A5084537553- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Estrogen and related hormone effects
- Adolescent and Pediatric Healthcare
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
- Pancreatitis Pathology and Treatment
- Retinoids in leukemia and cellular processes
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- Bipolar Disorder and Treatment
- Peptidase Inhibition and Analysis
- Fatty Acid Research and Health
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Tea Polyphenols and Effects
- Chronic Lymphocytic Leukemia Research
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Electroconvulsive Therapy Studies
The University of Texas MD Anderson Cancer Center
2013-2024
The University of Texas Health Science Center at Houston
2021
Dartmouth College
2016
National Cancer Institute
2012
Memorial Sloan Kettering Cancer Center
2012
University of California, San Diego
2012
Louisiana State University Health Sciences Center Shreveport
2012
Houston Methodist
2012
Methodist Hospital
2012
Methodist Hospital
2012
Article AbstractObjective: To assess the experience of selected individuals living with bipolar disorder and compare this that a similar group sampled in 1992. Method: In June 2000, 4192 self-administered questionnaires were sent to National Depressive Manic-Depressive Association chapters for distribution support participants diagnosed disorder. By July 31, first 600 completed surveys analyzed. Results: Over one third respondents sought professional help within 1 year onset symptoms....
Epidemiologic data support an inverse association between green tea intake and breast cancer risk, numerous experimental studies have shown the antitumor effects of its main component, epigallocatechin gallate (EGCG). We conducted a phase IB dose escalation trial in women with history stage I to III hormone receptor-negative oral extract, polyphenon E (Poly E) 400, 600, 800 twice daily or matching placebo for 6 months. The primary endpoint was determine maximum tolerated (MTD), defined as...
Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making ideal target cancer prevention. Our objective was to evaluate safety, assess activity and discover novel molecular pathways involved of naproxen as primary secondary chemoprevention patients LS.
Abstract The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process tumorigenesis would aid in establishing targets for effective prevention therapy. Here, we interrogated differential molecular mechanisms dependent on cell origin subtype promote PDAC initiation established tumors. Transcriptomic analysis cell-of-origin–dependent epithelial gene signatures...
Successful therapeutic cancer prevention requires definition of the minimal effective dose. Aromatase inhibitors decrease breast incidence in high-risk women, but use and compliance adjuvant settings are hampered by adverse events.
Abstract NeuVax is a vaccine comprised of the HER2-derived MHC class I peptide E75 (nelipepimut-S, NPS) combined with GM-CSF. We completed randomized trial preoperative vaccination versus GM-CSF alone in patients ductal carcinoma situ (DCIS). The primary objective was to evaluate for NPS-specific cytotoxic T lymphocyte (CTL) responses. Patients human leukocyte antigen (HLA)-A2-positive DCIS were enrolled and 2:1 received two inoculations prior surgery. number CTL measured pre-vaccination, at...
Abstract Obesity, a cause of subclinical inflammation, is risk factor for the development postmenopausal breast cancer and associated with poorer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment DHA would reduce expression proinflammatory genes aromatase, rate-limiting enzyme estrogen biosynthesis, in benign tissue overweight/obese women. A randomized, placebo-controlled, double-blind phase II study given 12...
Objective: Depressive disorders are common in asthma. Despite the high prevalence, antidepressant therapy asthma patients with depression remains under-investigated. The objective of this pilot study was to investigate use bupropion for and anxiety depressed patients. Method: We conducted a 12-week open-label 18 Participants were assessed Hamilton Rating Scale Depression (HAM-D-17), Anxiety (HAM-A), Inventory Symptomatology—Self-Report (IDS-SR), Asthma Control Questionnaire (ACQ) spirometry...
In a 3-arm presurgical trial, four-six weeks exemestane 25 mg three times/week (TIW) was non-inferior to mg/day (QD) in suppressing circulating estradiol postmenopausal women with ER-positive breast cancer. Since obesity may decrease efficacy, we analyzed changes sex steroids, adipokines, Ki-67, and drug levels relation obesity. Postmenopausal early-stage cancer were randomized either QD (n = 57), TIW or mg/week (QW, n 62) for 4-6 before surgery. Serum tissue pre- post-treatment biomarkers...
Immunoprevention is an emerging consideration for solid tumors, including pancreatic ductal adenocarcinoma (PDAC). We and others have shown that Kras mutations in genetic models of spontaneous intraepithelial neoplasia (PanIN), which a precursor to PDAC, results CD73 expression the neoplastic epithelium some populations infiltrating immune cells, macrophages CD8 T cells. ecto-enzyme converts extracellular adenosine monophosphate adenosine, critical inhibitory molecule PDAC. hypothesized...
Background Recent clinical trial data from Lynch Syndrome (LS) carriers demonstrated that naproxen administered for 6-months is a safe primary chemoprevention promotes activation of different resident immune cell types without increasing lymphoid cellularity. While intriguing, the precise enriched by remained unanswered. Here, we have utilized cutting-edge technology to elucidate activated in mucosal tissue LS patients. Methods Normal colorectal mucosa samples (pre- and post-treatment)...
Abstract Prevention of estrogen receptor (ER)-positive breast cancer is now possible using anti-estrogen drugs; however, this treatment ineffective against ER-negative cancers. In study, we hypothesized that inhibition mTOR will suppress the growth and triple-negative To test hypothesis, used five models: MMTV-erbB2, C3 (1)/SV40TAg, p53-null mammary gland-transplant, p53-mutant BRCA1co/co; MMTV-Cre+/+; p53+/– mouse models to determine whether inhibitor everolimus effective in preventing...
Abstract Agents that can reduce the incidence of hormone receptor negative breast cancer are currently lacking. Rexinoids such as bexarotene significantly reduced mammary tumor development in preclinical mouse models. Oral BRCA mutation carriers decreased cyclin D1 cells, suggesting biological activity on tissue. This study evaluated topical 1% gel applied to one unaffected women at high risk for 4 weeks assess safety and toxicity. Secondary objectives included assessment concentrations...
Abstract Female carriers of pathogenic/likely pathogenic (P/LP) BRCA1/2 variants are at increased risk developing breast and ovarian cancer. Currently, the only effective strategy for cancer reduction is risk-reducing bilateral salpingo-oophorectomy (RR-BSO), which carries adverse effects related to early menopause. There ongoing investigation inhibition RANK ligand (RANKL) with denosumab as a means chemoprevention in BRCA1 P/LP variants. Through NCI Division Cancer Prevention (DCP) Early...
Abstract Lung cancer screening by helical low-dose computed tomography detects nonsolid nodules that may be lung adenocarcinoma precursors. Aspirin’s anti-inflammatory properties make it an attractive target for prevention of multiple cancers, including cancer. Therefore, we conducted a phase IIb trial (NCT02169271) to study the efficacy aspirin reduce size subsolid (SSNs). A total 98 current or former smokers (67.3% current) undergoing annual with persistent SSNs were randomly assigned...
Abstract We evaluated the cancer preventive efficacy of TAK-242, an inhibitor Toll-like receptor 4 (TLR4), in a mouse model hepatocellular carcinoma (HCC) occurring context nonalcoholic steatohepatitis (NASH). also assessed cellular events associated with treatment efficacy. tested oral administration at clinically relevant but toxicity-reducing doses and scheduling, mice hepatocyte-specific deletion Pten (HepPten−). The optimal dose gavage formulation TAK-242 were determined to be 30 mg/kg...
Abstract Exemestane is an effective drug to reduce breast cancer risk reaching overall 65% reduction in the placebo–controlled phase III MAP.3 trial. To improve its acceptability primary prevention programs, we are seeking minimal dose. In a 3-arm presurgical trial of 4-6 weeks before surgery 180 postmenopausal women with ER-positive cancer, investigated activity alternative exemestane schedules: 25 mg per day (QD), three times/week (TIW) or week (QW) and showed that adherent participants...