolong patients with IBD. METHODS/STUDY POPULATION: Mice were treated 3% dextran sulfate sodium (DSS) drinking water for 5 days to induce monitored daily changes body weight, monitor...
ABSTRACT The MADS box transcription factor SrfA is required for spore differentiation in Dictyostelium discoideum. srfA null strains form rounded spores that do not resist adverse environmental conditions. Five genes whose expression dependent on have been isolated by differential hybridization. One of these genes, sigC , identical to phg1b previously characterized mutants with altered adhesive properties and found encode a nine-transmembrane-domain protein. This gene transcribed into two...
We describe the successful pediatric liver transplant for unresectable hepatoblastoma in a 4-year-old male with COVID-19 prior to transplant. The first negative NP swab was documented 1 month after initial diagnosis, when SARS-CoV-2 antibodies were also detected. patient actively listed completing four blocks of SIOPEL-4 based regimen due his PRETEXT IV disease which remained unresectable. Following three additional swabs and resolution symptoms 4 weeks, he underwent whole-organ positivity...
Secondary alveolar bone grafts (ABGs) are the standard treatment for defect in patients with cleft lip and palate (CLP), but remain invasive have several disadvantages such as delayed timing of repair, donor-site complications, graft resorption, need multiple surgeries. Earlier management (primary ABG) would be ideal, is limited by minimal bony donor sites available infant. In this study we used a critical-size model rat to investigate use Wharton's Jelly (WJ), stem cell-rich connective...
Abstract Background In pediatric liver transplant recipients, hepatic artery thrombosis and portal vein are major causes of acute graft failure mortality within 30 days transplantation. There is, however, a strong possibility salvage if flow can be re‐established to reduce ischemic injury. The current standard treatment is surgical revascularization, unsuccessful, retransplantation. Due our success in treating these complications with catheter‐directed therapies, we sought summarize publish...
Successful liver transplantation is dependent on restoration of hepatic arterial (HA) flow. Although uncommon, some native recipient HAs are not suitable or inadequate for anastomosis, thereby necessitating extra-anatomic HA reconstruction. Splenic artery transposition (SAT) 1 method reconstruction, in which the splenic transposed to reestablish perfusion donor liver. Due rarity technique, literature describing outcomes limited. In current report, we describe 3 patients (2 adults, pediatric)...
Abstract Background Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report first liver transplants utilizing allografts from SARS‐CoV‐2+ donors. Methods We describe outcomes of two transplant recipients who received organs SARS‐CoV‐2 nucleic acid test‐positive (NAT+) Data were obtained through respective electronic medical record system UNet DonorNet platform. Results The donor was 3‐year‐old boy succumbing to head trauma. One four...
Abstract Hepatic platelet accumulation contributes to acetaminophen (APAP)-induced liver injury (AILI). However, little is known about the molecular pathways involved in recruitment and whether targeting such could attenuate AILI. The present study unveiled a critical role of chitinase 3-like-1 (Chi3l1) hepatic during Increased Chi3l1 platelets were observed patients mice overdosed with APAP. Compared wild-type (WT) mice, -/- developed attenuated AILI markedly reduced accumulation....