A5000905393- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Chronic Kidney Disease and Diabetes
- Long-Term Effects of COVID-19
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Ultrasound and Hyperthermia Applications
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Impact on Reproduction
- Cardiovascular Health and Disease Prevention
- Neurological Complications and Syndromes
- Hematopoietic Stem Cell Transplantation
- Central Venous Catheters and Hemodialysis
- Liver Disease and Transplantation
- Nitric Oxide and Endothelin Effects
- Cytomegalovirus and herpesvirus research
- Hemodynamic Monitoring and Therapy
- Ultrasound Imaging and Elastography
- Advanced Glycation End Products research
- Metabolism and Genetic Disorders
Ludwig-Maximilians-Universität München
2020-2024
LMU Klinikum
2020-2024
Klinikum rechts der Isar
2014-2023
Technical University of Munich
2014-2023
München Klinik
2021
Genomics England
2020
RELX Group (United States)
2020
Euroimmun Medizinische Labordiagnostika (Germany)
2019
Deutsches Herzzentrum München
2016
University of Tübingen
2012
Rationale : Patients with end-stage renal disease are characterized by increased cardiovascular and all-cause mortality because of advanced remodeling the macrovascular microvascular beds. Objective The aim this study was to determine whether retinal function can predict in patients disease. Methods Results In multicenter prospective observational ISAR (Risk Stratification End-Stage Renal Disease), data on dynamic vessel analysis were available a subcohort 214 dialysis (mean age, 62.6±15.0;...
Background and purpose: Beyond the medical history, clinical exam lab findings, non-invasive ultrasound parameters such as kidney size Doppler values (e.g. resistive index) are important tools assisting decision making in
The prevalence of cognitive impairment in hemodialysis patients is notably high. In previous studises performed the general population, has been associated with increased mortality.We evaluated relationship between global function tested by a short screening instrument and mortality patients.Cognitive testing was 242 maintenance under standardized conditions at baseline using Montreal Cognitive Assessment (MoCA).Cognitive defined as MoCA test score ≤24 points, published previously. All-cause...
Urinary neutrophil gelatinase-associated lipocalin (NGAL) has emerged an early marker protein, predicative of acute kidney injury (AKI) in various clinical settings. Here, we demonstrate urinary NGAL to allow for differential diagnosis AKI, accurately discriminating allograft rejection from other causes AKI renal recipients.Urinary was assessed spot urine 182 outpatient recipients on maintenance immunosuppression. Samples were blinded and concentrations determined by enzyme-linked...
A novel in-vitro test (T50-test) assesses ex-vivo serum calcification propensity which predicts mortality in HD patients. The association of longitudinal changes T50 with all-cause and cardiovascular has not been investigated. We assessed paired sera collected at baseline 24 months 188 prevalent European patients from the ISAR cohort, most whom were Caucasians. Patients followed for another 19 [interquartile range: 11-37] months. Serum exhibited a significant decline between (246 ± 64 to 190...
A novel in vitro test (T50 test) assesses ex vivo serum calcification propensity and predicts mortality chronic kidney disease haemodialysis (HD) patients. For the latter, a time-dependent decline of T50 was shown to relate mortality. Here we assessed whether 3-month switch acetate-free, citrate-acidified, standard bicarbonate HD (CiaHD) sustainably improves propensity.T50 values were paired midweek pre-dialysis sera collected before 3 months after CiaHD 78 prevalent European In all, 44 then...
Renal ischemia-reperfusion injury (IRI) leads to acute kidney or delayed allograft function, which predisposes fibrosis in the native transplant. Here we investigated role of signal transducer and activator transcription 1 (STAT1) inflammatory responses following renal IRI. Our study showed that a subsequent stimulation Janus-activated kinase 2/STAT1 Toll-like receptor 4 pathways led greater STAT1 activation followed by increased cytokine compared with single-pathway murine tubular cells....
Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS-CoV-2) infection. The specific features of coronavirus disease 2019 (COVID-19) in immunosuppressed are largely unknown and therapeutic experience is lacking. Seven (two liver, three kidneys, one double lung, heart) admitted to the Ludwig-Maximilians-University Munich because COVID-19 tested positive SARS-CoV-2 were included. clinical course findings extracted from medical record....
Mortality in hemodialysis patients still remains unacceptably high. Enhanced arterial stiffness is a known cardiovascular risk factor, and pulse wave velocity (PWV) has proven to be valid parameter quantify risk. Recent studies showed controversial results regarding the prognostic significance of PWV for mortality patients, which may due methodological issues, such as assessment office setting (Office-PWV).This study cohort contains from "Risk stratification end-stage renal disease - ISAR...
Abstract Data on risk factors predicting rapid progression to end-stage renal disease (ESRD) or short-term kidney function decline (i.e., within 1 year) in chronic (CKD) are rare but urgently needed plan treatment. This study describes the association and predictive value of urinary uromodulin (uUMOD) for CKD. We assessed uUMOD, demographic/treatment parameters, estimated glomerular filtration rate (eGFR), proteinuria 230 CKD patients stage I-V. ESRD 25% eGFR was documented at end follow-up...
The increasing organ shortage in kidney transplantation leads to the necessity use kidneys previously considered unsuitable for transplantation. Numerous studies illustrate need a better decision guidance rather than only classification into from standard or expanded criteria donors referred as SCD/ECD-classification. donor profile index (KDPI) exhibits score utilizing much higher number of characteristics. Moreover, graft biopsies provide an opportunity assess quality.In single center...
The calcineurin inhibitor tacrolimus, which is available as an immediate- or extended-release formulation, the standard-of-care immunosuppression after kidney transplantation with low rejection rates, especially in first year transplantation. However, its highly variable metabolism rate, narrow therapeutic window, and nephrotoxic side effects require close drug monitoring individual dosing. Here, we describe application of tacrolimus (ER-Tac) twice daily beneficial a transplant recipient...
The ISAR study is a prospective, longitudinal, observational cohort to improve the cardiovascular risk stratification in endstage renal disease (ESRD). major goal characterize phenotype of subjects, namely alterations micro- and macrocirculation determine autonomic function. We intend recruit 500 prevalent dialysis patients 17 centers Munich surrounding area. Baseline examinations include: (1) biochemistry, (2) 24-h Holter Electrocardiography (ECG) recordings, (3) ambulatory blood pressure...
Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging promote coronary artery disease (CAD). Recent animal studies give evidence that Toll-like receptor 4 (TLR4) modulate contribute to age-dependent SBP increase. However, there are no data about TLR4 increase in human.We therefor investigate human cohort 2679 patients CAD...
Abstract Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age‐matched general population. Impaired microcirculatory function is one assumed causes. Dynamic retinal vessel analysis a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that associated with altered microcirculation vessels. Methods 152 chronic hemodialysis underwent testing using Montreal...
Background. Preformed donor-specific HLA antibodies (DSA) are a well-known risk factor in kidney transplantation. There is still considerable debate, however, about the optimal stratification among patients with preformed DSA. Additionally, data on prognostic value of different crossmatch assays DSA-positive scarce. Methods. living transplant recipients were selected from multicenter study examining 4233 consecutive renal transplants. An additional 7 2 further centers included. Flow...
Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 are involved in development hypothesized obesity-associated hypertension and investigated single nucleotide polymorphism (SNP rs 498790). This SNP frequent, cardiovascular disease characterized by blunted response upon exposure to...
Abstract Background In hemodialysis patients, left ventricular hypertrophy (LVH) contributes to high cardiovascular mortality. We examined mortality prediction by the recently proposed Peguero-Lo Presti voltage since it identifies more patients with electrocardiographic (ECG) LVH than Cornell or Sokolow-Lyon voltages. Methods A total of 308 on underwent 24 h ECG recordings. parameters were measured before and after dialysis. The primary endpoint was recorded during a median 3-year follow up....