A5055936268- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Organ Donation and Transplantation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Liver physiology and pathology
- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Neurological Complications and Syndromes
- Veterinary Pharmacology and Anesthesia
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Abdominal vascular conditions and treatments
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
University Hospital Heidelberg
2023-2025
Heidelberg University
2023-2025
Charité - Universitätsmedizin Berlin
2022-2024
RWTH Aachen University
2015-2023
Humboldt-Universität zu Berlin
2023
Freie Universität Berlin
2023
Universitätsklinikum Aachen
2017-2022
Auguste-Viktoria-Klinik
2022
Semmelweis University
2012-2016
Objective: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold storage (SCS) in extended criteria donation (ECD) liver transplantation (LT) from brain death (DBD). Background: HOPE might improve LT, particularly high-risk settings such as ECD organs DBD, but hypothesis has not yet been tested a randomized controlled trial (RCT). Methods: Between September...
Background: While 4 randomized controlled clinical trials confirmed the early benefits of hypothermic oxygenated machine perfusion (HOPE), high-level evidence regarding long-term outcomes is lacking. The aim this follow-up study from HOPE-ECD-DBD trial was to compare in patients who underwent liver transplantation using extended criteria donor allografts donation after brain death (ECD-DBD), either HOPE or static cold storage (SCS). Methods: Between September 2017 and 2020, recipients...
Muscle wasting and alterations of body composition are linked to clinical outcomes in numerous medical conditions. The role myosteatosis posttransplant remains be determined. Here we investigated skeletal muscle mass as prognostic factors patients undergoing orthotopic liver transplantation (OLT). data 225 consecutive OLT recipients from a prospective database were retrospectively analyzed (May 2010-December 2017). Computed tomography-based skeletal-muscle-index (muscle mass),...
Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage disease. In an attempt to improve availability donor allografts and reduce waiting list mortality, graft acceptance criteria were extended increasingly over decades. The use (ECD) is associated with a higher incidence primary non-function and/or delayed function. As such, several strategies have been developed aiming at reconditioning poor quality ECD allografts. Hypothermic oxygenated machine...
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper immune responses. Unexpectedly, we identified rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no were detectable healthy tissues before Studies with two genetic mouse models eosinophil deficiency and model antibody-mediated depletion revealed exacerbated injury ischemia reperfusion. Adoptive transfer bone marrow-derived normalized eosinophil-deficient mice reduced...
Alterations of body composition, especially decreased muscle mass (sarcopenia) and impaired quality (myosteatosis), are associated with inferior outcomes in various clinical conditions. The data 100 consecutive patients who underwent partial hepatectomy for hepatocellular carcinoma (HCC) at a German university medical centre were retrospectively analysed (May 2008-December 2019). Myosteatosis sarcopenia evaluated using preoperative computed-tomography-based segmentation. We investigated the...
Abstract Background Myosteatosis is associated with perioperative outcomes in orthotopic liver transplantation (OLT). Here, we investigated the effects of body composition and myosteatosis on long‐term graft patient survival following OLT. Methods Clinical data from 225 consecutive OLT recipients a prospective database were retrospectively analysed (May 2010 to December 2017). Computed tomography‐based lumbar skeletal muscle index (SMI) (muscle mass) mean radiation attenuation (SM‐RA)...
Background. Groundbreaking biomedical research has transformed renal transplantation (RT) into a widespread clinical procedure that represents the mainstay of treatment for end-stage kidney failure today. Here, we aimed to provide comprehensive bibliometric perspective on last half-century innovation in RT. Methods. The Web Science Core Collection was used screening yielding 123 303 items during 50-y period (January 1973–October 2022). final data set 200 most-cited articles selected basis...
Basic & translational research (B&TR) in liver transplantation (LT) underwent considerable changes and shifts over the past decade. To capture current landscape future potential of B&TR LT, we conducted an online survey within International Liver Transplantation Society (ILTS) community. The aimed to collect comprehensive data on respondents’ characteristics, qualifications, experiences, activities, providing present state directions LT. Between October 2023 January 2024,...
Score sheets were first introduced 30 years ago to assess pain, distress and suffering in animals. To date, however, there is still no general agreement on their use research practice, only a few publications can be found this topic. In the present work, we demonstrate of special score sheet for severity assessment three postoperative days two showcased studies performed Wistar Lewis rats undergoing liver resection or orthotopic transplantation, respectively. Scoring different criteria total...
Abstract Abdominal infections including cholangitis represent a major problem in patients with perihilar cholangiocarcinoma (pCCA). Thus, we investigated bacterial colonization of the bile ducts and determined its impact on postoperative outcome focusing abdominal infections. A cohort 95 pCCA who underwent surgery between 2010 2019 available intraoperative microbial cultures were analyzed regarding duct infection by group comparisons logistic regressions. 84.2% (80/95) showed 54.7% (52/95)...