A5091621279- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Adolescent and Pediatric Healthcare
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- CAR-T cell therapy research
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Parasites and Host Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Clinical Nutrition and Gastroenterology
- Immune Cell Function and Interaction
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- IL-33, ST2, and ILC Pathways
The University of Texas Health Science Center at Houston
2013-2023
Memorial Hermann
2017-2023
Baylor College of Medicine
2019
Pediatrics and Genetics
2017
Hospital of the University of Pennsylvania
2014
University of Houston
2012
University of Alabama at Birmingham
1998-2011
Background: Patients infected with hepatitis C virus (HCV) frequently develop renal failure after liver transplantation. Objective: To describe histologic characteristics and concomitant clinical features in HCV-infected patients end-stage cirrhosis. Design: Case series. Setting: Single-center transplant program the United States. Patients: 30 who received transplants for HCV-induced Intervention: Kidney biopsy during engraftment. Measurements: Clinical data laboratory tests of function...
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper immune responses. Unexpectedly, we identified rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no were detectable healthy tissues before Studies with two genetic mouse models eosinophil deficiency and model antibody-mediated depletion revealed exacerbated injury ischemia reperfusion. Adoptive transfer bone marrow-derived normalized eosinophil-deficient mice reduced...
Hepatic ischemia and reperfusion (IR) injury contributes to the morbidity mortality associated with liver transplantation. microRNAs (miRNAs) constitute a family of noncoding RNAs that regulate gene expression at posttranslational level through repression specific target genes. Here, we hypothesized miRNAs could be targeted enhance hepatic tolerance. A miRNA screen in murine model IR pointed us toward liver-specific miR122. Subsequent studies mice hepatocyte-specific deletion miR122...
Abstract The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process tumorigenesis would aid in establishing targets for effective prevention therapy. Here, we interrogated differential molecular mechanisms dependent on cell origin subtype promote PDAC initiation established tumors. Transcriptomic analysis cell-of-origin–dependent epithelial gene signatures...
The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) is a psychometric instrument designed to assess patient risk transplant. We investigated the association between SIPAT scores and demographic data with psychosocial medical outcomes within diverse kidney/kidney-pancreas transplant population.The was administered all pretransplant candidates. A retrospective review of transplanted patients who had at least 6 months follow-up completed.The sample included 136 patients:...
Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility center.Patients were identified from referral list (from July 2012 to June 2017). Demographics, pretransplant laboratory, serological screenings retrospectively collected. For Strongyloides-seropositive (SSp) patients, data on travel history, symptoms,...
Surgical resection of primary or metastatic tumors the liver offers patients best long-term survival. Liver resections may not be appropriate in with bilobar metastases, dysfunction, severe comorbidities. Radiofrequency ablation (RFA) is a technique used to destroy unresectable hepatic through thermocoagulation. We retrospectively reviewed consecutive series undergoing RFA for local recurrence and overall Under an Institutional Review Board-approved protocol, all treated at University...
Left ventricular hypertrophy (LVH) occurs in 12% to 30% of patients with cirrhosis; however, its prognostic significance is not well studied. We assessed the association LVH survival undergoing a liver transplantation (LT) evaluation. performed multicenter cohort study an evaluation for LT. was defined transthoracic echocardiography. The outcome interest all-cause mortality. present 138 485 (28%). Patients were older, more likely be male and African American, have hypertension. Three hundred...
Patient and graft survival after liver transplantation are adversely affected by early posttransplant renal dysfunction. Therefore, our immunosuppressive strategies should be as "renal sparing" possible. This is the largest published series to date using daclizumab induction therapy in a renal-sparing regimen.This retrospective, nonrandomized study comparing 209 adult transplants with 115 no induction.Patient were similar, despite higher pretransplant acuity of illness older age group. Acute...
Updating live vaccines such as measles, mumps, rubella, and varicella (MMRV) is an important step in preparing patients for solid organ transplant (SOT) to prevent morbidity from these preventable diseases. However, data this approach are scarce. Thus, we aimed describe the seroprevalence of MMRV efficacy our center.Pre-SOT candidates >18 y age were retrospectively retrieved SOT database Memorial Hermann Hospital Texas Medical Center. serologies routinely screened at time pretransplant...
Hereditary tyrosinemia type 1 (HT-1) is a metabolic disorder caused by defect in tyrosine degradation.Without treatment, symptoms of hepatomegaly, renal tubular dysfunction, growth failure, neurologic crises resembling porphyrias, rickets and possible hepatocellular carcinoma can develop.The use 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione early diagnosis through newborn screening initiatives have resulted sharp decline morbidity mortality associated with this disease.We present...
The safety and efficacy of endoscopic retrograde cholangiopancreatography (ERCP) in the evaluation management biliary tract complications after orthotopic liver transplantation (OLT) have been previously demonstrated. However, role ERCP evaluating asymptomatic OLT patients with abnormal enzymes a normal tree remains poorly defined. We sought to assess utility this subset patients.A retrospective analysis of-asymptomatic evaluated by was undertaken. In addition ERCP, all these had diagnostic...
Wilson's disease (WD) is characterized by hepatic, neurological, and/or psychiatric disturbances. In some cases, liver transplantation indicated. Because psychologists and other health care workers play an increasing role in the evaluation of individuals presenting for transplant, understanding heterogeneous phenotype WD important mental professionals working medical settings. This article reviews two cases patients with (one probable, one confirmed) a biopsychosocial assessment approach...
The issue of containing cost has had a significant impact on organ transplantation. After our institution's 500th liver transplant, we critically examined the changing health care environment transplantation.We retrospectively analyzed 500 consecutive transplants done in period 1989 to 1998.Comparing first 100 last 100, patient demographics did not change significantly; however, mean waiting times increased significantly, from 30.4 days 146.7 days, and median hospital stay decreased 20.2...
A 67-year-old man presented for urgent liver transplantation (LT). Screening revealed the rare combination of antiRhesus (D) and antiKidd Jk(a) antibodies, requiring antigen-negative red blood cells (RBC) both phenotypes. This has not been reported during LT. Compatible RBCs were initially limited, continued communication between bank/blood supplier to obtain more, including frozen, units. Additional strategies included use cell salvage intentional management coagulopathy limit bleeding RBC...