A5083227232- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- COVID-19 Clinical Research Studies
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Musculoskeletal pain and rehabilitation
- Health and Medical Studies
- Cardiac Ischemia and Reperfusion
- Pain Management and Placebo Effect
- COVID-19 Impact on Reproduction
- Child Abuse and Trauma
- Child and Adolescent Health
- Infant Health and Development
- Dermatology and Skin Diseases
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Metabolism and Genetic Disorders
- Respiratory and Cough-Related Research
- Complementary and Alternative Medicine Studies
- Lipoproteins and Cardiovascular Health
- Circadian rhythm and melatonin
- Mindfulness and Compassion Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Peripheral Artery Disease Management
- Musicians’ Health and Performance
Humboldt-Universität zu Berlin
1988-2024
Charité - Universitätsmedizin Berlin
2016-2024
Freie Universität Berlin
2018-2024
East Tallinn Central Hospital
2024
Innsbruck Medical University
2023
Zimmer Biomet (Germany)
2019-2022
Klinik und Poliklinik für Kinder- und Jugendmedizin
2017
University of Iowa
2015
University of Salzburg
2012
Objective: The aim of this study was to evaluate peak serum alanine aminotransferase (ALT) and postoperative clinical outcomes after hypothermic oxygenated machine perfusion (HOPE) versus static cold storage (SCS) in extended criteria donation (ECD) liver transplantation (LT) from brain death (DBD). Background: HOPE might improve LT, particularly high-risk settings such as ECD organs DBD, but hypothesis has not yet been tested a randomized controlled trial (RCT). Methods: Between September...
OBJECTIVES: To investigate the effect of extracorporeal cytokine reduction by CytoSorb (CytoSorbents, Monmouth Junction, NJ) on COVID-19–associated vasoplegic shock. DESIGN: Prospective, randomized controlled pilot study. SETTING: Eight ICUs at three sites tertiary-care university hospital Charité—Universitätsmedizin Berlin. PATIENTS: COVID-19 patients with shock requiring norepinephrine greater than 0.2 µg/kg/min, C-reactive protein 100 mg/L, and indication for hemodialysis. INTERVENTIONS:...
Cross-sectional studies suggested that allergy prevalence in childhood is higher boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex-specific of asthma and rhinitis as single multimorbid diseases before puberty onset longitudinal cohort data.In six European population-based birth cohorts MeDALL, we assessed outcomes: current rhinitis, asthma, allergic multimorbidity (ie, concurrent rhinitis), status sensitization by specific serum...
Background: The role of tobacco smoke exposure in the development and persistence asthma rhinoconjunctivitis through childhood into adolescence is unclear. Objectives: We assessed associations parental smoking from fetal life with during adolescence. Methods: analyzed data for 10,860 participants five European birth cohort studies Mechanisms Development Allergy (MeDALL) consortium. Parental habits health outcomes (early transient, persistent, adolescent-onset rhinoconjunctivitis) were based...
Abstract Background/objectives Sleeping behavior and individual prospensity in sleep timing during a 24 h period, known as chronotypes, are underestimated factors, which may favor the development of obesity metabolic diseases. Furthermore, melatonin is to play an important role circadian rhythm, but was also suggested directly influence metabolism bodyweight regulation. Since disturbed shifted rhythms have been observed adolescents with obesity, this study aimed investigate potential...
Chronic neck pain is a highly prevalent condition. Learning relaxation technique recommended by numerous guidelines for chronic pain. Smartphone apps can provide exercises; however, their effectiveness, especially in self-care setting, unclear.The aim of this pragmatic randomized trial to evaluate whether app-based exercises, including audio-based autogenic training, mindfulness meditation, or guided imagery, are more effective reducing than usual care alone.Smartphone owners aged 18 65...
There is increasing interest in using endovascular methods instead of surgical reconstruction to treat popliteal artery aneurysms. Exclusive use the Viabahn stentgraft, a nitinol stent covered with expanded polytetrafluoroethylene, was assessed treatment patients who presented aneurysms absence acute limb ischemia. Technical success, endoleaks, graft patency, freedom from amputation, and aneurysm sac flow size changes were by duplex ultrasound. From June 2004 March 2006, 16 men (mean age, 76...
The allergy preventive effects of gut immune modulation by bacterial compounds are still not fully understood.We sought to evaluate the effect lysate applied orally from second until seventh months life on prevalence allergic diseases at school age.In a randomized, placebo-controlled trial, 606 newborns with least one parent received consisting heat-killed Gram-negative Escherichia coli Symbio and Gram-positive Enterococcus faecalis or placebo week 5 end month 7. A total 402 children were...
Abstract Background The aim of the trial was to investigate effect a hypnotherapeutic group program in healthy persons with increased levels perceived stress. Methods In randomized controlled multicenter participants self-assessed subjective stress level ≥ 40 mm on visual analogue scale (0–100 mm; VAS) for previous week and stable state health were either 5 weekly sessions 120-min duration reduction improved coping plus hypnosis audiorecords individual practice at home an educational booklet...
Nonspecific chronic neck pain (cNP) is common in adult violinists and violists often treated with osteopathic medicine (OM), although the effectiveness of this treatment has not been determined to date. This study aimed evaluate safety OM cNP.In a two-armed randomized controlled single-center open trial, violists, including music students, cNP (⩾12 weeks) were either five individualized sessions (OM group) or no intervention (control group, CG) outpatient clinic for integrative medicine,...
C-C-chemokine receptors (CCRs) are expressed on a variety of immune cells and play an important role in many processes, particularly leukocyte migration. Comprehensive preclinical research demonstrated CCR2/CCR5-dependent pathways as pivotal for the pathophysiology severe COVID-19. Here we report human data use chemokine receptor inhibitor patients with COVID-19.Interim results 2:1 randomised, placebo-controlled, investigator-initiated trial CCR2/CCR5-inhibitor Cenicriviroc (CVC) 150 mg BID...
The well-being and healthy development of children are at risk in families with severe psychosocial stress. In Germany, simple valid screening instruments lacking to identify need early support.We aimed examine the diagnostic accuracy a perinatal form high risk.For every mother giving birth Charité Berlin between January August 2013 short Babylotse-Plus 27 items was filled out by medical staff. Completing took about 5 min. After calculating sum score, values ≥3 were defined as "likely risk"....
Objectives: Data on cognitive testing in migrants Germany are scarce. We aimed to evaluate the Montreal Cognitive Assessment (MoCA) Turkish Berlin and its association with demographics health-related variables.Method: For this cross-sectional study, a random sample of persons names was drawn from registration-office. function assessed using MoCA; 0 = worst, 30 best total score. Multivariable linear regression models were calculated determine associated factors MoCA-score.Results: In our...
To determine the potential anti-inflammatory effect of a multimodal periodic fasting programme on surrogate parameters periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS).A total 47 were recruited and an integrative ward intensified two-week fasting, diet lifestyle programme. Patients periodontally examined at baseline (t1), after 2-week protocol (t2) and, subsequently, 4 months (t3). The following determined: screening index (PSI), bleeding probing...
Abstract Background Myopia is a growing healthcare concern worldwide. Increasing evidence suggests that sleep and circadian rhythms may be associated with myopia. Furthermore, the risk factors of myopia have not been studied in Estonian population to date. This study aimed evaluate chronotype, lifestyle factors, parental relation secondary school students. Methods Grade 10 students from three schools Tallinn, each distinct focuses: one science-oriented, arts-oriented, sports-oriented, were...
Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation Graves’ ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that may be related muscle development. Serum samples (n = 408) from young overweight subjects 143) were collected during a lifestyle intervention study. Anthropometric parameters, along with leptin, and concentrations, analyzed, categorized into positive or negative for IGF1R-aAb. Eleven out 143 (7.7%)...