A5045204938- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neuroendocrine Tumor Research Advances
- Organ Donation and Transplantation
- Cancer Research and Treatments
- Artificial Intelligence in Healthcare
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- Genetics, Bioinformatics, and Biomedical Research
- Neurological Complications and Syndromes
- Statistical Methods and Bayesian Inference
- Liver Diseases and Immunity
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2016-2025
München Klinik
2022-2024
Heidelberg University
2007-2016
Frauenklinik Heidelberg
2007-2008
Universitäts Frauenklinik
2008
Background: While 4 randomized controlled clinical trials confirmed the early benefits of hypothermic oxygenated machine perfusion (HOPE), high-level evidence regarding long-term outcomes is lacking. The aim this follow-up study from HOPE-ECD-DBD trial was to compare in patients who underwent liver transplantation using extended criteria donor allografts donation after brain death (ECD-DBD), either HOPE or static cold storage (SCS). Methods: Between September 2017 and 2020, recipients...
Abstract Background In the recent International Study Group of Pancreatic Surgery (ISGPS) consensus on extended pancreatectomy, several issues perioperative outcome and long-term survival remained unclear. Robust data outcomes are sparse. The present study aimed to assess pancreatectomy for borderline resectable locally advanced pancreatic cancer. Methods A consecutive series patients with primary adenocarcinoma undergoing pancreatectomies, as defined by new ISGPS consensus, were compared...
Despite strong evidence for improved preservation of donor livers by machine perfusion, longer post-transplant follow-up data are urgently needed in an unselected patient population. We aimed to assess long-term outcomes after transplantation hypothermic oxygenated perfusion (HOPE)-treated based on real-world (i.e., IDEAL-D stage 4). In this international, multicentre, observational cohort study, we collected from adult recipients HOPE-treated transplanted between January 2012 and December...
Hepatocellular Carcinoma (HCC) still is one of the most detrimental malignant diseases in world. As two curative surgical therapies exist, discussion whether to opt for liver resection (LR) or transplantation (LT) ongoing, especially as novel techniques improve outcome have emerged both. The aim study was investigate how utilization and respective modalities changed through time.
(1) Background: Post-reperfusion syndrome (PRS) and electrolyte shifts (ES) represent considerable challenges during liver transplantation (LT) being associated with significant morbidity. We aimed to investigate the impact of hypothermic oxygenated machine perfusion (HOPE) on PRS ES in LT. (2) Methods: In this retrospective study, we compared intraoperative parameters 100 LTs, 50 HOPE preconditioned grafts stored static cold storage (SCS). During reperfusion phase, prospectively registered...
A substantial number of viable donor livers are discarded due to the donor's underlying malignancy. Concurrently, patients with certain liver malignancies - such as unresectable colorectal cancer metastases (CRC-LM), intrahepatic or perihilar cholangiocarcinoma (iCCC/phCCC), hepatocellular carcinoma (HCC) responding immunotherapy often face poor survival outcomes and deemed ineligible for potentially curative transplantation. In this context, a rational risk-benefit analysis suggests that...
Background. Simultaneous pancreas-kidney transplantation (SPKT) is the therapy of choice for selected patients with complicated type 1 diabetes mellitus and end-stage renal disease. Pancreas rescue allocation was implemented in Eurotransplant algorithms to increase organ utilization, concurrently facilitating supposedly inferior quality organs. The aim this study examine whether outcomes SPKT after allocation, which can either be recipient-oriented extended or competitive were as good...
To date, little is known about the duration and effectiveness of immunity as well possible adverse late effects after an infection with SARS-CoV-2. Thus it unclear, when if liver transplantation can be safely offered to patients who suffered from COVID-19. Here, we report on a successful shortly convalescence COVID-19 subsequent partial seroreversion recurrence prolonged shedding viral RNA.
Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. The specific features of coronavirus disease 2019 (COVID-19) in immunosuppressed are largely unknown and therapeutic experience is lacking. Seven (two liver, three kidneys, one double lung, heart) admitted to the Ludwig-Maximilians-University Munich because COVID-19 tested positive SARS-CoV-2 were included. clinical course findings extracted from medical record....
Abstract Background Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC) is still associated with poor prognosis. The feasibility of potentially curative liver resection (LR) transplantation (LT) limited by the underlying disease a shortage organ donors. Especially after LR, high recurrence rates present problem circulating tumor cells are major cause extrahepatic recurrence. Tigecycline, commonly used glycylcycline...
The calcineurin inhibitor tacrolimus, which is available as an immediate- or extended-release formulation, the standard-of-care immunosuppression after kidney transplantation with low rejection rates, especially in first year transplantation. However, its highly variable metabolism rate, narrow therapeutic window, and nephrotoxic side effects require close drug monitoring individual dosing. Here, we describe application of tacrolimus (ER-Tac) twice daily beneficial a transplant recipient...
The "digital era" in the field of medicine is new "here and now". Artificial intelligence has entered many fields recently emerging organ transplantation. Solid organs remain a scarce resource. Being able to predict outcome after liver transplantation promises solve one long-standing problems within What perfect donor recipient match? Within this work we developed validated novel deep-learning-based donor-recipient allocation system for transplantation.In study used data collected from all...
Liver transplantation and liver resection are curative options for early hepatocellular carcinoma (HCC). The outcome is in part depended on the immunological response to malignancy. In this study, we aimed identify profiles of non-HCV/non-HBV HCC patients.Thirty-nine immune cell subsets were measured with multicolor flow cytometry. This immunophenotyping was performed peripheral blood (PB) tumor specimens 10 patients healthy donors. signatures highly differential leukocyte count (hDIF)...
Background. Whenever the kidney standard allocation (SA) algorithms according to Eurotransplant (ET) Kidney Allocation System or Senior Program fail, rescue (RA) is initiated. There are 2 procedurally different modes of RA: recipient oriented extended (REAL) and competitive (CRA). The objective this study was evaluate association patient survival graft failure with RA mode whether not it varied across ET countries. Methods. database retrospectively analyzed for donor clinical demographic...
: Surgeries represent a mainstay of medical care globally. Patterns complications are frequently recognized late and place considerable burden on health systems. The aim was to develop test the first deep learning-adjusted CUSUM program (DL-CUSUM) predict monitor in-hospital mortality in real time after liver transplantation.
The purpose of this study is to evaluate the technical and clinical outcome percutaneous transhepatic biliary drainage (PTBD) in patients with leakage. All who underwent ultrasound-assisted PTBD between January 2017 December 2021 due leakage nondilated systems were retrospectively evaluated for periprocedural characteristics, medical indications, success (successful placement catheter), (resolved leak without additional procedures), fluoroscopy time, procedure duration, outcomes. 74 a mean...
<b><i>Introduction:</i></b> Liver (hepatic) fibrosis (LF) is characterized by impaired function and regenerative capacity of the liver can lead to significantly increased morbidity mortality in context surgical resection (LR). For this reason, it crucial identify extent LF preoperatively. Interleukin-6 (IL-6) known play a key role pathogenesis LF, but its exact value as preoperative marker unknown. This study aimed investigate correlation between preoperatively...
With an incidence of 338,000 estimated new cases and 330,000 deaths, pancreatic cancer is the 7th most common cause death worldwide representing one deadly malignancies (1). Because locoregional growth pattern with infiltration visceral arteries that are adjacent to pancreas early systemic spread, palliative therapy indicated in almost 80% cases. Most importantly, complete tumour resection relevant predictor long-term survival cancer. Just recently, promising results ESPAC 4 trial applied...
Introduction The human circadian clocks’ central regulator is located in the suprachiasmatic nucleus hypothalamus regulating local clocks peripheral tissues. It influences rhythmic physiology such as detoxification, metabolism, hormonal secretion, and nutrient uptake. Impaired hepatic are associated with metabolic inflammatory liver diseases. In this study, we therefore aimed to investigate associations of phase transplant donation outcome patients after transplantation.
Introduction Since its introduction in 2002 the Model of End Stage Liver Disease (MELD)-score is used for liver allocation. As treatment options, donor age and patient characteristics change, MELD-score needs regular revision. In fact, infections were identified as cause consequence acute decompensation. While leading to transient peaks MELD-score, also represent a main reason changes waiting list status, thus hindering transplantation. Aim this study was investigate detail effect...